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Nicolas Guilbaud
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Journal Articles

The DNA-Binding Polyamine Moiety in the Vectorized DNA Topoisomerase II Inhibitor F14512 Alters Reparability of the Consequent Enzyme-Linked DNA Double-Strand Breaks

Oriane Bombarde, Florence Larminat, Dennis Gomez, Philippe Frit, Carine Racca, Bruno Gomes, Nicolas Guilbaud, Patrick Calsou
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (10): 2166–2177.
https://doi.org/10.1158/1535-7163.MCT-16-0767
Published: 02 October 2017
View article titled, The DNA-Binding Polyamine Moiety in the Vectorized DNA Topoisomerase II Inhibitor F14512 Alters Reparability of the Consequent Enzyme-Linked DNA Double-Strand Breaks
Open the PDF for The DNA-Binding Polyamine Moiety in the Vectorized DNA Topoisomerase II Inhibitor F14512 Alters Reparability of the Consequent Enzyme-Linked DNA Double-Strand Breaks in another window
Includes: Supplementary data
Journal Articles

Abstract B37: F14512, a polyamine-vectorized anticancer drug, triggers senescence cell death mechanism.

Viviane Brel, J-Philippe Annereau, Bruno Gomes, Isabelle Vandenberghe, Karine Andre, Marie-Laure Marionneau, Laurence Lacastaigneratte, Aline Stennevin, Jerome Rouquet, Alain Latil, Anna Kruczynski, Christian Bailly, Nicolas Guilbaud
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): B37.
https://doi.org/10.1158/1535-7163.TARG-11-B37
Published: 12 November 2011
View article titled, Abstract B37: F14512, a polyamine-vectorized anticancer drug, triggers senescence cell death mechanism.
Journal Articles

Abstract A214: F14512, a novel targeted cytotoxic agent exhibits a marked antileukemic activity, alone and in combination with AraC.

Anna Kruczynski, Arnaud Pillon, Laurent Creancier, Isabelle Vandenberghe, Bruno Gomes, Jean-Philippe Annereau, Emmanuel Fournier, Jean-Emmanuel Sarry, Cécile Demur, Eric Delabesse, Sandrine Pourtau, Valérie Cartron, Fabien Marty, Sabine Roy, Nathalie Chansard, Jean-Christophe Blanchet, Jérôme Verdier, Christel Ricome, Vanessa Offrete, Stéphane Gras, Yves Guminski, Christian Recher, Christian Bailly, Nicolas Guilbaud
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): A214.
https://doi.org/10.1158/1535-7163.TARG-11-A214
Published: 12 November 2011
View article titled, Abstract A214: F14512, a novel targeted cytotoxic agent exhibits a marked antileukemic activity, alone and in combination with AraC.
Journal Articles

Abstract CN08-03: Targeting topoisomerase II inhibitors to cancer cells via the polyamines transport system

Christian Bailly, Anna Kruczynski, Jean‐Marc Barret, Yves Guminski, Thierry Imbert, Nicolas Guilbaud
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): CN08-03.
https://doi.org/10.1158/1535-7163.TARG-09-CN08-03
Published: 10 December 2009
View article titled, Abstract CN08-03: Targeting topoisomerase II inhibitors to cancer cells via the polyamines transport system
Journal Articles

Abstract B186: Preclinical antileukemic activity of F14512, a novel targeted cytotoxic agent

Anna Kruczynski, Christian Recher, Sandrine Pourtau, Valérie Cartron, Fabien Marty, Isabelle Vandenberghe, Nathalie Chansard, Nathalie Gallay, Arnaud Pillon, Sabrina Pesnel, Alain Le Pape, Laurent Créancier, Yoann Menon, Bruno Gomes, Jean‐Christophe Blanchet, Christel Ricome, Yves Guminski, Thierry Imbert, Bernard Payrastre, Christian Bailly, Cécile Demur, Nicolas Guilbaud
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): B186.
https://doi.org/10.1158/1535-7163.TARG-09-B186
Published: 10 December 2009
View article titled, Abstract B186: Preclinical antileukemic activity of F14512, a novel targeted cytotoxic agent
Journal Articles

Abstract A87: Synthesis and structure‐activity relationships of a series of epipodophyllotoxin polyamine conjugated derivatives vectorized for active polyamine transporter system in tumor cells, leading to the selection of F14512 for clinical trials

Thierry Imbert, Yves Guminski, Sandrine Cugnasse, Martial Grousseaud, Jean‐Marc Barret, Anna Kruczynski, Stéphane Vispe, Stéphane Gras, Jean‐Philippe Annereau, Isabelle Vandenberghe, Aline Stennevin, Laurence Lacastaignaratte, Natacha Novosad, Sandrine Pourtau, Sabine Roy, Caroline Castano, Jean‐Christophe Blanchet, Nicolas Guilbaud, Christian Bailly
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): A87.
https://doi.org/10.1158/1535-7163.TARG-09-A87
Published: 10 December 2009
View article titled, Abstract A87: Synthesis and structure‐activity relationships of a series of epipodophyllotoxin polyamine conjugated derivatives vectorized for active polyamine transporter system in tumor cells, leading to the selection of F14512 for clinical trials
Journal Articles

Triptolide is an inhibitor of RNA polymerase I and II–dependent transcription leading predominantly to down-regulation of short-lived mRNA

Stéphane Vispé, Luc DeVries, Laurent Créancier, Jérome Besse, Sophie Bréand, David J. Hobson, Jesper Q. Svejstrup, Jean-Philippe Annereau, Didier Cussac, Charles Dumontet, Nicolas Guilbaud, Jean-Marc Barret, Christian Bailly
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (10): 2780–2790.
https://doi.org/10.1158/1535-7163.MCT-09-0549
Published: 12 October 2009
View article titled, Triptolide is an inhibitor of RNA polymerase I and II–dependent transcription leading predominantly to down-regulation of short-lived mRNA
Open the PDF for Triptolide is an inhibitor of RNA polymerase I and II–dependent transcription leading predominantly to down-regulation of short-lived mRNA in another window
Includes: Supplementary data
Journal Articles

F14512, a novel targeted cytotoxic agent with a potent and selective antiproliferative activity against cancer cells expressing a high level of polyamine transport system

Jean-Philippe Annereau, Jean-Marc Barret, Viviane Brel, Aline Stennevin, Karine Andre, Marie-Laure Marionneau, Vanessa Offrete, Anna Kruczynski, Yves Guminski, Thierry Imbert, Nicolas Guilbaud, Christian Bailly
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): A274.
Published: 01 November 2007
View article titled, F14512, a novel targeted cytotoxic agent with a potent and selective antiproliferative activity against cancer cells expressing a high level of polyamine transport system
Journal Articles

Tumor cell-selective DNA damaging activity of the targeted cytotoxic agent F14512

Stephane Vispe, Jean-Marc Barret, Stephane Gras, Amelie Lansiaux, Brigitte Baldeyrou, Jerome Filiol, Natacha Novosad, Vanessa Offrete, Yoann Menon, Yves Guminski, Thierry Imbert, Nicolas Guilbaud, Christian Bailly
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): A273.
Published: 01 November 2007
View article titled, Tumor cell-selective DNA damaging activity of the targeted cytotoxic agent F14512
Journal Articles

Preclinical antitumor activity of F14512, a novel targeted cytotoxic agent

Anna Kruczynski, Isabelle Vandenberghe, Vanessa Tillement, Christel Ricome, Sandrine Pourtau, Valerie Faure, Sabine Roy, Jean-Christophe Blanchet, Caroline Castano, Nathalie Chansard, Jean-Marc Barret, Jean-Philippe Annereau, Yves Guminski, Thierry Imbert, Nicolas Guilbaud, Christian Bailly
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): A276.
Published: 01 November 2007
View article titled, Preclinical antitumor activity of F14512, a novel targeted cytotoxic agent
Journal Articles

F14512, a novel targeted cytotoxic agent vectored into cells via the polyamine transport system

Jean-Marc Barret, Jean-Guy Delcros, Stephane Vispe, Jean-Philippe Annereau, Viviane Brel, Karine Andre, Aline Stennevin, Yves Guminski, Thierry Imbert, Nicolas Guilbaud, Christian Bailly
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): A270.
Published: 01 November 2007
View article titled, F14512, a novel targeted cytotoxic agent vectored into cells via the polyamine transport system
Journal Articles

Tumor penetration of gefitinib (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor

David McKillop, Elizabeth A. Partridge, John V. Kemp, Mike P. Spence, Jane Kendrew, Sharon Barnett, Phillippa G. Wood, Petrina B. Giles, Andrew B. Patterson, Francis Bichat, Nicolas Guilbaud, Trevor C. Stephens
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2005) 4 (4): 641–649.
https://doi.org/10.1158/1535-7163.MCT-04-0329
Published: 12 April 2005
View article titled, Tumor penetration of gefitinib (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor
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