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Russell Dushin
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Journal Articles

Caveolae-Mediated Endocytosis as a Novel Mechanism of Resistance to Trastuzumab Emtansine (T-DM1)

Matthew Sung, Xingzhi Tan, Bingwen Lu, Jonathan Golas, Christine Hosselet, Fang Wang, Laurie Tylaska, Lindsay King, Dahui Zhou, Russell Dushin, Jeremy S. Myers, Edward Rosfjord, Judy Lucas, Hans-Peter Gerber, Frank Loganzo
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2018) 17 (1): 243–253.
https://doi.org/10.1158/1535-7163.MCT-17-0403
Published: 01 January 2018
View articletitled, Caveolae-Mediated Endocytosis as a Novel Mechanism of Resistance to Trastuzumab Emtansine (T-DM1)
Open the PDF for Caveolae-Mediated Endocytosis as a Novel Mechanism of Resistance to Trastuzumab Emtansine (T-DM1) in another window
Includes: Supplementary data
Journal Articles

RN927C, a Site-Specific Trop-2 Antibody–Drug Conjugate (ADC) with Enhanced Stability, Is Highly Efficacious in Preclinical Solid Tumor Models

Pavel Strop, Thomas-Toan Tran, Magdalena Dorywalska, Kathy Delaria, Russell Dushin, Oi Kwan Wong, Wei-Hsien Ho, Dahui Zhou, Aidong Wu, Eugenia Kraynov, Laura Aschenbrenner, Bora Han, Christopher J. O'Donnell, Jaume Pons, Arvind Rajpal, Dave L. Shelton, Shu-Hui Liu
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2016) 15 (11): 2698–2708.
https://doi.org/10.1158/1535-7163.MCT-16-0431
Published: 01 November 2016
View articletitled, RN927C, a Site-Specific Trop-2 Antibody–Drug Conjugate (ADC) with Enhanced Stability, Is Highly Efficacious in Preclinical Solid Tumor Models
Open the PDF for RN927C, a Site-Specific Trop-2 Antibody–Drug Conjugate (ADC) with Enhanced Stability, Is Highly Efficacious in Preclinical Solid Tumor Models in another window
Includes: Supplementary data
Journal Articles

Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design

Magdalena Dorywalska, Russell Dushin, Ludivine Moine, Santiago E. Farias, Dahui Zhou, Thayalan Navaratnam, Victor Lui, Adela Hasa-Moreno, Meritxell Galindo Casas, Thomas-Toan Tran, Kathy Delaria, Shu-Hui Liu, Davide Foletti, Christopher J. O'Donnell, Jaume Pons, David L. Shelton, Arvind Rajpal, Pavel Strop
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (5): 958–970.
https://doi.org/10.1158/1535-7163.MCT-15-1004
Published: 05 May 2016
View articletitled, Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design
Open the PDF for Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design in another window
Includes: Supplementary data
Journal Articles

Long-term Tumor Regression Induced by an Antibody–Drug Conjugate That Targets 5T4, an Oncofetal Antigen Expressed on Tumor-Initiating Cells

Puja Sapra, Marc Damelin, John DiJoseph, Kimberly Marquette, Kenneth G. Geles, Jonathon Golas, Maureen Dougher, Bitha Narayanan, Andreas Giannakou, Kiran Khandke, Russell Dushin, Elana Ernstoff, Judy Lucas, Mauricio Leal, George Hu, Christopher J. O'Donnell, Lioudmila Tchistiakova, Robert T. Abraham, Hans-Peter Gerber
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (1): 38–47.
https://doi.org/10.1158/1535-7163.MCT-12-0603
Published: 13 January 2013
View articletitled, Long-term Tumor Regression Induced by an Antibody–Drug Conjugate That Targets 5T4, an Oncofetal Antigen Expressed on Tumor-Initiating Cells
Open the PDF for Long-term Tumor Regression Induced by an Antibody–Drug Conjugate That Targets 5T4, an Oncofetal Antigen Expressed on Tumor-Initiating Cells in another window
Includes: Supplementary data
Journal Articles

Abstract A215: Antitumor activity of an antibody-drug conjugate targeting 5T4, a putative tumor-initiating cell antigen.

John DiJoseph, Maureen Dougher, Bitha Narayanan, Kiran Khandke, Kimberly Marquette, Russell Dushin, Marc Damelin, Judy Lucas, Mauricio Leal, George Hu, Jon Golas, Andreas Maderna, Frank Loganzo, Lioudmila Tchistiakova, Christopher O'Donnell, Robert Abraham, HansPeter Gerber, Puja Sapra
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): A215.
https://doi.org/10.1158/1535-7163.TARG-11-A215
Published: 12 November 2011
View articletitled, Abstract A215: Antitumor activity of an antibody-drug conjugate targeting 5T4, a putative tumor-initiating cell antigen.