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Mark J. O'Connor
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Journal Articles

Radiopotentiation Profiling of Multiple Inhibitors of the DNA Damage Response for Early Clinical Development

Sonja J. Gill, Paul W.G. Wijnhoven, Jacqueline H.L. Fok, Rebecca L. Lloyd, Jonathan Cairns, Joshua Armenia, Jenni Nikkilä, Alan Lau, Christopher J. Bakkenist, Susan M. Galbraith, Conchita Vens, Mark J. O'Connor
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (9): 1614–1626.
https://doi.org/10.1158/1535-7163.MCT-20-0502
Published: 01 September 2021
View article titled, Radiopotentiation Profiling of Multiple Inhibitors of the DNA Damage Response for Early Clinical Development
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Journal Articles

Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically

Lucy C. Riches, Antonio G. Trinidad, Gareth Hughes, Gemma N. Jones, Adina M. Hughes, Andrew G. Thomason, Paul Gavine, Andy Cui, Stephanie Ling, Jonathan Stott, Roger Clark, Samantha Peel, Pendeep Gill, Louise M. Goodwin, Aaron Smith, Kurt G. Pike, Bernard Barlaam, Martin Pass, Mark J. O'Connor, Graeme Smith, Elaine B. Cadogan
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2020) 19 (1): 13–25.
https://doi.org/10.1158/1535-7163.MCT-18-1394
Published: 03 January 2020
View article titled, Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically
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Includes: Supplementary data
Journal Articles

Androgen Receptor Inhibitor Enhances the Antitumor Effect of PARP Inhibitor in Breast Cancer Cells by Modulating DNA Damage Response

Ahrum Min, Hyemin Jang, Seongyeong Kim, Kyung-Hun Lee, Debora Keunyoung Kim, Koung Jin Suh, Yaewon Yang, Paul Elvin, Mark J. O'Connor, Seock-Ah Im
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (12): 2507–2518.
https://doi.org/10.1158/1535-7163.MCT-18-0234
Published: 03 December 2018
View article titled, Androgen Receptor Inhibitor Enhances the Antitumor Effect of PARP Inhibitor in Breast Cancer Cells by Modulating DNA Damage Response
Open the PDF for Androgen Receptor Inhibitor Enhances the Antitumor Effect of PARP Inhibitor in Breast Cancer Cells by Modulating DNA Damage Response in another window
Includes: Supplementary data
Journal Articles

AZD6738, A Novel Oral Inhibitor of ATR, Induces Synthetic Lethality with ATM Deficiency in Gastric Cancer Cells

Ahrum Min, Seock-Ah Im, Hyemin Jang, Seongyeong Kim, Miso Lee, Debora Keunyoung Kim, Yaewon Yang, Hee-Jun Kim, Kyung-Hun Lee, Jin Won Kim, Tae-Yong Kim, Do-Youn Oh, Jeff Brown, Alan Lau, Mark J. O'Connor, Yung-Jue Bang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (4): 566–577.
https://doi.org/10.1158/1535-7163.MCT-16-0378
Published: 02 April 2017
View article titled, AZD6738, A Novel Oral Inhibitor of ATR, Induces Synthetic Lethality with ATM Deficiency in Gastric Cancer Cells
Open the PDF for AZD6738, A Novel Oral Inhibitor of ATR, Induces Synthetic Lethality with ATM Deficiency in Gastric Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Abstract PL05-03: Exploiting cancer replication stress using pharmacological inhibitors of ATR and WEE1

Mark J. O'Connor
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): PL05-03.
https://doi.org/10.1158/1535-7163.TARG-15-PL05-03
Published: 01 December 2015
View article titled, Abstract PL05-03: Exploiting cancer replication stress using pharmacological inhibitors of ATR and WEE1
Journal Articles

RAD51C-Deficient Cancer Cells Are Highly Sensitive to the PARP Inhibitor Olaparib

Ahrum Min, Seock-Ah Im, Young-Kwang Yoon, Sang-Hyun Song, Hyun-Jin Nam, Hyung-Seok Hur, Hwang-Phill Kim, Kyung-Hun Lee, Sae-Won Han, Do-Youn Oh, Tae-You Kim, Mark J. O'Connor, Woo-Ho Kim, Yung-Jue Bang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (6): 865–877.
https://doi.org/10.1158/1535-7163.MCT-12-0950
Published: 09 June 2013
View article titled, RAD51C-Deficient Cancer Cells Are Highly Sensitive to the PARP Inhibitor Olaparib
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Includes: Supplementary data
Journal Articles

Inhibition of PARP-1 by Olaparib (AZD2281) Increases the Radiosensitivity of a Lung Tumor Xenograft

Joana M. Senra, Brian A. Telfer, Kim E. Cherry, Cian M. McCrudden, David G. Hirst, Mark J. O'Connor, Stephen R. Wedge, Ian J. Stratford
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (10): 1949–1958.
https://doi.org/10.1158/1535-7163.MCT-11-0278
Published: 09 October 2011
View article titled, Inhibition of PARP-1 by Olaparib (AZD2281) Increases the Radiosensitivity of a Lung Tumor Xenograft
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Includes: Supplementary data
Journal Articles

ATM Deficiency Sensitizes Mantle Cell Lymphoma Cells to Poly(ADP-Ribose) Polymerase-1 Inhibitors

Chris T. Williamson, Huong Muzik, Ali G. Turhan, Alberto Zamò, Mark J. O'Connor, D. Gwyn Bebb, Susan P. Lees-Miller
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (2): 347–357.
https://doi.org/10.1158/1535-7163.MCT-09-0872
Published: 09 February 2010
View article titled, ATM Deficiency Sensitizes Mantle Cell Lymphoma Cells to Poly(ADP-Ribose) Polymerase-1 Inhibitors
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Includes: Supplementary data
Journal Articles

Abstract A119: A proteomics‐based approach to identify biomarker profiles of homologous recombination deficiency (HRD) in breast cancer cell lines

John E. Prime, Louise Unwin, Jill Hunter, Richard Allum, Janice A. Nickson, Rachel Rowlinson, Sabrina Giavara, Carsten Lueck, Alan Lau, Mark J. O'Connor
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): A119.
https://doi.org/10.1158/1535-7163.TARG-09-A119
Published: 10 December 2009
View article titled, Abstract A119: A proteomics‐based approach to identify biomarker profiles of homologous recombination deficiency (HRD) in breast cancer cell lines
Journal Articles

Abstract C119: Identification of gene expression biomarkers that predict sensitivity to the PARP inhibitor olaparib

Alan Lau, Jonathan Dry, Chris Harbron, Charlotte Knights, Lucy Riches, Ramu Mangena, Tim Avis, Helen Brown, Sarah Runswick, Simon Dearden, Aisling O'Shaughnessy, Louise Unwin, John E. Prime, Darren Hodgson, James Carmichael, Mark J. O'Connor
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): C119.
https://doi.org/10.1158/1535-7163.TARG-09-C119
Published: 10 December 2009
View article titled, Abstract C119: Identification of gene expression biomarkers that predict sensitivity to the PARP inhibitor olaparib
Journal Articles

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

Sarah E. Golding, Elizabeth Rosenberg, Nicholas Valerie, Isa Hussaini, Mark Frigerio, Xiaoling F. Cockcroft, Wei Yee Chong, Marc Hummersone, Laurent Rigoreau, Keith A. Menear, Mark J. O'Connor, Lawrence F. Povirk, Timothy van Meter, Kristoffer Valerie
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (10): 2894–2902.
https://doi.org/10.1158/1535-7163.MCT-09-0519
Published: 12 October 2009
View article titled, Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
Open the PDF for Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion in another window
Includes: Supplementary data