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Ryan A. Heiser
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Journal Articles

PF-08046032: A Novel, Investigational CD25-Directed Antibody–Drug Conjugate Optimized for Selective Depletion of Regulatory T Cells in Advanced Malignant Tumors

Available to Purchase
Sherif Abdelhamed, Xinqun Zhang, Weiping Zeng, Bryan Grogan, Luke Schilperoort, Reice James, Kelli C. Burley, Samantha M. Sarrett, Lauren Bou, Paromita Raha, Devra J. Olson, Heather L. Sigurjonsson, Melissa M.C. Dominguez, Tyler Nicholas, Haley D. Neff-LaFord, James Fishburn, Andrea R. Lim, Daniel Diolaiti, Priyanka Gupta, Cristina L. Abrahams, Christopher M. Carosino, Ryan A. Heiser, Shyra J. Gardai, Matthew R. Levengood
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2025) 24 (7): 963–975.
https://doi.org/10.1158/1535-7163.MCT-25-0101
Published: 02 July 2025
View articletitled, PF-08046032: A Novel, Investigational CD25-Directed Antibody–Drug Conjugate Optimized for Selective Depletion of Regulatory T Cells in Advanced Malignant Tumors
Open the PDF for PF-08046032: A Novel, Investigational CD25-Directed Antibody–Drug Conjugate Optimized for Selective Depletion of Regulatory T Cells in Advanced Malignant Tumors in another window
Includes: Supplementary data
Journal Articles

Brentuximab Vedotin–Driven Microtubule Disruption Results in Endoplasmic Reticulum Stress Leading to Immunogenic Cell Death and Antitumor Immunity

Open Access
Ryan A. Heiser, Anthony T. Cao, Weiping Zeng, Michelle Ulrich, Patrick Younan, Martha E. Anderson, Esther S. Trueblood, Mechthild Jonas, Robert Thurman, Che-Leung Law, Shyra J. Gardai
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2024) 23 (1): 68–83.
https://doi.org/10.1158/1535-7163.MCT-23-0118
Published: 03 January 2024
View articletitled, Brentuximab Vedotin–Driven Microtubule Disruption Results in Endoplasmic Reticulum Stress Leading to Immunogenic Cell Death and Antitumor Immunity
Open the PDF for Brentuximab Vedotin–Driven Microtubule Disruption Results in Endoplasmic Reticulum Stress Leading to Immunogenic Cell Death and Antitumor Immunity in another window
Includes: Supplementary data