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Ricky W. Johnstone
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Journal Articles

Abstract LB-C02: In vitro on-target and selectivity profiling of small-molecule inhibitors of the Myc/Max heterodimeric complex

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SANG-KYU KIM, RICHARD C FOITZIK, SONGHUI LI, ANDREW VINSON, ALEX SHMAYLOV, KAREN JARVIS, SUSAN JAMES, SCOTT R WALKER, MARK YORK, BENJAMIN CAO, SUSAN K NILSSON, RICKY W JOHNSTONE
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): LB-C02.
https://doi.org/10.1158/1535-7163.TARG-19-LB-C02
Published: 01 December 2019
View articletitled, Abstract LB-C02: In vitro on-target and selectivity profiling of small-molecule inhibitors of the Myc/Max heterodimeric complex
Journal Articles

BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members

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Simon J. Hogg, Andrea Newbold, Stephin J. Vervoort, Leonie A. Cluse, Benjamin P. Martin, Gareth P. Gregory, Marcus Lefebure, Eva Vidacs, Richard W. Tothill, James E. Bradner, Jake Shortt, Ricky W. Johnstone
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (9): 2030–2041.
https://doi.org/10.1158/1535-7163.MCT-15-0924
Published: 01 September 2016
View articletitled, BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members
Open the PDF for BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members in another window
Includes: Supplementary data
Journal Articles

Molecular and Biologic Analysis of Histone Deacetylase Inhibitors with Diverse Specificities

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Andrea Newbold, Geoffrey M. Matthews, Michael Bots, Leonie A. Cluse, Christopher J.P. Clarke, Kellie-Marie Banks, Carleen Cullinane, Jessica E. Bolden, Ailsa J. Christiansen, Ross A. Dickins, Claudia Miccolo, Susanna Chiocca, Astrid M. Kral, Nicole D. Ozerova, Thomas A. Miller, Joey L. Methot, Victoria M. Richon, J. Paul Secrist, Saverio Minucci, Ricky W. Johnstone
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (12): 2709–2721.
https://doi.org/10.1158/1535-7163.MCT-13-0626
Published: 05 December 2013
View articletitled, Molecular and Biologic Analysis of Histone Deacetylase Inhibitors with Diverse Specificities
Open the PDF for Molecular and Biologic Analysis of Histone Deacetylase Inhibitors with Diverse Specificities in another window
Includes: Supplementary data
Journal Articles

Differential Induction of Apoptosis and Senescence by the DNA Methyltransferase Inhibitors 5-Azacytidine and 5-Aza-2′-Deoxycytidine in Solid Tumor Cells

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Sascha Venturelli, Alexander Berger, Timo Weiland, Frank Essmann, Michaela Waibel, Tina Nuebling, Sabine Häcker, Martin Schenk, Klaus Schulze-Osthoff, Helmut R. Salih, Simone Fulda, Bence Sipos, Ricky W. Johnstone, Ulrich M. Lauer, Michael Bitzer
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (10): 2226–2236.
https://doi.org/10.1158/1535-7163.MCT-13-0137
Published: 07 October 2013
View articletitled, Differential Induction of Apoptosis and Senescence by the DNA Methyltransferase Inhibitors 5-Azacytidine and 5-Aza-2′-Deoxycytidine in Solid Tumor Cells
Open the PDF for Differential Induction of Apoptosis and Senescence by the DNA Methyltransferase Inhibitors 5-Azacytidine and 5-Aza-2′-Deoxycytidine in Solid Tumor Cells in another window
Includes: Supplementary data
Journal Articles

In Vivo Activity of Combined PI3K/mTOR and MEK Inhibition in a KrasG12D;Pten Deletion Mouse Model of Ovarian Cancer

Free
Kathryn M. Kinross, Daniel V. Brown, Margarete Kleinschmidt, Susan Jackson, James Christensen, Carleen Cullinane, Rodney J. Hicks, Ricky W. Johnstone, Grant A. McArthur
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (8): 1440–1449.
https://doi.org/10.1158/1535-7163.MCT-11-0240
Published: 08 August 2011
View articletitled, In Vivo Activity of Combined PI3K/mTOR and MEK Inhibition in a KrasG12D;Pten Deletion Mouse Model of Ovarian Cancer
Open the PDF for In Vivo Activity of Combined PI3K/mTOR and MEK Inhibition in a KrasG12D;Pten Deletion Mouse Model of Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract B176: Synergistic induction of apoptosis by the histone‐deacetylase inhibitor, Panobinostat, combined with ABT‐737 or rhTRAIL, in multiple myeloma

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Geoffrey M. Matthews, Jake Shortt, Kellie M. Banks, Kym Stanley, David Faulkner, Leif Bergsagel, Marta Chesi, Peter Atadja, Ricky W. Johnstone
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): B176.
https://doi.org/10.1158/1535-7163.TARG-09-B176
Published: 10 December 2009
View articletitled, Abstract B176: Synergistic induction of apoptosis by the histone‐deacetylase inhibitor, Panobinostat, combined with ABT‐737 or rhTRAIL, in multiple myeloma
Journal Articles

Epigenetics in cancer: Targeting chromatin modifications

Free
Leigh Ellis, Peter W. Atadja, Ricky W. Johnstone
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (6): 1409–1420.
https://doi.org/10.1158/1535-7163.MCT-08-0860
Published: 10 June 2009
View articletitled, Epigenetics in cancer: Targeting chromatin modifications
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Journal Articles

Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin

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Andrea Newbold, Ralph K. Lindemann, Leonie A. Cluse, Kate F. Whitecross, Anthony E. Dear, Ricky W. Johnstone
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (5): 1066–1079.
https://doi.org/10.1158/1535-7163.MCT-07-2256
Published: 15 May 2008
View articletitled, Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin
Open the PDF for Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin in another window
Includes: Supplementary data