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Journal Articles

Editor's Note: Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress–Inducing Drugs

Laurence Booth, Jane L. Roberts, Nichola Cruickshanks, Steven Grant, Andrew Poklepovic, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (9): 1669.
https://doi.org/10.1158/1535-7163.MCT-19-0666
Published: 03 September 2019
View articletitled, Editor's Note: Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress–Inducing Drugs
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Journal Articles

Retraction: Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells In Vitro and In Vivo

Girija Dasmahapatra, Dmitry Lembersky, Minkyeong P. Son, Hiral Patel, Derick Peterson, Elisa Attkisson, Richard I. Fisher, Jonathan W. Friedberg, Paul Dent, Steven Grant
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (6): 1180.
https://doi.org/10.1158/1535-7163.MCT-19-0470
Published: 03 June 2019
View articletitled, Retraction: Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells In Vitro and In Vivo
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Journal Articles

Retraction: Carfilzomib Interacts Synergistically with Histone Deacetylase Inhibitors in Mantle Cell Lymphoma Cells In Vitro and In Vivo

Girija Dasmahapatra, Dmitry Lembersky, Minkyeong P. Son, Elisa Attkisson, Paul Dent, Richard I. Fisher, Jonathan W. Friedberg, Steven Grant
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (6): 1179.
https://doi.org/10.1158/1535-7163.MCT-19-0469
Published: 03 June 2019
View articletitled, Retraction: Carfilzomib Interacts Synergistically with Histone Deacetylase Inhibitors in Mantle Cell Lymphoma Cells In Vitro and In Vivo
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Journal Articles

Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress–Inducing Drugs

Laurence Booth, Jane L. Roberts, Nichola Cruickshanks, Steven Grant, Andrew Poklepovic, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2014) 13 (10): 2384–2398.
https://doi.org/10.1158/1535-7163.MCT-14-0172
Published: 02 October 2014
View articletitled, Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress–Inducing Drugs
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Journal Articles

Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells In Vitro and In Vivo

Girija Dasmahapatra, Dmitry Lembersky, Minkyeong P. Son, Hiral Patel, Derick Peterson, Elisa Attkisson, Richard I. Fisher, Jonathan W. Friedberg, Paul Dent, Steven Grant
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (5): 1122–1132.
https://doi.org/10.1158/1535-7163.MCT-12-0021
Published: 08 May 2012
View articletitled, Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells In Vitro and In Vivo
Open the PDF for Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells In Vitro and In Vivo in another window
Includes: Supplementary data
Journal Articles

Carfilzomib Interacts Synergistically with Histone Deacetylase Inhibitors in Mantle Cell Lymphoma Cells In Vitro and In Vivo

Girija Dasmahapatra, Dmitry Lembersky, Minkyeong P. Son, Elisa Attkisson, Paul Dent, Richard I. Fisher, Jonathan W. Friedberg, Steven Grant
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (9): 1686–1697.
https://doi.org/10.1158/1535-7163.MCT-10-1108
Published: 07 September 2011
View articletitled, Carfilzomib Interacts Synergistically with Histone Deacetylase Inhibitors in Mantle Cell Lymphoma Cells In Vitro and In Vivo
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Includes: Supplementary data
Journal Articles

Sorafenib Activates CD95 and Promotes Autophagy and Cell Death via Src Family Kinases in Gastrointestinal Tumor Cells

Margaret A. Park, Roland Reinehr, Dieter Häussinger, Christina Voelkel-Johnson, Besim Ogretmen, Adly Yacoub, Steven Grant, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (8): 2220–2231.
https://doi.org/10.1158/1535-7163.MCT-10-0274
Published: 09 August 2010
View articletitled, Sorafenib Activates CD95 and Promotes Autophagy and Cell Death via Src Family Kinases in Gastrointestinal Tumor Cells
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Includes: Supplementary data
Journal Articles

17-Allylamino-17-Demethoxygeldanamycin and MEK1/2 Inhibitors Kill GI Tumor Cells via Ca2+-Dependent Suppression of GRP78/BiP and Induction of Ceramide and Reactive Oxygen Species

Teneille Walker, Clint Mitchell, Margaret A. Park, Adly Yacoub, Mohamed Rahmani, Dieter Häussinger, Roland Reinehr, Christina Voelkel-Johnson, Paul B. Fisher, Steven Grant, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (5): 1378–1395.
https://doi.org/10.1158/1535-7163.MCT-09-1131
Published: 09 May 2010
View articletitled, 17-Allylamino-17-Demethoxygeldanamycin and MEK1/2 Inhibitors Kill GI Tumor Cells via Ca2+-Dependent Suppression of GRP78/BiP and Induction of Ceramide and Reactive Oxygen Species
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Includes: Supplementary data
Journal Articles

Astrocyte Elevated Gene-1: A Novel Target for Human Glioma Therapy

Luni Emdad, Devanand Sarkar, Seok-Geun Lee, Zhao Zhong Su, Byoung Kwon Yoo, Rupesh Dash, Adly Yacoub, Christine E. Fuller, Khalid Shah, Paul Dent, Jeffrey N. Bruce, Paul B. Fisher
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (1): 79–88.
https://doi.org/10.1158/1535-7163.MCT-09-0752
Published: 12 January 2010
View articletitled, Astrocyte Elevated Gene-1: A Novel Target for Human Glioma Therapy
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Journal Articles

MDA-7/IL-24–induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK–dependent mechanism

Margaret A. Park, Teneille Walker, Aditi Pandya Martin, Jeremy Allegood, Nicollaq Vozhilla, Luni Emdad, Devanand Sarkar, Mohammed Rahmani, Martin Graf, Adly Yacoub, Costas Koumenis, Sarah Spiegel, David T. Curiel, Christina Voelkel-Johnson, Steven Grant, Paul B. Fisher, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (5): 1280–1291.
https://doi.org/10.1158/1535-7163.MCT-09-0073
Published: 13 May 2009
View articletitled, MDA-7/IL-24–induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK–dependent mechanism
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Includes: Supplementary data
Journal Articles

Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions

Roberto R. Rosato, Jorge A. Almenara, Sonia C. Maggio, Stefanie Coe, Peter Atadja, Paul Dent, Steven Grant
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (10): 3285–3297.
https://doi.org/10.1158/1535-7163.MCT-08-0385
Published: 13 October 2008
View articletitled, Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions
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Includes: Supplementary data
Journal Articles

Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95

Margaret A. Park, Guo Zhang, Clint Mitchell, Mohamed Rahmani, Hossein Hamed, Michael P. Hagan, Adly Yacoub, David T. Curiel, Paul B. Fisher, Steven Grant, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (9): 2633–2648.
https://doi.org/10.1158/1535-7163.MCT-08-0400
Published: 11 September 2008
View articletitled, Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95
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Includes: Supplementary data
Journal Articles

Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis

Irina V. Lebedeva, Zhao-zhong Su, Nichollaq Vozhilla, Lejuan Chatman, Devanand Sarkar, Paul Dent, Mohammad Athar, Paul B. Fisher
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (7): 2042–2050.
https://doi.org/10.1158/1535-7163.MCT-08-0245
Published: 21 July 2008
View articletitled, Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis
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Journal Articles

Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo

Hossein Hamed, William Hawkins, Clint Mitchell, Donna Gilfor, Guo Zhang, Xin-Yan Pei, Yun Dai, Michael P. Hagan, John D. Roberts, Adly Yacoub, Steven Grant, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (3): 616–629.
https://doi.org/10.1158/1535-7163.MCT-07-2376
Published: 17 March 2008
View articletitled, Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo
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Journal Articles

Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells

Adly Yacoub, Margaret A. Park, Pankaj Gupta, Mohammed Rahmani, Guo Zhang, Hossein Hamed, David Hanna, Devanand Sarkar, Irina V. Lebedeva, Luni Emdad, Moira Sauane, Nicollaq Vozhilla, Sarah Spiegel, Costas Koumenis, Martin Graf, David T. Curiel, Steven Grant, Paul B. Fisher, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (2): 297–313.
https://doi.org/10.1158/1535-7163.MCT-07-2166
Published: 15 February 2008
View articletitled, Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells
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Journal Articles

Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling

Adly Yacoub, Pankaj Gupta, Margaret A. Park, Mohammed Rhamani, Hossein Hamed, David Hanna, Guo Zhang, Devanand Sarkar, Irina V. Lebedeva, Luni Emdad, Costas Koumenis, David T. Curiel, Steven Grant, Paul B. Fisher, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (2): 314–329.
https://doi.org/10.1158/1535-7163.MCT-07-2150
Published: 15 February 2008
View articletitled, Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling
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Journal Articles

Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells

Clint Mitchell, Maragret A. Park, Guo Zhang, Adly Yacoub, David T. Curiel, Paul B. Fisher, John D. Roberts, Steven Grant, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (12): 3101–3112.
https://doi.org/10.1158/1535-7163.MCT-07-0561
Published: 18 December 2007
View articletitled, Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells
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Journal Articles

Melanoma differentiation associated gene-7/interleukin-24 reverses multidrug resistance in human colorectal cancer cells

Luni Emdad, Irina V. Lebedeva, Zao-Zhong Su, Devanand Sarkar, Paul Dent, David T. Curiel, Paul B. Fisher
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11): 2985–2994.
https://doi.org/10.1158/1535-7163.MCT-07-0399
Published: 19 November 2007
View articletitled, Melanoma differentiation associated gene-7/interleukin-24 reverses multidrug resistance in human colorectal cancer cells
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Journal Articles

Platinum-based drug cytotoxicity is enhanced by the antidepressant desipramine.

Nicholas Farrell, Peyman Kabolizadeh, John Ryan, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): C237.
Published: 01 November 2007
View articletitled, Platinum-based drug cytotoxicity is enhanced by the antidepressant desipramine.
Journal Articles

Ras-dependent activation of ERK1/2 regulates the lethality of Chk1 inhibitors in multiple myeloma cells

Yun Dai, Shuang Chen, Xin-Yan Pei, Jorge Almenara, Lora Kramer, Charis Venditti, Paul Dent, Steven Grant
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): C180.
Published: 01 November 2007
View articletitled, Ras-dependent activation of ERK1/2 regulates the lethality of Chk1 inhibitors in multiple myeloma cells