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Melanie Valenti
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Journal Articles

Modulation of Plasma Metabolite Biomarkers of the MAPK Pathway with MEK Inhibitor RO4987655: Pharmacodynamic and Predictive Potential in Metastatic Melanoma

Joo Ern Ang, Akos Pal, Yasmin J. Asad, Alan T. Henley, Melanie Valenti, Gary Box, Alexis de haven Brandon, Victoria L. Revell, Debra J. Skene, Miro Venturi, Ruediger Rueger, Valerie Meresse, Suzanne A. Eccles, Johann S. de Bono, Stanley B. Kaye, Paul Workman, Udai Banerji, Florence I. Raynaud
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2017) 16 (10): 2315–2323.
https://doi.org/10.1158/1535-7163.MCT-16-0881
Published: 02 October 2017
View article titled, Modulation of Plasma Metabolite Biomarkers of the MAPK Pathway with MEK Inhibitor RO4987655: Pharmacodynamic and Predictive Potential in Metastatic Melanoma
Open the PDF for Modulation of Plasma Metabolite Biomarkers of the MAPK Pathway with MEK Inhibitor RO4987655: Pharmacodynamic and Predictive Potential in Metastatic Melanoma in another window
Includes: Supplementary data
Journal Articles

Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation

Joo Ern Ang, Rupinder Pandher, Joo Chew Ang, Yasmin J. Asad, Alan T. Henley, Melanie Valenti, Gary Box, Alexis de Haven Brandon, Richard D. Baird, Lori Friedman, Mika Derynck, Bart Vanhaesebroeck, Suzanne A. Eccles, Stan B. Kaye, Paul Workman, Johann S. de Bono, Florence I. Raynaud
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2016) 15 (6): 1412–1424.
https://doi.org/10.1158/1535-7163.MCT-15-0815
Published: 02 June 2016
View article titled, Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation
Open the PDF for Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation in another window
Includes: Supplementary data
Journal Articles

Abstract B74: The dual FLT3-Aurora inhibitor CCT241736 overcomes resistance to selective FLT3 inhibition driven by FLT3 ligand and FLT3 point mutations in acute myeloid leukemia.

Andrew Moore, Amir Faisal, Vassilios Bavetsias, David Gonzalez de Castro, Chongbo Sun, Butrus Atrash, Melanie Valenti, Alexis de Haven Brandon, Sian Avery, Andrew Pearson, Paul Workman, Julian Blagg, Florence Raynaud, Suzanne Eccles, Spiros Linardopoulos
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): B74.
https://doi.org/10.1158/1535-7163.TARG-11-B74
Published: 12 November 2011
View article titled, Abstract B74: The dual FLT3-Aurora inhibitor CCT241736 overcomes resistance to selective FLT3 inhibition driven by FLT3 ligand and FLT3 point mutations in acute myeloid leukemia.
Journal Articles

Abstract A235: Structure-guided evolution of potent and selective oral inhibitors of CHK1 through scaffold morphing.

Thomas P. Matthews, Suki Klair, Kwai-Ming J. Cheung, Jane Scanlon, Michael Lainchbury, Nelly Piton, Martin Fisher, Michael Cherry, Kathy Boxall, Michael I. Walton, Isaac M. Westwood, Angela Hayes, Paul Eve, Melanie Valenti, Alexis de Haven Brandon, Gary Box, Rob L. M. van Montfort, David H. Williams, Wynne Aherne, Florence I. Raynaud, Suzanne A. Eccles, Michelle D. Garrett, John C. Reader, Ian Collins
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): A235.
https://doi.org/10.1158/1535-7163.TARG-11-A235
Published: 12 November 2011
View article titled, Abstract A235: Structure-guided evolution of potent and selective oral inhibitors of CHK1 through scaffold morphing.
Journal Articles

Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β

Aleksandra Bielen, Lara Perryman, Gary M. Box, Melanie Valenti, Alexis de Haven Brandon, Vanessa Martins, Alexa Jury, Sergey Popov, Sharon Gowan, Sebastien Jeay, Florence I. Raynaud, Francesco Hofmann, Darren Hargrave, Suzanne A. Eccles, Chris Jones
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (8): 1407–1418.
https://doi.org/10.1158/1535-7163.MCT-11-0205
Published: 08 August 2011
View article titled, Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β
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Includes: Supplementary data
Journal Articles

Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930

Timothy A. Yap, Mike I. Walton, Lisa-Jane K. Hunter, Melanie Valenti, Alexis de Haven Brandon, Paul D. Eve, Ruth Ruddle, Simon P. Heaton, Alan Henley, Lisa Pickard, Gowri Vijayaraghavan, John J. Caldwell, Neil T. Thompson, Wynne Aherne, Florence I. Raynaud, Suzanne A. Eccles, Paul Workman, Ian Collins, Michelle D. Garrett
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (2): 360–371.
https://doi.org/10.1158/1535-7163.MCT-10-0760
Published: 08 February 2011
View article titled, Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930
Open the PDF for Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930 in another window
Includes: Supplementary data
Journal Articles

The Preclinical Pharmacology and Therapeutic Activity of the Novel CHK1 Inhibitor SAR-020106

Michael I. Walton, Paul D. Eve, Angela Hayes, Melanie Valenti, Alexis De Haven Brandon, Gary Box, Kathy J. Boxall, G. Wynne Aherne, Suzanne A. Eccles, Florence I. Raynaud, David H. Williams, John C. Reader, Ian Collins, Michelle D. Garrett
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (1): 89–100.
https://doi.org/10.1158/1535-7163.MCT-09-0938
Published: 12 January 2010
View article titled, The Preclinical Pharmacology and Therapeutic Activity of the Novel CHK1 Inhibitor SAR-020106
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Includes: Supplementary data
Journal Articles

Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941

Florence I. Raynaud, Suzanne A. Eccles, Sonal Patel, Sonia Alix, Gary Box, Irina Chuckowree, Adrian Folkes, Sharon Gowan, Alexis De Haven Brandon, Francesca Di Stefano, Angela Hayes, Alan T. Henley, Letitia Lensun, Giles Pergl-Wilson, Anthony Robson, Nahid Saghir, Alexander Zhyvoloup, Edward McDonald, Peter Sheldrake, Stephen Shuttleworth, Melanie Valenti, Nan Chi Wan, Paul A. Clarke, Paul Workman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (7): 1725–1738.
https://doi.org/10.1158/1535-7163.MCT-08-1200
Published: 14 July 2009
View article titled, Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Open the PDF for Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941 in another window
Includes: Supplementary data
Journal Articles

Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity

Florence Chan, Chongbo Sun, Meg Perumal, Quang-De Nguyen, Vassilios Bavetsias, Edward McDonald, Vanessa Martins, Nicola E. Wilsher, Florence I. Raynaud, Melanie Valenti, Sue Eccles, Robert te Poele, Paul Workman, Eric O. Aboagye, Spiros Linardopoulos
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (12): 3147–3157.
https://doi.org/10.1158/1535-7163.MCT-07-2156
Published: 18 December 2007
View article titled, Mechanism of action of the Aurora kinase inhibitor CCT129202 and <em>in vivo</em> quantification of biological activity
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Journal Articles

NVP-AUY922, a novel diarylisoxazole resorcinol HSP90 inhibitor, potently inhibits growth and metastasis of human tumor xenografts

Suzanne Eccles, Swee Sharp, Florence Raynaud, Melanie Valenti, Lisa Patterson, Sharon Gowan, Kathy Boxall, Wynne Aherne, Martin Rowlands, Angela Hayes, Vanessa Martins, Federique Urban, Chrisostomos Prodromou, Laurence Pearl, Karen James, Thomas Matthews, Kwai-Ming Cheung, Andrew Kalusa, Keith Jones, Edward McDonald, Paul Brough, Andrew Massey, Brian Dymock, Martin Drysdale, Paul Workman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B284.
Published: 01 November 2007
View article titled, NVP-AUY922, a novel diarylisoxazole resorcinol HSP90 inhibitor, potently inhibits growth and metastasis of human tumor xenografts
Journal Articles

Characterization of CCT129202, a novel Aurora kinase inhibitor and in vivo quantification of biological activity

Florence Chan, Chongbo Sun, Meg Perumal, Quang-De Nguyen, Vassilios Bavetsias, Edward McDonald, Vanessa Martins, Nicola Wilsher, Florence Raynaud, Melanie Valenti, Sue Eccles, Robert tePoele, Paul Workman, Eric Aboagye, Spyridon Linardopoulos
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): A239.
Published: 01 November 2007
View article titled, Characterization of CCT129202, a novel Aurora kinase inhibitor and <em>in vivo</em> quantification of biological activity
Journal Articles

Cassette dosing in tumor bearing animals for the discovery of NVP-AUY922, a novel HSP90 inhibitor.

Florence Raynaud, Angela Hayes, Vanessa Martins, Nicola Smith, Swee Sharp, Melanie Valenti, Alan Henley, Thomas Matthews, Kwai-Ming Cheung, Andrew Kalusa, Keith Jones, Karen James, Edward McDonald, Paul Brough, Andrew Massey, Brian Dymock, Martin Drysdale, Suzanne Eccles, Paul Workman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B289.
Published: 01 November 2007
View article titled, Cassette dosing in tumor bearing animals for the discovery of NVP-AUY922, a novel HSP90 inhibitor.
Journal Articles

Characterization of a potent inhibitor of class 1 phosphatidylinositide-3’-kinases (PI3K) in human glioma

Paul Clarke, Sandrine Guillard, Francesca Di Stefano, Robert te Poele, Melanie Valenti, Alexis de Haven Brandon, Sue Eccles, Florence Raynaud, Paul Workman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): A243.
Published: 01 November 2007
View article titled, Characterization of a potent inhibitor of class 1 phosphatidylinositide-3’-kinases (PI3K) in human glioma
Journal Articles

Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis

Sharon Sanderson, Melanie Valenti, Sharon Gowan, Lisa Patterson, Zahida Ahmad, Paul Workman, Suzanne A. Eccles
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2006) 5 (3): 522–532.
https://doi.org/10.1158/1535-7163.MCT-05-0439
Published: 16 March 2006
View article titled, Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis
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