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Journal Articles

Colchicine-Binding Site Agent CH-2-77 as a Potent Tubulin Inhibitor Suppressing Triple-Negative Breast Cancer

Shanshan Deng, Raisa I. Krutilina, Kelli L. Hartman, Hao Chen, Deanna N. Parke, Rui Wang, Foyez Mahmud, Dejian Ma, Pradeep B. Lukka, Bernd Meibohm, Tiffany N. Seagroves, Duane D. Miller, Wei Li
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (7): 1103–1114.
https://doi.org/10.1158/1535-7163.MCT-21-0899
Published: 05 July 2022
View article titled, Colchicine-Binding Site Agent CH-2-77 as a Potent Tubulin Inhibitor Suppressing Triple-Negative Breast Cancer
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Includes: Supplementary data
Journal Articles

Abstract P142: Preclinical characterization of LOX-22783, a highly potent, mutant-selective and brain-penetrant allosteric PI3Kα H1047R inhibitor

Anke Klippel, Rui Wang, Loredana Puca, Andrew Lee Faber, Weihua Shen, Shripad V. Bhagwat, Kannan Karukurichi, Feiyu Fred Zhang, Carmen Perez, Ramon Rama, Ana Ramos, Yi Zheng, Zahid Bonday, James Thomas, Harold B. Brooks, Lisa J. Kindler, Sarah M. Bogner, Parisa Zolfaghari, Mark Hicks II, Sophie Callies, Brian Mattioni, Laurie LeBrun, Jim Durbin, Erin Anderson, Chris Mayne, Edward Kesicki, Gabrielle Kolakowski, Steven W. Andrews, Barbara J. Brandhuber
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P142.
https://doi.org/10.1158/1535-7163.TARG-21-P142
Published: 01 December 2021
View article titled, Abstract P142: Preclinical characterization of LOX-22783, a highly potent, mutant-selective and brain-penetrant allosteric PI3Kα H1047R inhibitor
Journal Articles

Antihistamine Drug Ebastine Inhibits Cancer Growth by Targeting Polycomb Group Protein EZH2

Qiaqia Li, Kilia Y. Liu, Qipeng Liu, Guangyu Wang, Weihua Jiang, Qingshu Meng, Yang Yi, Yongyong Yang, Rui Wang, Sen Zhu, Chao Li, Longxiang Wu, Dongyu Zhao, Lin Yan, Lili Zhang, Jung-Sun Kim, Xiongbing Zu, Anthony J. Kozielski, Wei Qian, Jenny C. Chang, Akash Patnaik, Kaifu Chen, Qi Cao
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2020) 19 (10): 2023–2033.
https://doi.org/10.1158/1535-7163.MCT-20-0250
Published: 02 October 2020
View article titled, Antihistamine Drug Ebastine Inhibits Cancer Growth by Targeting Polycomb Group Protein EZH2
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Includes: Supplementary data
Journal Articles

Targeting Lineage-specific MITF Pathway in Human Melanoma Cell Lines by A-485, the Selective Small-molecule Inhibitor of p300/CBP

Rui Wang, Yupeng He, Valerie Robinson, Ziping Yang, Paul Hessler, Loren M. Lasko, Xin Lu, Anahita Bhathena, Albert Lai, Tamar Uziel, Lloyd T. Lam
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (12): 2543–2550.
https://doi.org/10.1158/1535-7163.MCT-18-0511
Published: 03 December 2018
View article titled, Targeting Lineage-specific MITF Pathway in Human Melanoma Cell Lines by A-485, the Selective Small-molecule Inhibitor of p300/CBP
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Includes: Supplementary data
Journal Articles

Arsenic Trioxide and Sorafenib Induce Synthetic Lethality of FLT3-ITD Acute Myeloid Leukemia Cells

Rui Wang, Ying Li, Ping Gong, Janice Gabrilove, Samuel Waxman, Yongkui Jing
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (9): 1871–1880.
https://doi.org/10.1158/1535-7163.MCT-17-0298
Published: 04 September 2018
View article titled, Arsenic Trioxide and Sorafenib Induce Synthetic Lethality of FLT3-ITD Acute Myeloid Leukemia Cells
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Includes: Supplementary data
Journal Articles

Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide–Hoechst Conjugate Suppresses Tumor Growth In Vivo

Ke Liu, Lijing Fang, Haiyan Sun, Zhengyin Pan, Jianchao Zhang, Juntao Chen, Ximing Shao, Wei Wang, Yuanyan Tan, Zhihao Ding, Lijiao Ao, Chunlei Wu, Xiaoqi Liu, Huashun Li, Rui Wang, Wu Su, Hongchang Li
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (5): 988–1002.
https://doi.org/10.1158/1535-7163.MCT-17-0747
Published: 30 April 2018
View article titled, Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide–Hoechst Conjugate Suppresses Tumor Growth <em>In Vivo</em>
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Includes: Multimedia, Supplementary data
Journal Articles

Abstract C38: Novel allosteric IDH1 mutant Inhibitors for differentiation therapy of acute myeloid leukemia

Ujunwa C. Okoye-Okafor, Boris Bartholdy, Jessy Cartier, Enoch Gao, Beth Pietrak, Alan R. Rendina, Cynthia Rominger, Chad Quinn, Angela Smallwood, Ken Wiggall, Alexander Reif, Stan Schmidt, Hongwei Qi, Huizhen Zhao, Gerard Joberty, Maria Faelth-Savitski, Marcus Bantscheff, Gerard Drewes, Chaya Duraiswami, Pat Brady, Swathi-Rao Narayanagari, Ileana Antony-Debre, Kelly Mitchell, Heng Rui Wang, Yun-Ruei Kao, Maximilian Christopeit, Luis Carvajal, Laura Barreyro, Elisabeth Paietta, Britta Will, Nestor Concha, Nicholas D. Adams, Benjamin Schwartz, Michael T. McCabe, Jaroslav Maciejewski, Amit Verma, Ulrich Steidl
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): C38.
https://doi.org/10.1158/1535-7163.TARG-15-C38
Published: 01 December 2015
View article titled, Abstract C38: Novel allosteric IDH1 mutant Inhibitors for differentiation therapy of acute myeloid leukemia
Journal Articles

Ethacrynic Acid Oxadiazole Analogs Induce Apoptosis in Malignant Hematologic Cells through Downregulation of Mcl-1 and c-FLIP, Which Was Attenuated by GSTP1-1

Guyue Liu, Rui Wang, Yuetong Wang, Pengzhan Li, Guisen Zhao, Linxiang Zhao, Yongkui Jing
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (9): 1837–1847.
https://doi.org/10.1158/1535-7163.MCT-12-1224
Published: 05 September 2013
View article titled, Ethacrynic Acid Oxadiazole Analogs Induce Apoptosis in Malignant Hematologic Cells through Downregulation of Mcl-1 and c-FLIP, Which Was Attenuated by GSTP1-1
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Journal Articles

The Potential Role of miR-451 in Cancer Diagnosis, Prognosis, and Therapy

Xuan Pan, Rui Wang, Zhao-Xia Wang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (7): 1153–1162.
https://doi.org/10.1158/1535-7163.MCT-12-0802
Published: 07 July 2013
View article titled, The Potential Role of miR-451 in Cancer Diagnosis, Prognosis, and Therapy
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