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Paul E. Hughes
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Journal Articles

Abstract B080: Non-genetic determinants driving sub-clonal resistance to KRAS G12C combination therapies in KRAS mutant non-small cell lung cancer

Free
Chendi Li, Christopher J Graser, Qian Qin, Usman M Syed, Barbara Karakyriakou, Sarah E Clark, Anne Y Saiki, Paul E Hughes, Christopher Ott, Luca Pinello, Franziska Michor, Aaron N Hata
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): B080.
https://doi.org/10.1158/1535-7163.TARG-23-B080
Published: 01 December 2023
View articletitled, Abstract B080: Non-genetic determinants driving sub-clonal resistance to KRAS G12C combination therapies in KRAS mutant non-small cell lung cancer
Journal Articles

Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic–Resistant AML and AML Stem Cells

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Bing Z. Carter, Po Yee Mak, Wenjing Tao, Qi Zhang, Vivian Ruvolo, Vinitha M. Kuruvilla, Xiangmeng Wang, Duncan H. Mak, Venkata L. Battula, Marina Konopleva, Elias J. Jabbour, Paul E. Hughes, Xiaoyue Chen, Phuong K. Morrow, Michael Andreeff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (6): 879–889.
https://doi.org/10.1158/1535-7163.MCT-21-0690
Published: 01 June 2022
View articletitled, Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic–Resistant AML and AML Stem Cells
Open the PDF for Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic–Resistant AML and AML Stem Cells in another window
Includes: Supplementary data
Journal Articles

In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models

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Paul E. Hughes, Karen Rex, Sean Caenepeel, Yajing Yang, Yihong Zhang, Martin A. Broome, Hue T. Kha, Teresa L. Burgess, Benny Amore, Paula J. Kaplan-Lefko, Jodi Moriguchi, Jonathan Werner, Michael A. Damore, Daniel Baker, Deborah M. Choquette, Jean-Christophe Harmange, Robert Radinsky, Richard Kendall, Isabelle Dussault, Angela Coxon
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (7): 1568–1579.
https://doi.org/10.1158/1535-7163.MCT-15-0871
Published: 05 July 2016
View articletitled, In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models
Open the PDF for In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models in another window
Includes: Supplementary data