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Naoto T. Ueno
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Journal Articles

Targeting CDK7 Enhances the Antitumor Efficacy of Enzalutamide in Androgen Receptor–Positive Triple-Negative Breast Cancer by Inhibiting c-MYC–mediated Tumorigenesis

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Xuemei Xie, Maroua Manai, Dileep R. Rampa, Jon A. Fuson, Elizabeth S. Nakasone, Troy Pearson, Bharat S. Kuntal, Debu Tripathy, Naoto T. Ueno, Jangsoon Lee
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2025) 24 (6): 870–883.
https://doi.org/10.1158/1535-7163.MCT-23-0386
Published: 04 June 2025
View articletitled, Targeting CDK7 Enhances the Antitumor Efficacy of Enzalutamide in Androgen Receptor–Positive Triple-Negative Breast Cancer by Inhibiting c-MYC–mediated Tumorigenesis
Open the PDF for Targeting CDK7 Enhances the Antitumor Efficacy of Enzalutamide in Androgen Receptor–Positive Triple-Negative Breast Cancer by Inhibiting c-MYC–mediated Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

Inhibition of MCL-1 and MEK Overcomes MEK Inhibitor Resistance in Triple-Negative and Inflammatory Breast Cancers

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Mohd Mughees, Moises Tacam, Alex W. Tan, Mary Kathryn Pitner, Lakesla R. Iles, Xiaoding Hu, Emilly S. Villodre, Bisrat G. Debeb, Takahiro Kogawa, Bora Lim, Rachel M. Layman, Wendy A. Woodward, Naoto T. Ueno, Debu Tripathy, Savitri Krishnamurthy, Yuan Qi, Lajos Pusztai, Jian Wang, Varsha Gandhi, Geoffrey Bartholomeusz, Chandra Bartholomeusz
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther OF1–OF13.
https://doi.org/10.1158/1535-7163.MCT-24-0593
Published: 30 May 2025
View articletitled, Inhibition of MCL-1 and MEK Overcomes MEK Inhibitor Resistance in Triple-Negative and Inflammatory Breast Cancers
Open the PDF for Inhibition of MCL-1 and MEK Overcomes MEK Inhibitor Resistance in Triple-Negative and Inflammatory Breast Cancers in another window
Includes: Supplementary data
Journal Articles

Abstract C146: VIC-1911, a selective Aurora kinase A inhibitor, synergizes with sacituzumab govitecan in triple-negative breast cancer

Free
Jangsoon Lee, YoungJin Gi, Thomas Myers, Linda Paradiso, Debu Tripathy, Naoto T. Ueno
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): C146.
https://doi.org/10.1158/1535-7163.TARG-23-C146
Published: 01 December 2023
View articletitled, Abstract C146: VIC-1911, a selective Aurora kinase A inhibitor, synergizes with sacituzumab govitecan in triple-negative breast cancer
Journal Articles

An Enzymatically Cleavable Tripeptide Linker for Maximizing the Therapeutic Index of Antibody–Drug Conjugates

Available to Purchase
Summer Y.Y. Ha, Yasuaki Anami, Chisato M. Yamazaki, Wei Xiong, Candice M. Haase, Scott D. Olson, Jangsoon Lee, Naoto T. Ueno, Ningyan Zhang, Zhiqiang An, Kyoji Tsuchikama
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (9): 1449–1461.
https://doi.org/10.1158/1535-7163.MCT-22-0362
Published: 06 September 2022
View articletitled, An Enzymatically Cleavable Tripeptide Linker for Maximizing the Therapeutic Index of Antibody–Drug Conjugates
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Includes: Supplementary data
Journal Articles

Abstract P132: Promotion of E-cadherin-mediated tumor cell adhesion by COX-2/GSK3b signaling is a targetable mechanism of metastatic breast cancer

Free
Balamurugan Kuppusamy, Saadiya Sehareen, Savitri Krishnamurthy, Shikha Sharana, Wei Tang, Naoto T. Ueno, Stefan Ambs, Dipak K. Poria, Esta Sternecka
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P132.
https://doi.org/10.1158/1535-7163.TARG-21-P132
Published: 01 December 2021
View articletitled, Abstract P132: Promotion of E-cadherin-mediated tumor cell adhesion by COX-2/GSK3b signaling is a targetable mechanism of metastatic breast cancer
Journal Articles

Birinapant Enhances Gemcitabine's Antitumor Efficacy in Triple-Negative Breast Cancer by Inducing Intrinsic Pathway–Dependent Apoptosis

Free
Xuemei Xie, Jangsoon Lee, Huey Liu, Troy Pearson, Alexander Y. Lu, Debu Tripathy, Gayathri R. Devi, Chandra Bartholomeusz, Naoto T. Ueno
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (2): 296–306.
https://doi.org/10.1158/1535-7163.MCT-19-1160
Published: 05 February 2021
View articletitled, Birinapant Enhances Gemcitabine's Antitumor Efficacy in Triple-Negative Breast Cancer by Inducing Intrinsic Pathway–Dependent Apoptosis
Open the PDF for Birinapant Enhances Gemcitabine's Antitumor Efficacy in Triple-Negative Breast Cancer by Inducing Intrinsic Pathway–Dependent Apoptosis in another window
Includes: Supplementary data
Journal Articles

Cooperative Effect of Oncogenic MET and PIK3CA in an HGF-Dominant Environment in Breast Cancer

Free
Shuying Liu, Shunqiang Li, Bailiang Wang, Wenbin Liu, Mihai Gagea, Huiqin Chen, Joohyuk Sohn, Napa Parinyanitikul, Tina Primeau, Kim-Anh Do, George F. Vande Woude, John Mendelsohn, Naoto T. Ueno, Gordon B. Mills, Debu Tripathy, Ana M. Gonzalez-Angulo
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2019) 18 (2): 399–412.
https://doi.org/10.1158/1535-7163.MCT-18-0710
Published: 04 February 2019
View articletitled, Cooperative Effect of Oncogenic MET and PIK3CA in an HGF-Dominant Environment in Breast Cancer
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Includes: Supplementary data
Journal Articles

ST8SIA1 Regulates Tumor Growth and Metastasis in TNBC by Activating the FAK–AKT–mTOR Signaling Pathway

Free
Khoa Nguyen, Yuanqing Yan, Bin Yuan, Abhishek Dasgupta, Jeffrey Sun, Hong Mu, Kim-Anh Do, Naoto T. Ueno, Michael Andreeff, V. Lokesh Battula
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (12): 2689–2701.
https://doi.org/10.1158/1535-7163.MCT-18-0399
Published: 03 December 2018
View articletitled, ST8SIA1 Regulates Tumor Growth and Metastasis in TNBC by Activating the FAK–AKT–mTOR Signaling Pathway
Open the PDF for ST8SIA1 Regulates Tumor Growth and Metastasis in TNBC by Activating the FAK–AKT–mTOR Signaling Pathway in another window
Includes: Supplementary data
Journal Articles

Abstract LB-B28: Abietane natural products as novel therapeutics against solid tumors

Free
Walter Lang, Taotao Ling, Jangsoon Lee, Naoto T. Ueno, Fatima Rivas
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): LB-B28.
https://doi.org/10.1158/1535-7163.TARG-17-LB-B28
Published: 01 January 2018
View articletitled, Abstract LB-B28: Abietane natural products as novel therapeutics against solid tumors
Journal Articles

MEK Inhibitor Selumetinib (AZD6244; ARRY-142886) Prevents Lung Metastasis in a Triple-Negative Breast Cancer Xenograft Model

Free
Chandra Bartholomeusz, Xuemei Xie, Mary Kathryn Pitner, Kimie Kondo, Ali Dadbin, Jangsoon Lee, Hitomi Saso, Paul D. Smith, Kevin N. Dalby, Naoto T. Ueno
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2015) 14 (12): 2773–2781.
https://doi.org/10.1158/1535-7163.MCT-15-0243
Published: 06 December 2015
View articletitled, MEK Inhibitor Selumetinib (AZD6244; ARRY-142886) Prevents Lung Metastasis in a Triple-Negative Breast Cancer Xenograft Model
Open the PDF for MEK Inhibitor Selumetinib (AZD6244; ARRY-142886) Prevents Lung Metastasis in a Triple-Negative Breast Cancer Xenograft Model in another window
Includes: Supplementary data
Journal Articles

Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases

Free
Kazuharu Kai, Kimie Kondo, Xiaoping Wang, Xuemei Xie, Mary K. Pitner, Monica E. Reyes, Angie M. Torres-Adorno, Hiroko Masuda, Gabriel N. Hortobagyi, Chandra Bartholomeusz, Hideyuki Saya, Debu Tripathy, Subrata Sen, Naoto T. Ueno
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12): 2687–2699.
https://doi.org/10.1158/1535-7163.MCT-15-0096
Published: 06 December 2015
View articletitled, Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases
Open the PDF for Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases in another window
Includes: Supplementary data
Journal Articles

Abstract B51: ApoStream™ isolated circulating tumor cells from primary breast cancer patients reveals heterogeneous phenotypes related to epithelial-mesenchymal transition and stem cell markers.

Free
Kenna L. Anderes, Insiya Jafferji, Vladislava O. Melnikova, Jackson A. Summer, Darren W. Davis, James M. Reuben, Naoto T. Ueno
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): B51.
https://doi.org/10.1158/1535-7163.TARG-13-B51
Published: 01 November 2013
View articletitled, Abstract B51: ApoStream™ isolated circulating tumor cells from primary breast cancer patients reveals heterogeneous phenotypes related to epithelial-mesenchymal transition and stem cell markers.
Journal Articles

Bisphosphorylated PEA-15 Sensitizes Ovarian Cancer Cells to Paclitaxel by Impairing the Microtubule-Destabilizing Effect of SCLIP

Free
Xuemei Xie, Chandra Bartholomeusz, Ahmed A. Ahmed, Anna Kazansky, Lixia Diao, Keith A. Baggerly, Gabriel N. Hortobagyi, Naoto T. Ueno
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (6): 1099–1111.
https://doi.org/10.1158/1535-7163.MCT-12-0737
Published: 09 June 2013
View articletitled, Bisphosphorylated PEA-15 Sensitizes Ovarian Cancer Cells to Paclitaxel by Impairing the Microtubule-Destabilizing Effect of SCLIP
Open the PDF for Bisphosphorylated PEA-15 Sensitizes Ovarian Cancer Cells to Paclitaxel by Impairing the Microtubule-Destabilizing Effect of SCLIP in another window
Includes: Supplementary data
Journal Articles

Epithelial–Mesenchymal Transition and Stem Cell Markers in Patients with HER2-Positive Metastatic Breast Cancer

Free
Antonio Giordano, Hui Gao, Simone Anfossi, Evan Cohen, Michal Mego, Bang-Ning Lee, Sanda Tin, Michele De Laurentiis, Charla A. Parker, Ricardo H. Alvarez, Vicente Valero, Naoto T. Ueno, Sabino De Placido, Sendurai A. Mani, Francisco J. Esteva, Massimo Cristofanilli, James M. Reuben
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (11): 2526–2534.
https://doi.org/10.1158/1535-7163.MCT-12-0460
Published: 08 November 2012
View articletitled, Epithelial–Mesenchymal Transition and Stem Cell Markers in Patients with HER2-Positive Metastatic Breast Cancer
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Includes: Supplementary data
Journal Articles

MEK1/2 Inhibitor Selumetinib (AZD6244) Inhibits Growth of Ovarian Clear Cell Carcinoma in a PEA-15–Dependent Manner in a Mouse Xenograft Model

Free
Chandra Bartholomeusz, Tetsuro Oishi, Hitomi Saso, Ugur Akar, Ping Liu, Kimie Kondo, Anna Kazansky, Savitri Krishnamurthy, Jangsoon Lee, Francisco J. Esteva, Junzo Kigawa, Naoto T. Ueno
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (2): 360–369.
https://doi.org/10.1158/1535-7163.MCT-11-0400
Published: 08 February 2012
View articletitled, MEK1/2 Inhibitor Selumetinib (AZD6244) Inhibits Growth of Ovarian Clear Cell Carcinoma in a PEA-15–Dependent Manner in a Mouse Xenograft Model
Open the PDF for MEK1/2 Inhibitor Selumetinib (AZD6244) Inhibits Growth of Ovarian Clear Cell Carcinoma in a PEA-15–Dependent Manner in a Mouse Xenograft Model in another window
Journal Articles

Silencing Kinase-Interacting Stathmin Gene Enhances Erlotinib Sensitivity by Inhibiting Ser10 p27 Phosphorylation in Epidermal Growth Factor Receptor–Expressing Breast Cancer

Free
Dongwei Zhang, Ana M. Tari, Ugur Akar, Banu K. Arun, Tiffany A. LaFortune, Rene Nieves-Alicea, Gabriel N. Hortobagyi, Naoto T. Ueno
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (11): 3090–3099.
https://doi.org/10.1158/1535-7163.MCT-10-0362
Published: 09 November 2010
View articletitled, Silencing Kinase-Interacting Stathmin Gene Enhances Erlotinib Sensitivity by Inhibiting Ser10 p27 Phosphorylation in Epidermal Growth Factor Receptor–Expressing Breast Cancer
Open the PDF for Silencing Kinase-Interacting Stathmin Gene Enhances Erlotinib Sensitivity by Inhibiting Ser10 p27 Phosphorylation in Epidermal Growth Factor Receptor–Expressing Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Targeting p70S6K Prevented Lung Metastasis in a Breast Cancer Xenograft Model

Free
Ugur Akar, Bulent Ozpolat, Kapil Mehta, Gabriel Lopez-Berestein, Dongwei Zhang, Naoto T. Ueno, Gabriel N. Hortobagyi, Banu Arun
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (5): 1180–1187.
https://doi.org/10.1158/1535-7163.MCT-09-1025
Published: 09 May 2010
View articletitled, Targeting p70S6K Prevented Lung Metastasis in a Breast Cancer Xenograft Model
Open the PDF for Targeting p70S6K Prevented Lung Metastasis in a Breast Cancer Xenograft Model in another window
Journal Articles

A novel hTERT promoter–driven E1A therapeutic for ovarian cancer

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Xiaoming Xie, Jennifer L. Hsu, Min-Gew Choi, Weiya Xia, Hirohito Yamaguchi, Chun-Te Chen, Bon Q. Trinh, Zhen Lu, Naoto T. Ueno, Judith K. Wolf, Robert C. Bast, Jr., Mien-Chie Hung
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (8): 2375–2382.
https://doi.org/10.1158/1535-7163.MCT-09-0056
Published: 14 August 2009
View articletitled, A novel hTERT promoter–driven E1A therapeutic for ovarian cancer
Open the PDF for A novel hTERT promoter–driven E1A therapeutic for ovarian cancer in another window
Includes: Supplementary data
Journal Articles

Activity of lapatinib is independent of EGFR expression level in HER2-overexpressing breast cancer cells

Free
Dongwei Zhang, Ashutosh Pal, William G. Bornmann, Fumiyuki Yamasaki, Francisco J. Esteva, Gabriel N. Hortobagyi, Chandra Bartholomeusz, Naoto T. Ueno
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (7): 1846–1850.
https://doi.org/10.1158/1535-7163.MCT-08-0168
Published: 21 July 2008
View articletitled, Activity of lapatinib is independent of EGFR expression level in HER2-overexpressing breast cancer cells
Open the PDF for Activity of lapatinib is independent of EGFR expression level in HER2-overexpressing breast cancer cells in another window
Journal Articles

Sensitivity of breast cancer cells to erlotinib depends on cyclin-dependent kinase 2 activity

Free
Fumiyuki Yamasaki, Dongwei Zhang, Chandra Bartholomeusz, Tamotsu Sudo, Gabriel N. Hortobagyi, Kaoru Kurisu, Naoto T. Ueno
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (8): 2168–2177.
https://doi.org/10.1158/1535-7163.MCT-06-0514
Published: 15 August 2007
View articletitled, Sensitivity of breast cancer cells to erlotinib depends on cyclin-dependent kinase 2 activity
Open the PDF for Sensitivity of breast cancer cells to erlotinib depends on cyclin-dependent kinase 2 activity in another window