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René Bernards
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Journal Articles

NOTCH Signaling Limits the Response of Low-Grade Serous Ovarian Cancers to MEK Inhibition

Marta Llaurado Fernandez, E. Marielle Hijmans, Annemiek M.C. Gennissen, Nelson K.Y. Wong, Shang Li, G. Bea A. Wisman, Aleksandra Hamilton, Joshua Hoenisch, Amy Dawson, Cheng-Han Lee, Madison Bittner, Hannah Kim, Gabriel E. DiMattia, Christianne A.R. Lok, Cor Lieftink, Roderick L. Beijersbergen, Steven de Jong, Mark S. Carey, René Bernards, Katrien Berns
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (12): 1862–1874.
https://doi.org/10.1158/1535-7163.MCT-22-0004
Published: 02 December 2022
View article titled, NOTCH Signaling Limits the Response of Low-Grade Serous Ovarian Cancers to MEK Inhibition
Open the PDF for NOTCH Signaling Limits the Response of Low-Grade Serous Ovarian Cancers to MEK Inhibition in another window
Includes: Supplementary data
Journal Articles

PIM Kinases Are a Potential Prognostic Biomarker and Therapeutic Target in Neuroblastoma

Diede Brunen, Romy C. de Vries, Cor Lieftink, Roderick L. Beijersbergen, René Bernards
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (4): 849–857.
https://doi.org/10.1158/1535-7163.MCT-17-0868
Published: 01 April 2018
View article titled, PIM Kinases Are a Potential Prognostic Biomarker and Therapeutic Target in Neuroblastoma
Open the PDF for PIM Kinases Are a Potential Prognostic Biomarker and Therapeutic Target in Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract IA10: Finding vulnerabilities of drug resistant cancers

René Bernards
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (10_Supplement): IA10.
https://doi.org/10.1158/1538-8514.SYNTHLETH-IA10
Published: 02 October 2017
View article titled, Abstract IA10: Finding vulnerabilities of drug resistant cancers
Journal Articles

Abstract LB-B07: MiSL: a method for mining synthetic lethal partners of somatic mutations identifies acetyl-CoA carboxylase as a synthetic lethal interactor of the IDH1 mutation in Leukemia

Subarna Sinha, Daniel Thomas, Yang Gao, Steven M. Chan, Diede Brunen, Rene Bernards, Ravindra Majeti, David L. Dill
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): LB-B07.
https://doi.org/10.1158/1535-7163.TARG-15-LB-B07
Published: 01 December 2015
View article titled, Abstract LB-B07: MiSL: a method for mining synthetic lethal partners of somatic mutations identifies acetyl-CoA carboxylase as a synthetic lethal interactor of the IDH1 mutation in Leukemia
Journal Articles

Abstract A130: Joint cell-line (CCLE, Sanger) and patient (TCGA) modeling of drug sensitivity reveals novel molecular biomarkers for targeted therapy and conventional chemotherapy.

Charles Ferté, Elias Chaibub Neto, Chong Sun, Cecilia Noecker, Frederic Commo, Olga Nikolova, In Sock Jang, Mehmet Gonen, Benjamin Besse, Fabrice André, Eric Angevin, Ludovic Lacroix, Clement Mazoyer, Antoine Hollebecque, Christophe Massard, Adam Margolin, Roderick Beijersbergen, Stephen Friend, Rene Bernards, Jean-Charles Soria, Justin Guinney
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): A130.
https://doi.org/10.1158/1535-7163.TARG-13-A130
Published: 01 November 2013
View article titled, Abstract A130: Joint cell-line (CCLE, Sanger) and patient (TCGA) modeling of drug sensitivity reveals novel molecular biomarkers for targeted therapy and conventional chemotherapy.
Journal Articles

Abstract PL01-01: Using synthetic lethality to find effective combination therapies for cancer.

René Bernards
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): PL01-01.
https://doi.org/10.1158/1535-7163.TARG-13-PL01-01
Published: 01 November 2013
View article titled, Abstract PL01-01: Using synthetic lethality to find effective combination therapies for cancer.
Journal Articles

Analysis of the 70-gene breast cancer prognosis signature in a general hospital population.

Ben Wittner, Dennis Sgroi, Paula Ryan, Tako Bruinsma, Annuska Glas, Anitha Male, Sonika Dahiya, Karleen Habin, Rene Bernards, Daniel Haber, Laura van 't Veer, Sridhar Ramaswamy
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B174.
Published: 01 November 2007
View article titled, Analysis of the 70-gene breast cancer prognosis signature in a general hospital population.
Journal Articles

Biomarkers of Resistance to Cancer Therapy Discovered through Functional Genetic Screens

Rene Bernards
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): CN02-01.
Published: 01 November 2007
View article titled, Biomarkers of Resistance to Cancer Therapy Discovered through Functional Genetic Screens