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Marina Konopleva
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Journal Articles

Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic–Resistant AML and AML Stem Cells

Bing Z. Carter, Po Yee Mak, Wenjing Tao, Qi Zhang, Vivian Ruvolo, Vinitha M. Kuruvilla, Xiangmeng Wang, Duncan H. Mak, Venkata L. Battula, Marina Konopleva, Elias J. Jabbour, Paul E. Hughes, Xiaoyue Chen, Phuong K. Morrow, Michael Andreeff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (6): 879–889.
https://doi.org/10.1158/1535-7163.MCT-21-0690
Published: 01 June 2022
View articletitled, Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic–Resistant AML and AML Stem Cells
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Includes: Supplementary data
Journal Articles

Abstract CC09-01: Targeting BCL-XL/BCL-2 by PROTAC 753b effectively eliminates AML cells and enhances efficacy of chemotherapy by targeting senescent cells

Yannan Jia, Qi Zhang, Weiguo Zhang, Michael Andreeff, Nitin Jain, Helen Ma, Peiyi Zhang, Guangrong Zheng, Daohong Zhou, Marina Konopleva
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): CC09-01.
https://doi.org/10.1158/1535-7163.TARG-21-CC09-01
Published: 01 December 2021
View articletitled, Abstract CC09-01: Targeting BCL-XL/BCL-2 by PROTAC 753b effectively eliminates AML cells and enhances efficacy of chemotherapy by targeting senescent cells
Journal Articles

Selective Inhibition of the Second Bromodomain of BET Family Proteins Results in Robust Antitumor Activity in Preclinical Models of Acute Myeloid Leukemia

Lu Zhang, Tianyu Cai, Xiaoyu Lin, Xiaoli Huang, Mai H. Bui, Joshua P. Plotnik, Richard J. Bellin, Emily J. Faivre, Vinitha M. Kuruvilla, Lloyd T. Lam, Xin Lu, Zheng Zha, Weiguo Feng, Paul Hessler, Tamar Uziel, Qi Zhang, Antonio Cavazos, Lina Han, Debra C. Ferguson, Gaurav Mehta, Sriram S. Shanmugavelandy, Terrance J. Magoc, Jenny Rowe, Neal C. Goodwin, Kathleen A. Dorritie, Michael Boyiadzis, Daniel H. Albert, Keith F. McDaniel, Warren M. Kati, Marina Konopleva, Yu Shen
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (10): 1809–1819.
https://doi.org/10.1158/1535-7163.MCT-21-0029
Published: 01 October 2021
View articletitled, Selective Inhibition of the Second Bromodomain of BET Family Proteins Results in Robust Antitumor Activity in Preclinical Models of Acute Myeloid Leukemia
Open the PDF for Selective Inhibition of the Second Bromodomain of BET Family Proteins Results in Robust Antitumor Activity in Preclinical Models of Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-Time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia

Niki M. Zacharias, Natalia Baran, Sriram S. Shanmugavelandy, Jaehyuk Lee, Juliana Velez Lujan, Prasanta Dutta, Steven W. Millward, Tianyu Cai, Christopher G. Wood, David Piwnica-Worms, Marina Konopleva, Pratip K. Bhattacharya
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (11): 1937–1946.
https://doi.org/10.1158/1535-7163.MCT-18-0985
Published: 01 November 2019
View articletitled, Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-Time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia
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Includes: Supplementary data
Journal Articles

Antileukemia Effects of Notch-Mediated Inhibition of Oncogenic PLK1 in B-Cell Acute Lymphoblastic Leukemia

Sankaranarayanan Kannan, Marisa J.L. Aitken, Shelley M. Herbrich, Leonard S. Golfman, Mandy G. Hall, Duncan H. Mak, Jared K. Burks, Guangchun Song, Marina Konopleva, Charles G. Mullighan, Joya Chandra, Patrick A. Zweidler-McKay
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (9): 1615–1627.
https://doi.org/10.1158/1535-7163.MCT-18-0706
Published: 03 September 2019
View articletitled, Antileukemia Effects of Notch-Mediated Inhibition of Oncogenic PLK1 in B-Cell Acute Lymphoblastic Leukemia
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Includes: Supplementary data
Journal Articles

Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia

Wai-Kin Chan, Thomas D. Horvath, Lin Tan, Todd Link, Karine G. Harutyunyan, Michael A. Pontikos, Andriy Anishkin, Di Du, Leona A. Martin, Eric Yin, Susan B. Rempe, Sergei Sukharev, Marina Konopleva, John N. Weinstein, Philip L. Lorenzi
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2019) 18 (9): 1587–1592.
https://doi.org/10.1158/1535-7163.MCT-18-1329
Published: 03 September 2019
View articletitled, Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia
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Includes: Supplementary data
Journal Articles

mTORC1 Inhibition Induces Resistance to Methotrexate and 6-Mercaptopurine in Ph+ and Ph-like B-ALL

Thanh-Trang T. Vo, J. Scott Lee, Duc Nguyen, Brandon Lui, William Pandori, Andrew Khaw, Sharmila Mallya, Mengrou Lu, Markus Müschen, Marina Konopleva, David A. Fruman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (9): 1942–1953.
https://doi.org/10.1158/1535-7163.MCT-17-0024
Published: 04 September 2017
View articletitled, mTORC1 Inhibition Induces Resistance to Methotrexate and 6-Mercaptopurine in Ph+ and Ph-like B-ALL
Open the PDF for mTORC1 Inhibition Induces Resistance to Methotrexate and 6-Mercaptopurine in Ph+ and Ph-like B-ALL in another window
Includes: Supplementary data
Journal Articles

Abstract LB-A15: IACS-010759 is a novel inhibitor of oxidative phosphorylation that selectively targets AML cells by inducing a metabolic catastrophe

Jennifer R. Molina, Marina Protopopova, Madhavi Bandi, Jennifer Bardenhagen, Christopher Bristow, Maria Alimova, Christopher Carroll, Edward Chang, Ningping Feng, Jason Gay, Mary Geck Do, Jennifer Greer, Sha Huang, Yongying Jiang, Marina Konopleva, Polina Matre, Zhijun Kang, Gang Liu, Timothy McAfoos, Pietro Morlacchi, Melinda Smith, Sonal Sonal, Jay Theroff, Quanyun Xu, Giulio Draetta, Philip Jones, Carlo Toniatti, M. Emilia Di Francesco, Joseph R. Marszalek
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): LB-A15.
https://doi.org/10.1158/1535-7163.TARG-15-LB-A15
Published: 01 December 2015
View articletitled, Abstract LB-A15: IACS-010759 is a novel inhibitor of oxidative phosphorylation that selectively targets AML cells by inducing a metabolic catastrophe
Journal Articles

Evaluation of Apoptosis Induction by Concomitant Inhibition of MEK, mTOR, and Bcl-2 in Human Acute Myelogenous Leukemia Cells

Weiguo Zhang, Vivian R. Ruvolo, Chen Gao, Liran Zhou, William Bornmann, Twee Tsao, Wendy D. Schober, Paul Smith, Sylvie Guichard, Marina Konopleva, Michael Andreeff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2014) 13 (7): 1848–1859.
https://doi.org/10.1158/1535-7163.MCT-13-0576
Published: 06 July 2014
View articletitled, Evaluation of Apoptosis Induction by Concomitant Inhibition of MEK, mTOR, and Bcl-2 in Human Acute Myelogenous Leukemia Cells
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Includes: Supplementary data
Journal Articles

BH3 Profiling Discriminates Response to Cytarabine-Based Treatment of Acute Myelogenous Leukemia

William E. Pierceall, Steven M. Kornblau, Nicole E. Carlson, Xuelin Huang, Noel Blake, Ryan Lena, Michael Elashoff, Marina Konopleva, Michael H. Cardone, Michael Andreeff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (12): 2940–2949.
https://doi.org/10.1158/1535-7163.MCT-13-0692
Published: 05 December 2013
View articletitled, BH3 Profiling Discriminates Response to Cytarabine-Based Treatment of Acute Myelogenous Leukemia
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Includes: Supplementary data
Journal Articles

Triptolide induces cell death independent of cellular responses to imatinib in blast crisis chronic myelogenous leukemia cells including quiescent CD34+ primitive progenitor cells

Duncan H. Mak, Wendy D. Schober, Wenjing Chen, Marina Konopleva, Jorge Cortes, Hagop M. Kantarjian, Michael Andreeff, Bing Z. Carter
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (9): 2509–2516.
https://doi.org/10.1158/1535-7163.MCT-09-0386
Published: 17 September 2009
View articletitled, Triptolide induces cell death independent of cellular responses to imatinib in blast crisis chronic myelogenous leukemia cells including quiescent CD34+ primitive progenitor cells
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Journal Articles

Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells

Ismael Samudio, Svitlana Kurinna, Peter Ruvolo, Borys Korchin, Hagop Kantarjian, Miloslav Beran, Kenneth Dunner, Jr., Seiji Kondo, Michael Andreeff, Marina Konopleva
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (5): 1130–1139.
https://doi.org/10.1158/1535-7163.MCT-07-0553
Published: 15 May 2008
View articletitled, Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells
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Journal Articles

CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells

Linhua Jin, Yoko Tabe, Sergej Konoplev, Yuanyuan Xu, Clinton E. Leysath, Hongbo Lu, Shinya Kimura, Akimichi Ohsaka, Mary-Beth Rios, Leslie Calvert, Hagop Kantarjian, Michael Andreeff, Marina Konopleva
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (1): 48–58.
https://doi.org/10.1158/1535-7163.MCT-07-0042
Published: 17 January 2008
View articletitled, CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells
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Journal Articles

Phase I trial with a novel orally administered synthetic triterpenoid RTA 402 (CDDO-Me) in patients with solid tumors and lymphoid malignancies

David Hong, Razelle Kurzrock, Jeffrey Supko, Donald Lawrence, Jennifer Wheeler, Joseph Eder, Chaan Ng, James Mier, Marina Konopleva, Sergej Konoplev, Suhendan Ekmekcioglu, Michael Andreeff, Elizabeth Grimm, Donald Kufe, Colin Meyer, Geoffrey Shapiro, Bruce Dezube
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B82.
Published: 01 November 2007
View articletitled, Phase I trial with a novel orally administered synthetic triterpenoid RTA 402 (CDDO-Me) in patients with solid tumors and lymphoid malignancies
Journal Articles

Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias

Zhihong Zeng, Ismael J. Samudio, Mark Munsell, Jing An, Ziwei Huang, Elihu Estey, Michael Andreeff, Marina Konopleva
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2006) 5 (12): 3113–3121.
https://doi.org/10.1158/1535-7163.MCT-06-0228
Published: 15 December 2006
View articletitled, Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias
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Journal Articles

Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells

Marina Konopleva, Weiguo Zhang, Yue-Xi Shi, Teresa McQueen, Twee Tsao, Maen Abdelrahim, Mark F. Munsell, Mary Johansen, Dihua Yu, Timothy Madden, Stephen H. Safe, Mien-Chie Hung, Michael Andreeff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2006) 5 (2): 317–328.
https://doi.org/10.1158/1535-7163.MCT-05-0350
Published: 27 February 2006
View articletitled, Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells
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Journal Articles

Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure

Ismael Samudio, Marina Konopleva, Stephen Safe, Teresa McQueen, Michael Andreeff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2005) 4 (12): 1982–1992.
https://doi.org/10.1158/1535-7163.MCT-05-0247
Published: 22 December 2005
View articletitled, Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure
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Journal Articles

Peroxisome proliferator-activated receptor γ and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias

Marina Konopleva, Elena Elstner, Teresa J. McQueen, Twee Tsao, Andrey Sudarikov, Wei Hu, Wendy D. Schober, Rui-Yu Wang, David Chism, Steven M. Kornblau, Anas Younes, Steven J. Collins, H. Phillip Koeffler, Michael Andreeff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2004) 3 (10): 1249–1262.
https://doi.org/10.1158/1535-7163.1249.3.10
Published: 14 October 2004
View articletitled, Peroxisome proliferator-activated receptor γ and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias
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