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Melinda G. Hollingshead
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Journal Articles

Abstract P097: Comparative single cell transcriptome profiling of primary tumors, CTCs and metastatic sites from a bladder cancer PDX model

Tomas Vilimas, Brandie Fullmer, Alyssa Chapman, Li Chen, Ting-Chia Chang, Rini Pauly, Biswajit Das, Chris Karlovich, Yvonne A. Evrard, Howard Stotler, Michelle M. Gottholm‐Ahalt, Tara Grinnage-Pulley, Melinda G. Hollingshead, James H. Doroshow, P. Mickey Williams
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P097.
https://doi.org/10.1158/1535-7163.TARG-21-P097
Published: 01 December 2021
View article titled, Abstract P097: Comparative single cell transcriptome profiling of primary tumors, CTCs and metastatic sites from a bladder cancer PDX model
Journal Articles

Isoform- and Phosphorylation-specific Multiplexed Quantitative Pharmacodynamics of Drugs Targeting PI3K and MAPK Signaling in Xenograft Models and Clinical Biopsies

William G. Herrick, Casey L. Kilpatrick, Melinda G. Hollingshead, Dominic Esposito, Geraldine O'Sullivan Coyne, Andrea M. Gross, Barry C. Johnson, Alice P. Chen, Brigitte C. Widemann, James H. Doroshow, Ralph E. Parchment, Apurva K. Srivastava
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2021) 20 (4): 749–760.
https://doi.org/10.1158/1535-7163.MCT-20-0566
Published: 01 April 2021
View article titled, Isoform- and Phosphorylation-specific Multiplexed Quantitative Pharmacodynamics of Drugs Targeting PI3K and MAPK Signaling in Xenograft Models and Clinical Biopsies
Open the PDF for Isoform- and Phosphorylation-specific Multiplexed Quantitative Pharmacodynamics of Drugs Targeting PI3K and MAPK Signaling in Xenograft Models and Clinical Biopsies in another window
Includes: Supplementary data
Journal Articles

F-aza-T-dCyd (NSC801845), a Novel Cytidine Analog, in Comparative Cell Culture and Xenograft Studies with the Clinical Candidates T-dCyd, F-T-dCyd, and Aza-T-dCyd

Joel Morris, Donn G. Wishka, Omar D. Lopez, Vladimir Rudchenko, Guangfei Huang, Sierra N. Hoffman, Suzanne Borgel, Kyle Georgius, John Carter, Howard Stotler, Mark W. Kunkel, Jerry M. Collins, Melinda G. Hollingshead, Beverly A. Teicher
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2021) 20 (4): 625–631.
https://doi.org/10.1158/1535-7163.MCT-20-0738
Published: 01 April 2021
View article titled, F-aza-T-dCyd (NSC801845), a Novel Cytidine Analog, in Comparative Cell Culture and Xenograft Studies with the Clinical Candidates T-dCyd, F-T-dCyd, and Aza-T-dCyd
Open the PDF for F-aza-T-dCyd (NSC801845), a Novel Cytidine Analog, in Comparative Cell Culture and Xenograft Studies with the Clinical Candidates T-dCyd, F-T-dCyd, and Aza-T-dCyd in another window
Includes: Supplementary data
Journal Articles

Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas

Long-Sheng Chang, Janet L. Oblinger, Sarah S. Burns, Jie Huang, Larry W. Anderson, Melinda G. Hollingshead, Rulong Shen, Li Pan, Garima Agarwal, Yulin Ren, Ryan D. Roberts, Barry R. O'Keefe, A. Douglas Kinghorn, Jerry M. Collins
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2020) 19 (3): 731–741.
https://doi.org/10.1158/1535-7163.MCT-19-0809
Published: 02 March 2020
View article titled, Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas
Open the PDF for Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas in another window
Includes: Supplementary data
Journal Articles

Specific RITA Modification Produces Hyperselective Cytotoxicity While Maintaining In Vivo Antitumor Efficacy

Brian D. Peyser, Ann Hermone, Joseph M. Salamoun, James C. Burnett, Melinda G. Hollingshead, Connor F. McGrath, Rick Gussio, Peter Wipf
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (10): 1765–1774.
https://doi.org/10.1158/1535-7163.MCT-19-0185
Published: 01 October 2019
View article titled, Specific RITA Modification Produces Hyperselective Cytotoxicity While Maintaining <em>In Vivo</em> Antitumor Efficacy
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Includes: Supplementary data
Journal Articles

Molecular Pharmacodynamics-Guided Scheduling of Biologically Effective Doses: A Drug Development Paradigm Applied to MET Tyrosine Kinase Inhibitors

Apurva K. Srivastava, Melinda G. Hollingshead, Jeevan Prasaad Govindharajulu, Joseph M. Covey, Dane Liston, Melanie A. Simpson, James O. Peggins, Donald P. Bottaro, John J. Wright, Robert J. Kinders, James H. Doroshow, Ralph E. Parchment
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (3): 698–709.
https://doi.org/10.1158/1535-7163.MCT-17-0552
Published: 28 February 2018
View article titled, Molecular Pharmacodynamics-Guided Scheduling of Biologically Effective Doses: A Drug Development Paradigm Applied to MET Tyrosine Kinase Inhibitors
Open the PDF for Molecular Pharmacodynamics-Guided Scheduling of Biologically Effective Doses: A Drug Development Paradigm Applied to MET Tyrosine Kinase Inhibitors in another window
Includes: Supplementary data
Journal Articles

Abstract LB-B18: Epithelial to mesenchymal transition in human tumor biopsies: Quantitative, histopathological proof of the existence of EMT in vivo by immunofluorescence microscopy

Tony Navas, Robert J. Kinders, Scott M. Lawrence, Katherine Ferry-Galow, Thomas D. Pfister, Apurva K. Srivastava, Sergio Y. Alcoser, Melinda G. Hollingshead, Lindsay M. Dutko, Brad A. Gouker, Donna O. Butcher, Hala Makhlouf, Rodrigo Chuaqui, Donald P. Bottaro, Shivaani Kummar, Alice Chen, James H. Doroshow, Ralph E. Parchment
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): LB-B18.
https://doi.org/10.1158/1535-7163.TARG-15-LB-B18
Published: 01 December 2015
View article titled, Abstract LB-B18: Epithelial to mesenchymal transition in human tumor biopsies: Quantitative, histopathological proof of the existence of EMT in vivo by immunofluorescence microscopy
Journal Articles

Abstract C3: Validation and fitness testing of a quantitative immunoassay for HIF1α in biopsy specimens.

Robert J. Kinders, Sook Ryun Park, Sonny Khin, Melinda G. Hollingshead, Ralph E. Parchment, Joseph E. Tomaszewski, James H. Doroshow
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): C3.
https://doi.org/10.1158/1535-7163.TARG-11-C3
Published: 12 November 2011
View article titled, Abstract C3: Validation and fitness testing of a quantitative immunoassay for HIF1α in biopsy specimens.
Journal Articles

Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells

Lorena de la Peña, William E. Burgan, Donna J. Carter, Melinda G. Hollingshead, Merriline Satyamitra, Kevin Camphausen, Philip J. Tofilon
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2006) 5 (6): 1504–1510.
https://doi.org/10.1158/1535-7163.MCT-06-0091
Published: 03 July 2006
View article titled, Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells
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