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Michael Andreeff
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Journal Articles

Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic–Resistant AML and AML Stem Cells

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Bing Z. Carter, Po Yee Mak, Wenjing Tao, Qi Zhang, Vivian Ruvolo, Vinitha M. Kuruvilla, Xiangmeng Wang, Duncan H. Mak, Venkata L. Battula, Marina Konopleva, Elias J. Jabbour, Paul E. Hughes, Xiaoyue Chen, Phuong K. Morrow, Michael Andreeff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (6): 879–889.
https://doi.org/10.1158/1535-7163.MCT-21-0690
Published: 01 June 2022
View articletitled, Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic–Resistant AML and AML Stem Cells
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Includes: Supplementary data
Journal Articles

Abstract CC09-01: Targeting BCL-XL/BCL-2 by PROTAC 753b effectively eliminates AML cells and enhances efficacy of chemotherapy by targeting senescent cells

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Yannan Jia, Qi Zhang, Weiguo Zhang, Michael Andreeff, Nitin Jain, Helen Ma, Peiyi Zhang, Guangrong Zheng, Daohong Zhou, Marina Konopleva
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): CC09-01.
https://doi.org/10.1158/1535-7163.TARG-21-CC09-01
Published: 01 December 2021
View articletitled, Abstract CC09-01: Targeting BCL-XL/BCL-2 by PROTAC 753b effectively eliminates AML cells and enhances efficacy of chemotherapy by targeting senescent cells
Journal Articles

Combinatorial Inhibition of Focal Adhesion Kinase and BCL-2 Enhances Antileukemia Activity of Venetoclax in Acute Myeloid Leukemia

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Xiangmeng Wang, Po Yee Mak, Hong Mu, Wenjing Tao, Arvind Rao, Ravikumar Visweswaran, Vivian Ruvolo, Jonathan A. Pachter, David T. Weaver, Michael Andreeff, Bing Xu, Bing Z. Carter
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2020) 19 (8): 1636–1648.
https://doi.org/10.1158/1535-7163.MCT-19-0841
Published: 04 August 2020
View articletitled, Combinatorial Inhibition of Focal Adhesion Kinase and BCL-2 Enhances Antileukemia Activity of Venetoclax in Acute Myeloid Leukemia
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Includes: Supplementary data
Journal Articles

ST8SIA1 Regulates Tumor Growth and Metastasis in TNBC by Activating the FAK–AKT–mTOR Signaling Pathway

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Khoa Nguyen, Yuanqing Yan, Bin Yuan, Abhishek Dasgupta, Jeffrey Sun, Hong Mu, Kim-Anh Do, Naoto T. Ueno, Michael Andreeff, V. Lokesh Battula
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (12): 2689–2701.
https://doi.org/10.1158/1535-7163.MCT-18-0399
Published: 03 December 2018
View articletitled, ST8SIA1 Regulates Tumor Growth and Metastasis in TNBC by Activating the FAK–AKT–mTOR Signaling Pathway
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Includes: Supplementary data
Journal Articles

Focal Adhesion Kinase as a Potential Target in AML and MDS

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Bing Z. Carter, Po Yee Mak, Xiangmeng Wang, Hui Yang, Guillermo Garcia-Manero, Duncan H. Mak, Hong Mu, Vivian R. Ruvolo, Yihua Qiu, Kevin Coombes, Nianxiang Zhang, Brittany Ragon, David T. Weaver, Jonathan A. Pachter, Steven Kornblau, Michael Andreeff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (6): 1133–1144.
https://doi.org/10.1158/1535-7163.MCT-16-0719
Published: 01 June 2017
View articletitled, Focal Adhesion Kinase as a Potential Target in AML and MDS
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Includes: Supplementary data
Journal Articles

Abstract PL07-01: Altered metabolism in leukemic microenvironment

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Marina Y. Konopleva, Tomasz Zal, Niki M. Zacharias Millward, Byoung-Sik Cho, Karine Harutyunyan, Anna Zal, Hong Mu, Sergej Konoplev, Juliana Benito, Juliana Velez, Carlos Bueso-Ramso, Jennifer Molina, Pratip K. Bhattacharya, Maria Emilia Di Francesco, Joseph Marszalek, Michael Andreeff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): PL07-01.
https://doi.org/10.1158/1535-7163.TARG-15-PL07-01
Published: 01 December 2015
View articletitled, Abstract PL07-01: Altered metabolism in leukemic microenvironment
Journal Articles

Abstract B1: Gene expression and TP53 mutation analysis predict sensitivity of leukemia cells to MDM2 inhibition by DS-3032b

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Jo Ishizawa, Kenji Nakamaru, Takahiko Seki, Koichi Tazaki, Kensuke Kojima, Dhruv Chachad, Archie Tse, Arvind Rao, Michael Andreeff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): B1.
https://doi.org/10.1158/1535-7163.TARG-15-B1
Published: 01 December 2015
View articletitled, Abstract B1: Gene expression and TP53 mutation analysis predict sensitivity of leukemia cells to MDM2 inhibition by DS-3032b
Journal Articles

Evaluation of Apoptosis Induction by Concomitant Inhibition of MEK, mTOR, and Bcl-2 in Human Acute Myelogenous Leukemia Cells

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Weiguo Zhang, Vivian R. Ruvolo, Chen Gao, Liran Zhou, William Bornmann, Twee Tsao, Wendy D. Schober, Paul Smith, Sylvie Guichard, Marina Konopleva, Michael Andreeff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2014) 13 (7): 1848–1859.
https://doi.org/10.1158/1535-7163.MCT-13-0576
Published: 06 July 2014
View articletitled, Evaluation of Apoptosis Induction by Concomitant Inhibition of MEK, mTOR, and Bcl-2 in Human Acute Myelogenous Leukemia Cells
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Includes: Supplementary data
Journal Articles

BH3 Profiling Discriminates Response to Cytarabine-Based Treatment of Acute Myelogenous Leukemia

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William E. Pierceall, Steven M. Kornblau, Nicole E. Carlson, Xuelin Huang, Noel Blake, Ryan Lena, Michael Elashoff, Marina Konopleva, Michael H. Cardone, Michael Andreeff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (12): 2940–2949.
https://doi.org/10.1158/1535-7163.MCT-13-0692
Published: 05 December 2013
View articletitled, BH3 Profiling Discriminates Response to Cytarabine-Based Treatment of Acute Myelogenous Leukemia
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Includes: Supplementary data
Journal Articles

The Novel Tryptamine Derivative JNJ-26854165 Induces Wild-Type p53- and E2F1-Mediated Apoptosis in Acute Myeloid and Lymphoid Leukemias

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Kensuke Kojima, Jared K. Burks, Janine Arts, Michael Andreeff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (9): 2545–2557.
https://doi.org/10.1158/1535-7163.MCT-10-0337
Published: 08 September 2010
View articletitled, The Novel Tryptamine Derivative JNJ-26854165 Induces Wild-Type p53- and E2F1-Mediated Apoptosis in Acute Myeloid and Lymphoid Leukemias
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Includes: Supplementary data
Journal Articles

1,25-Dihydroxyvitamin D3 Enhances the Apoptotic Activity of MDM2 Antagonist Nutlin-3a in Acute Myeloid Leukemia Cells Expressing Wild-type p53

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Thelma Thompson, Michael Andreeff, George P. Studzinski, Lyubomir T. Vassilev
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (5): 1158–1168.
https://doi.org/10.1158/1535-7163.MCT-09-1036
Published: 09 May 2010
View articletitled, 1,25-Dihydroxyvitamin D3 Enhances the Apoptotic Activity of MDM2 Antagonist Nutlin-3a in Acute Myeloid Leukemia Cells Expressing Wild-type p53
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Includes: Supplementary data
Journal Articles

Triptolide induces cell death independent of cellular responses to imatinib in blast crisis chronic myelogenous leukemia cells including quiescent CD34+ primitive progenitor cells

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Duncan H. Mak, Wendy D. Schober, Wenjing Chen, Marina Konopleva, Jorge Cortes, Hagop M. Kantarjian, Michael Andreeff, Bing Z. Carter
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (9): 2509–2516.
https://doi.org/10.1158/1535-7163.MCT-09-0386
Published: 17 September 2009
View articletitled, Triptolide induces cell death independent of cellular responses to imatinib in blast crisis chronic myelogenous leukemia cells including quiescent CD34+ primitive progenitor cells
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Journal Articles

Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells

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Ismael Samudio, Svitlana Kurinna, Peter Ruvolo, Borys Korchin, Hagop Kantarjian, Miloslav Beran, Kenneth Dunner, Jr., Seiji Kondo, Michael Andreeff, Marina Konopleva
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (5): 1130–1139.
https://doi.org/10.1158/1535-7163.MCT-07-0553
Published: 15 May 2008
View articletitled, Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells
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Journal Articles

CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells

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Linhua Jin, Yoko Tabe, Sergej Konoplev, Yuanyuan Xu, Clinton E. Leysath, Hongbo Lu, Shinya Kimura, Akimichi Ohsaka, Mary-Beth Rios, Leslie Calvert, Hagop Kantarjian, Michael Andreeff, Marina Konopleva
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (1): 48–58.
https://doi.org/10.1158/1535-7163.MCT-07-0042
Published: 17 January 2008
View articletitled, CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells
Open the PDF for CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells in another window
Journal Articles

Phase I trial with a novel orally administered synthetic triterpenoid RTA 402 (CDDO-Me) in patients with solid tumors and lymphoid malignancies

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David Hong, Razelle Kurzrock, Jeffrey Supko, Donald Lawrence, Jennifer Wheeler, Joseph Eder, Chaan Ng, James Mier, Marina Konopleva, Sergej Konoplev, Suhendan Ekmekcioglu, Michael Andreeff, Elizabeth Grimm, Donald Kufe, Colin Meyer, Geoffrey Shapiro, Bruce Dezube
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B82.
Published: 01 November 2007
View articletitled, Phase I trial with a novel orally administered synthetic triterpenoid RTA 402 (CDDO-Me) in patients with solid tumors and lymphoid malignancies
Journal Articles

Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias

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Zhihong Zeng, Ismael J. Samudio, Mark Munsell, Jing An, Ziwei Huang, Elihu Estey, Michael Andreeff, Marina Konopleva
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2006) 5 (12): 3113–3121.
https://doi.org/10.1158/1535-7163.MCT-06-0228
Published: 15 December 2006
View articletitled, Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias
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Journal Articles

Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells

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Raoul Tibes, YiHua Qiu, Yiling Lu, Bryan Hennessy, Michael Andreeff, Gordon B. Mills, Steven M. Kornblau
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2006) 5 (10): 2512–2521.
https://doi.org/10.1158/1535-7163.MCT-06-0334
Published: 13 October 2006
View articletitled, Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells
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Journal Articles

Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells

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Marina Konopleva, Weiguo Zhang, Yue-Xi Shi, Teresa McQueen, Twee Tsao, Maen Abdelrahim, Mark F. Munsell, Mary Johansen, Dihua Yu, Timothy Madden, Stephen H. Safe, Mien-Chie Hung, Michael Andreeff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2006) 5 (2): 317–328.
https://doi.org/10.1158/1535-7163.MCT-05-0350
Published: 27 February 2006
View articletitled, Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells
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Journal Articles

Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure

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Ismael Samudio, Marina Konopleva, Stephen Safe, Teresa McQueen, Michael Andreeff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2005) 4 (12): 1982–1992.
https://doi.org/10.1158/1535-7163.MCT-05-0247
Published: 22 December 2005
View articletitled, Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure
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Journal Articles

Peroxisome proliferator-activated receptor γ and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias

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Marina Konopleva, Elena Elstner, Teresa J. McQueen, Twee Tsao, Andrey Sudarikov, Wei Hu, Wendy D. Schober, Rui-Yu Wang, David Chism, Steven M. Kornblau, Anas Younes, Steven J. Collins, H. Phillip Koeffler, Michael Andreeff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2004) 3 (10): 1249–1262.
https://doi.org/10.1158/1535-7163.1249.3.10
Published: 14 October 2004
View articletitled, Peroxisome proliferator-activated receptor γ and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias
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