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Philip L. Lorenzi
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Journal Articles

Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer

Susmita Ghosh, Fan Fan, Reid T. Powell, Jason Roszik, Yong Sung Park, Clifford Stephan, Manu Sebastian, Lin Tan, Alexey V. Sorokin, Philip L. Lorenzi, Scott Kopetz, Lee M. Ellis, Rajat Bhattacharya
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (8): 962–975.
https://doi.org/10.1158/1535-7163.MCT-23-0110
Published: 01 August 2023
View article titled, Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Targeting Glutamine Metabolism with a Novel Na+/K+-ATPase Inhibitor RX108 in Hepatocellular Carcinoma

Daoyan Wei, Dongmei Chen, Hongyuan Mou, Sharmistha Chakraborty, Bo Wei, Lin Tan, Philip L. Lorenzi, Xiangping Qian, Peiying Yang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (6): 693–705.
https://doi.org/10.1158/1535-7163.MCT-22-0490
Published: 01 June 2023
View article titled, Targeting Glutamine Metabolism with a Novel Na<sup>+</sup>/K<sup>+</sup>-ATPase Inhibitor RX108 in Hepatocellular Carcinoma
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Includes: Supplementary data
Journal Articles

The Glutaminase Inhibitor CB-839 (Telaglenastat) Enhances the Antimelanoma Activity of T-Cell–Mediated Immunotherapies

Sruthy Varghese, Snigdha Pramanik, Leila J. Williams, Hannah R. Hodges, Courtney W. Hudgens, Grant M. Fischer, Catherine K. Luo, Barbara Knighton, Lin Tan, Philip L. Lorenzi, Andrew L. Mackinnon, Jennifer L. McQuade, Yared Hailemichael, Jason Roszik, Weiyi Peng, Y.N. Vashisht Gopal
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (3): 500–511.
https://doi.org/10.1158/1535-7163.MCT-20-0430
Published: 02 March 2021
View article titled, The Glutaminase Inhibitor CB-839 (Telaglenastat) Enhances the Antimelanoma Activity of T-Cell–Mediated Immunotherapies
Open the PDF for The Glutaminase Inhibitor CB-839 (Telaglenastat) Enhances the Antimelanoma Activity of T-Cell–Mediated Immunotherapies in another window
Includes: Supplementary data
Journal Articles

Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia

Wai-Kin Chan, Thomas D. Horvath, Lin Tan, Todd Link, Karine G. Harutyunyan, Michael A. Pontikos, Andriy Anishkin, Di Du, Leona A. Martin, Eric Yin, Susan B. Rempe, Sergei Sukharev, Marina Konopleva, John N. Weinstein, Philip L. Lorenzi
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2019) 18 (9): 1587–1592.
https://doi.org/10.1158/1535-7163.MCT-18-1329
Published: 03 September 2019
View article titled, Glutaminase Activity of <sc>L</sc>-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia
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Includes: Supplementary data
Journal Articles

Abstract C199: Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules.

Huifang Guo, Meng Gao, Yiling Lu, Jiyong Liang, Philip L. Lorenzi, Shanshan Bai, David H. Hawke, Jie Li, Turgut Dogruluk, Kenneth L. Scott, Eric Jonasch, Gordon B. Mills, Zhiyong Ding
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): C199.
https://doi.org/10.1158/1535-7163.TARG-13-C199
Published: 01 November 2013
View article titled, Abstract C199: Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules.
Journal Articles

DNA fingerprinting of the NCI-60 cell line panel

Philip L. Lorenzi, William C. Reinhold, Sudhir Varma, Amy A. Hutchinson, Yves Pommier, Stephen J. Chanock, John N. Weinstein
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (4): 713–724.
https://doi.org/10.1158/1535-7163.MCT-08-0921
Published: 16 April 2009
View article titled, DNA fingerprinting of the NCI-60 cell line panel
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Includes: Supplementary data
Journal Articles

Asparagine synthetase is a predictive biomarker of l-asparaginase activity in ovarian cancer cell lines

Philip L. Lorenzi, Jenny Llamas, Michele Gunsior, Laurent Ozbun, William C. Reinhold, Sudhir Varma, Helen Ji, Hijoo Kim, Amy A. Hutchinson, Elise C. Kohn, Paul K. Goldsmith, Michael J. Birrer, John N. Weinstein
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (10): 3123–3128.
https://doi.org/10.1158/1535-7163.MCT-08-0589
Published: 13 October 2008
View article titled, Asparagine synthetase is a predictive biomarker of <sc>l</sc>-asparaginase activity in ovarian cancer cell lines
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Includes: Supplementary data
Journal Articles

MicroRNA expression profiles for the NCI-60 cancer cell panel

Paul E. Blower, Joseph S. Verducci, Shili Lin, Jin Zhou, Ji-Hyun Chung, Zunyan Dai, Chang-Gong Liu, William Reinhold, Philip L. Lorenzi, Eric P. Kaldjian, Carlo M. Croce, John N. Weinstein, Wolfgang Sadee
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (5): 1483–1491.
https://doi.org/10.1158/1535-7163.MCT-07-0009
Published: 18 May 2007
View article titled, MicroRNA expression profiles for the NCI-60 cancer cell panel
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Includes: Supplementary data
Journal Articles

Asparagine synthetase as a causal, predictive biomarker for l-asparaginase activity in ovarian cancer cells

Philip L. Lorenzi, William C. Reinhold, Martina Rudelius, Michele Gunsior, Uma Shankavaram, Kimberly J. Bussey, Uwe Scherf, Gabriel S. Eichler, Scott E. Martin, Koei Chin, Joe W. Gray, Elise C. Kohn, Ivan D. Horak, Daniel D. Von Hoff, Mark Raffeld, Paul K. Goldsmith, Natasha J. Caplen, John N. Weinstein
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2006) 5 (11): 2613–2623.
https://doi.org/10.1158/1535-7163.MCT-06-0447
Published: 22 November 2006
View article titled, Asparagine synthetase as a causal, predictive biomarker for <sc>l</sc>-asparaginase activity in ovarian cancer cells
Open the PDF for Asparagine synthetase as a causal, predictive biomarker for <sc>l</sc>-asparaginase activity in ovarian cancer cells in another window