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Razelle Kurzrock
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Journal Articles

Cancer-Immunity Marker RNA Expression Levels across Gynecologic Cancers: Implications for Immunotherapy

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Jessica Jou, Shumei Kato, Hirotaka Miyashita, Kartheeswaran Thangathurai, Sarabjot Pabla, Paul DePietro, Mary K. Nesline, Jeffrey M. Conroy, Eitan Rubin, Ramez N. Eskander, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (11): 1352–1362.
https://doi.org/10.1158/1535-7163.MCT-23-0270
Published: 01 November 2023
View articletitled, Cancer-Immunity Marker RNA Expression Levels across Gynecologic Cancers: Implications for Immunotherapy
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Includes: Supplementary data
Journal Articles

JAK: Not Just Another Kinase

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Ruchi P. Agashe, Scott M. Lippman, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (12): 1757–1764.
https://doi.org/10.1158/1535-7163.MCT-22-0323
Published: 02 December 2022
View articletitled, JAK: Not Just Another Kinase
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Journal Articles

Variable Mutation Expression in Human Cancers: A “Hide-and-Seek” Mechanism Linked to Differential MHC-I Presentation Dynamics

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Amélie Boichard, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (7): 1219–1226.
https://doi.org/10.1158/1535-7163.MCT-21-0831
Published: 05 July 2022
View articletitled, Variable Mutation Expression in Human Cancers: A “Hide-and-Seek” Mechanism Linked to Differential MHC-I Presentation Dynamics
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Includes: Supplementary data
Journal Articles

SMARCA4: Implications of an Altered Chromatin-Remodeling Gene for Cancer Development and Therapy

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Kristina Mardinian, Jacob J. Adashek, Gregory P. Botta, Shumei Kato, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12): 2341–2351.
https://doi.org/10.1158/1535-7163.MCT-21-0433
Published: 03 December 2021
View articletitled, SMARCA4: Implications of an Altered Chromatin-Remodeling Gene for Cancer Development and Therapy
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Journal Articles

Genome-wide Sequencing of Cell-free DNA Enables Detection of Copy-number Alterations in Patients with Cancer Where Tissue Biopsy is Not Feasible

Open Access
Taylor J. Jensen, Aaron M. Goodman, Christopher K. Ellison, Kimberly A. Holden, Shumei Kato, Lisa Kim, Gregory A. Daniels, Kerry Fitzgerald, Erin McCarthy, Prachi Nakashe, Amin R. Mazloom, Eyad Almasri, Graham McLennan, Daniel S. Grosu, Marcia Eisenberg, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (11): 2274–2279.
https://doi.org/10.1158/1535-7163.MCT-20-1066
Published: 01 November 2021
View articletitled, Genome-wide Sequencing of Cell-free DNA Enables Detection of Copy-number Alterations in Patients with Cancer Where Tissue Biopsy is Not Feasible
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Journal Articles

BRAF V600E/V600K Mutations versus Nonstandard Alterations: Prognostic Implications and Therapeutic Outcomes

Free
Mina Nikanjam, Jose Tinajero, Donald A. Barkauskas, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (6): 1072–1079.
https://doi.org/10.1158/1535-7163.MCT-20-0861
Published: 01 June 2021
View articletitled, BRAF V600E/V600K Mutations versus Nonstandard Alterations: Prognostic Implications and Therapeutic Outcomes
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Journal Articles

Survival Implications of the Relationship between Tissue versus Circulating Tumor DNA TP53 Mutations—A Perspective from a Real-World Precision Medicine Cohort

Free
Shai Rosenberg, Ryosuke Okamura, Shumei Kato, Thierry Soussi, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2020) 19 (12): 2612–2620.
https://doi.org/10.1158/1535-7163.MCT-20-0097
Published: 02 December 2020
View articletitled, Survival Implications of the Relationship between Tissue versus Circulating Tumor DNA TP53 Mutations—A Perspective from a Real-World Precision Medicine Cohort
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Includes: Supplementary data
Journal Articles

High Tumor Mutational Burden Correlates with Longer Survival in Immunotherapy-Naïve Patients with Diverse Cancers

Free
Paul Riviere, Aaron M. Goodman, Ryosuke Okamura, Donald A. Barkauskas, Theresa J. Whitchurch, Suzanna Lee, Noor Khalid, Rachel Collier, Manvita Mareboina, Garrett M. Frampton, David Fabrizio, Andrew B. Sharabi, Shumei Kato, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2020) 19 (10): 2139–2145.
https://doi.org/10.1158/1535-7163.MCT-20-0161
Published: 02 October 2020
View articletitled, High Tumor Mutational Burden Correlates with Longer Survival in Immunotherapy-Naïve Patients with Diverse Cancers
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Includes: Supplementary data
Journal Articles

Genomic Profiling of Blood-Derived Circulating Tumor DNA from Patients with Colorectal Cancer: Implications for Response and Resistance to Targeted Therapeutics

Free
In Sil Choi, Shumei Kato, Paul T. Fanta, Lawrence Leichman, Ryosuke Okamura, Victoria M. Raymond, Richard B. Lanman, Scott M. Lippman, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2019) 18 (10): 1852–1862.
https://doi.org/10.1158/1535-7163.MCT-18-0965
Published: 01 October 2019
View articletitled, Genomic Profiling of Blood-Derived Circulating Tumor DNA from Patients with Colorectal Cancer: Implications for Response and Resistance to Targeted Therapeutics
Open the PDF for Genomic Profiling of Blood-Derived Circulating Tumor DNA from Patients with Colorectal Cancer: Implications for Response and Resistance to Targeted Therapeutics in another window
Includes: Supplementary data
Journal Articles

Molecular Profiling of Tumor Tissue and Plasma Cell-Free DNA from Patients with Non-Langerhans Cell Histiocytosis

Available to Purchase
Filip Janku, Eli L. Diamond, Aaron M. Goodman, Vaijayanthi Kandadai Raghavan, Tamara G. Barnes, Shumei Kato, Omar Abdel-Wahab, Benjamin H. Durham, Funda Meric-Bernstam, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (6): 1149–1157.
https://doi.org/10.1158/1535-7163.MCT-18-1244
Published: 03 June 2019
View articletitled, Molecular Profiling of Tumor Tissue and Plasma Cell-Free DNA from Patients with Non-Langerhans Cell Histiocytosis
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Journal Articles

Next-Generation Sequencing of Tissue and Circulating Tumor DNA: The UC San Diego Moores Center for Personalized Cancer Therapy Experience with Breast Malignancies

Free
Rebecca Shatsky, Barbara A. Parker, Nam Q. Bui, Teresa Helsten, Richard B. Schwab, Sarah G Boles, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2019) 18 (5): 1001–1011.
https://doi.org/10.1158/1535-7163.MCT-17-1038
Published: 01 May 2019
View articletitled, Next-Generation Sequencing of Tissue and Circulating Tumor DNA: The UC San Diego Moores Center for Personalized Cancer Therapy Experience with Breast Malignancies
Open the PDF for Next-Generation Sequencing of Tissue and Circulating Tumor DNA: The UC San Diego Moores Center for Personalized Cancer Therapy Experience with Breast Malignancies in another window
Includes: Supplementary data
Journal Articles

Genome-Wide Sequencing of Cell-Free DNA Identifies Copy-Number Alterations That Can Be Used for Monitoring Response to Immunotherapy in Cancer Patients

Free
Taylor J. Jensen, Aaron M. Goodman, Shumei Kato, Christopher K. Ellison, Gregory A. Daniels, Lisa Kim, Prachi Nakashe, Erin McCarthy, Amin R. Mazloom, Graham McLennan, Daniel S. Grosu, Mathias Ehrich, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2019) 18 (2): 448–458.
https://doi.org/10.1158/1535-7163.MCT-18-0535
Published: 04 February 2019
View articletitled, Genome-Wide Sequencing of Cell-Free DNA Identifies Copy-Number Alterations That Can Be Used for Monitoring Response to Immunotherapy in Cancer Patients
Open the PDF for Genome-Wide Sequencing of Cell-Free DNA Identifies Copy-Number Alterations That Can Be Used for Monitoring Response to Immunotherapy in Cancer Patients in another window
Includes: Supplementary data
Journal Articles

Analysis of Tissue and Circulating Tumor DNA by Next-Generation Sequencing of Hepatocellular Carcinoma: Implications for Targeted Therapeutics

Available to Purchase
Sadakatsu Ikeda, Jordan S. Lim, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (5): 1114–1122.
https://doi.org/10.1158/1535-7163.MCT-17-0604
Published: 30 April 2018
View articletitled, Analysis of Tissue and Circulating Tumor DNA by Next-Generation Sequencing of Hepatocellular Carcinoma: Implications for Targeted Therapeutics
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Includes: Supplementary data
Journal Articles

Abstract LB-A07: Clinical utility of genomic assessment of blood-derived circulating tumor (ctDNA) in patients with colorectal cancers

Free
Maria C. Schwaederle, Shumei Kato, In Sil Choi, Paul T. Fanta, Lawrence Leichman, Scott Lippman, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): LB-A07.
https://doi.org/10.1158/1535-7163.TARG-17-LB-A07
Published: 01 January 2018
View articletitled, Abstract LB-A07: Clinical utility of genomic assessment of blood-derived circulating tumor (ctDNA) in patients with colorectal cancers
Journal Articles

The Mutational Landscape of Gastrointestinal Malignancies as Reflected by Circulating Tumor DNA

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Paul Riviere, Paul T. Fanta, Sadakatsu Ikeda, Joel Baumgartner, Gregory M. Heestand, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1): 297–305.
https://doi.org/10.1158/1535-7163.MCT-17-0360
Published: 01 January 2018
View articletitled, The Mutational Landscape of Gastrointestinal Malignancies as Reflected by Circulating Tumor DNA
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Includes: Supplementary data
Journal Articles

Path toward Precision Oncology: Review of Targeted Therapy Studies and Tools to Aid in Defining “Actionability” of a Molecular Lesion and Patient Management Support

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Young Kwang Chae, Alan P. Pan, Andrew A. Davis, Sandip P. Patel, Benedito A. Carneiro, Razelle Kurzrock, Francis J. Giles
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (12): 2645–2655.
https://doi.org/10.1158/1535-7163.MCT-17-0597
Published: 03 December 2017
View articletitled, Path toward Precision Oncology: Review of Targeted Therapy Studies and Tools to Aid in Defining “Actionability” of a Molecular Lesion and Patient Management Support
Open the PDF for Path toward Precision Oncology: Review of Targeted Therapy Studies and Tools to Aid in Defining “Actionability” of a Molecular Lesion and Patient Management Support in another window
Journal Articles

Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers

Free
Aaron M. Goodman, Shumei Kato, Lyudmila Bazhenova, Sandip P. Patel, Garrett M. Frampton, Vincent Miller, Philip J. Stephens, Gregory A. Daniels, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2017) 16 (11): 2598–2608.
https://doi.org/10.1158/1535-7163.MCT-17-0386
Published: 01 November 2017
View articletitled, Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers
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Includes: Supplementary data
Journal Articles

Cell-Free DNA from Ascites and Pleural Effusions: Molecular Insights into Genomic Aberrations and Disease Biology

Free
Hatim Husain, David Nykin, Nam Bui, Daniel Quan, German Gomez, Brian Woodward, Sumathi Venkatapathy, Radha Duttagupta, Eric Fung, Scott M. Lippman, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2017) 16 (5): 948–955.
https://doi.org/10.1158/1535-7163.MCT-16-0436
Published: 02 May 2017
View articletitled, Cell-Free DNA from Ascites and Pleural Effusions: Molecular Insights into Genomic Aberrations and Disease Biology
Open the PDF for Cell-Free DNA from Ascites and Pleural Effusions: Molecular Insights into Genomic Aberrations and Disease Biology in another window
Includes: Supplementary data
Journal Articles

Strategies to Overcome Bypass Mechanisms Mediating Clinical Resistance to EGFR Tyrosine Kinase Inhibition in Lung Cancer

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Hatim Husain, Michael Scur, Ayesha Murtuza, Nam Bui, Brian Woodward, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (2): 265–272.
https://doi.org/10.1158/1535-7163.MCT-16-0105
Published: 02 February 2017
View articletitled, Strategies to Overcome Bypass Mechanisms Mediating Clinical Resistance to EGFR Tyrosine Kinase Inhibition in Lung Cancer
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Journal Articles

Genomic Landscape of Malignant Mesotheliomas

Free
Shumei Kato, Brett N. Tomson, Timon P.H. Buys, Sheryl K. Elkin, Jennifer L. Carter, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2016) 15 (10): 2498–2507.
https://doi.org/10.1158/1535-7163.MCT-16-0229
Published: 02 October 2016
View articletitled, Genomic Landscape of Malignant Mesotheliomas
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Includes: Supplementary data