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Journal Articles

Anticancer Efficacy of KRASG12C Inhibitors Is Potentiated by PAK4 Inhibitor KPT9274 in Preclinical Models of KRASG12C-Mutant Pancreatic and Lung Cancers

Husain Yar Khan, Misako Nagasaka, Amro Aboukameel, Osama Alkhalili, Md. Hafiz Uddin, Sahar F. Bannoura, Yousef Mzannar, Ibrahim Azar, Eliza W. Beal, Miguel E. Tobon, Steve H. Kim, Rafic Beydoun, Erkan Baloglu, William Senapedis, Bassel F. El-Rayes, Philip A. Philip, Ramzi M. Mohammad, Anthony F. Shields, Mohammed Najeeb Al Hallak, Asfar S. Azmi
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12): 1422–1433.
https://doi.org/10.1158/1535-7163.MCT-23-0251
Published: 01 December 2023
View article titled, Anticancer Efficacy of KRAS<sup>G12C</sup> Inhibitors Is Potentiated by PAK4 Inhibitor KPT9274 in Preclinical Models of <em>KRAS</em><sup>G12C</sup>-Mutant Pancreatic and Lung Cancers
Open the PDF for Anticancer Efficacy of KRAS<sup>G12C</sup> Inhibitors Is Potentiated by PAK4 Inhibitor KPT9274 in Preclinical Models of <em>KRAS</em><sup>G12C</sup>-Mutant Pancreatic and Lung Cancers in another window
Includes: Supplementary data
Journal Articles

Association of Homologous Recombination–DNA Damage Response Gene Mutations with Immune Biomarkers in Gastroesophageal Cancers

Michael Cerniglia, Joanne Xiu, Axel Grothey, Michael J. Pishvaian, Yasmine Baca, Jimmy J. Hwang, John L. Marshall, Ari M. VanderWalde, Anthony F. Shields, Heinz-Josef Lenz, W. Michael Korn, Mohamed Salem, Philip A. Philip, Richard M. Goldberg, Jia Zeng, Sunnie S. Kim
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (1): 227–236.
https://doi.org/10.1158/1535-7163.MCT-20-0879
Published: 07 January 2022
View article titled, Association of Homologous Recombination–DNA Damage Response Gene Mutations with Immune Biomarkers in Gastroesophageal Cancers
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Includes: Supplementary data
Journal Articles

PAK4-NAMPT Dual Inhibition Sensitizes Pancreatic Neuroendocrine Tumors to Everolimus

Gabriel B. Mpilla, Md. Hafiz Uddin, Mohammed N. Al-Hallak, Amro Aboukameel, Yiwei Li, Steve H. Kim, Rafic Beydoun, Gregory Dyson, Erkan Baloglu, William T. Senapedis, Yosef Landesman, Kay-Uwe Wagner, Nerissa T. Viola, Bassel F. El-Rayes, Philip A. Philip, Ramzi M. Mohammad, Asfar S. Azmi
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (10): 1836–1845.
https://doi.org/10.1158/1535-7163.MCT-20-1105
Published: 01 October 2021
View article titled, PAK4-NAMPT Dual Inhibition Sensitizes Pancreatic Neuroendocrine Tumors to Everolimus
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Includes: Supplementary data
Journal Articles

Molecular Characterization of Appendiceal Goblet Cell Carcinoid

Hiroyuki Arai, Yasmine Baca, Francesca Battaglin, Natsuko Kawanishi, Jingyuan Wang, Shivani Soni, Wu Zhang, Joshua Millstein, Curtis Johnston, Richard M. Goldberg, Philip A. Philip, Andreas Seeber, Joanne Xiu, Jimmy J. Hwang, Anthony F. Shields, John L. Marshall, W. Michael Korn, Heinz-Josef Lenz
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2020) 19 (12): 2634–2640.
https://doi.org/10.1158/1535-7163.MCT-20-0318
Published: 02 December 2020
View article titled, Molecular Characterization of Appendiceal Goblet Cell Carcinoid
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Includes: Supplementary data
Journal Articles

Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma

Amro Aboukameel, Irfana Muqbil, William Senapedis, Erkan Baloglu, Yosef Landesman, Sharon Shacham, Michael Kauffman, Philip A. Philip, Ramzi M. Mohammad, Asfar S. Azmi
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (1): 76–87.
https://doi.org/10.1158/1535-7163.MCT-16-0205
Published: 05 January 2017
View article titled, Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma
Open the PDF for Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Proof of Concept: Network and Systems Biology Approaches Aid in the Discovery of Potent Anticancer Drug Combinations

Asfar S. Azmi, Zhiwei Wang, Philip A. Philip, Ramzi M. Mohammad, Fazlul H. Sarkar
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (12): 3137–3144.
https://doi.org/10.1158/1535-7163.MCT-10-0642
Published: 14 December 2010
View article titled, Proof of Concept: Network and Systems Biology Approaches Aid in the Discovery of Potent Anticancer Drug Combinations
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Journal Articles

Apoptosis-inducing effect of erlotinib is potentiated by 3,3′-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer

Shadan Ali, Sanjeev Banerjee, Aamir Ahmad, Bassel F. El-Rayes, Philip A. Philip, Fazlul H. Sarkar
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (6): 1708–1719.
https://doi.org/10.1158/1535-7163.MCT-08-0354
Published: 19 June 2008
View article titled, Apoptosis-inducing effect of erlotinib is potentiated by 3,3′-diindolylmethane <em>in vitro</em> and <em>in vivo</em> using an orthotopic model of pancreatic cancer
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Journal Articles

Inactivation of NF-κB by 3,3′-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cells

KM Wahidur Rahman, Shadan Ali, Amro Aboukameel, Sanila H. Sarkar, Zhiwei Wang, Philip A. Philip, Wael A. Sakr, Avraham Raz
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (10): 2757–2765.
https://doi.org/10.1158/1535-7163.MCT-07-0336
Published: 15 October 2007
View article titled, Inactivation of NF-κB by 3,3′-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cells
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Journal Articles

Simultaneous targeting of the epidermal growth factor receptor and cyclooxygenase-2 pathways for pancreatic cancer therapy

Shadan Ali, Basil F. El-Rayes, Fazlul H. Sarkar, Philip A. Philip
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2005) 4 (12): 1943–1951.
https://doi.org/10.1158/1535-7163.MCT-05-0065
Published: 22 December 2005
View article titled, Simultaneous targeting of the epidermal growth factor receptor and cyclooxygenase-2 pathways for pancreatic cancer therapy
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Journal Articles

Cyclooxygenase-2-dependent and -independent effects of celecoxib in pancreatic cancer cell lines

Basil F. El-Rayes, Shadan Ali, Fazlul H. Sarkar, Philip A. Philip
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2004) 3 (11): 1421–1426.
https://doi.org/10.1158/1535-7163.1421.3.11
Published: 12 November 2004
View article titled, Cyclooxygenase-2-dependent and -independent effects of celecoxib in pancreatic cancer cell lines
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