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Richard Wooster
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Journal Articles

Novel Miniaturized Drug Conjugate Leverages HSP90-driven Tumor Accumulation to Overcome PI3K Inhibitor Delivery Challenges to Solid Tumors

Samantha Perino, Benoit Moreau, Jessica Freda, Amanda Cirello, Brian H. White, James M. Quinn, Kristina Kriksciukaite, Ashwajith Someshwar, Janel Romagnoli, Megan Robinson, Sara Movassaghian, Tyler Cipriani, Richard Wooster, Mark T. Bilodeau, Kerry A. Whalen
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2020) 19 (8): 1613–1622.
https://doi.org/10.1158/1535-7163.MCT-19-0964
Published: 04 August 2020
View article titled, Novel Miniaturized Drug Conjugate Leverages HSP90-driven Tumor Accumulation to Overcome PI3K Inhibitor Delivery Challenges to Solid Tumors
Open the PDF for Novel Miniaturized Drug Conjugate Leverages HSP90-driven Tumor Accumulation to Overcome PI3K Inhibitor Delivery Challenges to Solid Tumors in another window
Includes: Supplementary data
Journal Articles

Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer

Kerry A. Whalen, Brian H. White, James M. Quinn, Kristina Kriksciukaite, Rossitza Alargova, Tsun P. Au Yeung, Patrick Bazinet, Adam Brockman, Michelle M. DuPont, Haley Oller, James Gifford, Charles-Andre Lemelin, Patrick Lim Soo, Samantha Perino, Benoît Moreau, Gitanjali Sharma, Rajesh Shinde, Beata Sweryda-Krawiec, Mark T. Bilodeau, Richard Wooster
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2019) 18 (11): 1926–1936.
https://doi.org/10.1158/1535-7163.MCT-19-0022
Published: 01 November 2019
View article titled, Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer
Open the PDF for Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Comprehensive Predictive Biomarker Analysis for MEK Inhibitor GSK1120212

Junping Jing, Joel Greshock, Joanna Dawn Holbrook, Aidan Gilmartin, Xiping Zhang, Elizabeth McNeil, Theresa Conway, Christopher Moy, Sylvie Laquerre, Kurt Bachman, Richard Wooster, Yan Degenhardt
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (3): 720–729.
https://doi.org/10.1158/1535-7163.MCT-11-0505
Published: 06 March 2012
View article titled, Comprehensive Predictive Biomarker Analysis for MEK Inhibitor GSK1120212
Open the PDF for Comprehensive Predictive Biomarker Analysis for MEK Inhibitor GSK1120212 in another window
Includes: Supplementary data
Journal Articles

Sensitivity of Cancer Cells to Plk1 Inhibitor GSK461364A Is Associated with Loss of p53 Function and Chromosome Instability

Yan Degenhardt, Joel Greshock, Sylvie Laquerre, Aidan G. Gilmartin, Junping Jing, Mark Richter, Xiping Zhang, Maureen Bleam, Wendy Halsey, Ashley Hughes, Christopher Moy, Nancy Liu-Sullivan, Scott Powers, Kurtis Bachman, Jeffrey Jackson, Barbara Weber, Richard Wooster
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (7): 2079–2089.
https://doi.org/10.1158/1535-7163.MCT-10-0095
Published: 07 July 2010
View article titled, Sensitivity of Cancer Cells to Plk1 Inhibitor GSK461364A Is Associated with Loss of p53 Function and Chromosome Instability
Open the PDF for Sensitivity of Cancer Cells to Plk1 Inhibitor GSK461364A Is Associated with Loss of p53 Function and Chromosome Instability in another window
Includes: Supplementary data
Journal Articles

Abstract A179: Synergistic interactions of Lapatinib and an AKT inhibitor in HER2 positive breast cancer cell lines depends on PI3K pathway status

James Korkola, Nora Bayani, Brian Cooper, Wen‐Lin Kuo, Jessica Billig, Saffiyah Ziyad, Heidi Feiler, Paul Spellman, Richard Wooster, Joe W. Gray
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): A179.
https://doi.org/10.1158/1535-7163.TARG-09-A179
Published: 10 December 2009
View article titled, Abstract A179: Synergistic interactions of Lapatinib and an AKT inhibitor in HER2 positive breast cancer cell lines depends on PI3K pathway status
Journal Articles

Abstract B173: Synergistic interaction between CENP‐E inhibitor GSK923295 and MEK inhibitor GSK1120212

Yan Y. Degenhardt, Xiping Zhang, Christopher Moy, Theresa Conway, Liz Mcneil, Junping Jing, Joel Greshock, Ronald Wegrzyn, Holy Yin, Spyro Mousses, Richard Wooster, Kurtis Bachman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): B173.
https://doi.org/10.1158/1535-7163.TARG-09-B173
Published: 10 December 2009
View article titled, Abstract B173: Synergistic interaction between CENP‐E inhibitor GSK923295 and MEK inhibitor GSK1120212
Journal Articles

Abstract B140: In vitro sensitivity profiling identifies selectively responsive tumor types and molecular subtypes to the PI3K inhibitor GSK2126458

Joel Greshock, Mary Ann Hardwicke, Theresa Conway, Yan Degenhardt, Leanne Cartee, Christopher Moy, Joanne Lager, Richard Wooster, Kurtis Bachman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): B140.
https://doi.org/10.1158/1535-7163.TARG-09-B140
Published: 10 December 2009
View article titled, Abstract B140: <em>In vitro</em> sensitivity profiling identifies selectively responsive tumor types and molecular subtypes to the PI3K inhibitor GSK2126458
Journal Articles

Abstract PR-10: RNAi‐directed identification of chemosensitizers of GSK923295 response

Holly Yin, Jeff Kiefer, Donald Chow, Quick Q. Que, Erica Dastrup, Barbara Weber, Richard Wooster, Spyro Mousses
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): PR-10.
https://doi.org/10.1158/1535-7163.TARG-09-PR-10
Published: 10 December 2009
View article titled, Abstract PR-10: RNAi‐directed identification of chemosensitizers of GSK923295 response
Journal Articles

Genome-wide DNA copy number predictors of lapatinib sensitivity in tumor-derived cell lines

Joel Greshock, Jie Cheng, David Rusnak, Anne Marie Martin, Richard Wooster, Tona Gilmer, Kwan Lee, Barbara L. Weber, Tal Zaks
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (4): 935–943.
https://doi.org/10.1158/1535-7163.MCT-07-2072
Published: 15 April 2008
View article titled, Genome-wide DNA copy number predictors of lapatinib sensitivity in tumor-derived cell lines
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Includes: Supplementary data
Journal Articles

Characterizing response to lapatinib (GW572016) in non-Her2 amplified tumor-derived cell lines

Joel greshock, William Cornwell, Yan Degenhardt, Kurtis Bachman, Christopher Moy, David Rusnak, Anne-Marie Martin, Tona Gilmer, Jie Cheng, Kwan Lee, Tal Zaks, Barbara Weber, Richard Wooster
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): C142.
Published: 01 November 2007
View article titled, Characterizing response to <em>lapatinib</em> (GW572016) in non-Her2 amplified tumor-derived cell lines
Journal Articles

Association of mutations in the TP53 gene and chromosome instability with sensitivity to the PLK1 inhibitor GSK461364

Richard Wooster, Yan Degenhardt, Joel Greshock, Sylvie Laquerre, Aidan Gilmartin, Kurt Auger, Junping Jing, Ganesh Sathe, Barbara Weber, Jeff Jackson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): C130.
Published: 01 November 2007
View article titled, Association of mutations in the TP53 gene and chromosome instability with sensitivity to the PLK1 inhibitor GSK461364
Journal Articles

Biomarkers that predict cancer cell line response to the AKT inhibitor GSK690693

Richard Wooster, Kumar Rakesh, Kurtis Bachman, Joel Greshock, Yan Degenhardt, Kurt Auger, Ganesh Sathe, Dilip Rajagopalan, Barbara Weber
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): C129.
Published: 01 November 2007
View article titled, Biomarkers that predict cancer cell line response to the AKT inhibitor GSK690693
Journal Articles

Mutation analysis of 24 known cancer genes in the NCI-60 cell line set

Ogechi N. Ikediobi, Helen Davies, Graham Bignell, Sarah Edkins, Claire Stevens, Sarah O'Meara, Thomas Santarius, Tim Avis, Syd Barthorpe, Lisa Brackenbury, Gemma Buck, Adam Butler, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Kristian Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jonathan Hinton, Chris Hunter, Andy Jenkinson, David Jones, Vivienne Kosmidou, Richard Lugg, Andrew Menzies, Tatiana Mironenko, Adrian Parker, Janet Perry, Keiran Raine, David Richardson, Rebecca Shepherd, Alex Small, Raffaella Smith, Helen Solomon, Philip Stephens, Jon Teague, Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, William Reinhold, John N. Weinstein, Michael R. Stratton, P. Andrew Futreal, Richard Wooster
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2006) 5 (11): 2606–2612.
https://doi.org/10.1158/1535-7163.MCT-06-0433
Published: 22 November 2006
View article titled, Mutation analysis of 24 known cancer genes in the NCI-60 cell line set
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Includes: Supplementary data