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Lori Westendorf
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Journal Articles

SGN-B6A: A New Vedotin Antibody–Drug Conjugate Directed to Integrin Beta-6 for Multiple Carcinoma Indications

Robert P. Lyon, Mechthild Jonas, Christopher Frantz, Esther S. Trueblood, Roma Yumul, Lori Westendorf, Christopher J. Hale, Jackie L. Stilwell, Narayana Yeddula, Katie M. Snead, Vineet Kumar, Gabriela I. Patilea-Vrana, Kerry Klussman, Maureen C. Ryan
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12): 1444–1453.
https://doi.org/10.1158/1535-7163.MCT-22-0817
Published: 01 December 2023
View article titled, SGN-B6A: A New Vedotin Antibody–Drug Conjugate Directed to Integrin Beta-6 for Multiple Carcinoma Indications
Open the PDF for SGN-B6A: A New Vedotin Antibody–Drug Conjugate Directed to Integrin Beta-6 for Multiple Carcinoma Indications in another window
Includes: Supplementary data
Journal Articles

SGN-CD228A Is an Investigational CD228-Directed Antibody–Drug Conjugate with Potent Antitumor Activity across a Wide Spectrum of Preclinical Solid Tumor Models

Rebecca Mazahreh, Marsha L. Mason, John J. Gosink, Devra J. Olson, Robert Thurman, Christopher Hale, Lori Westendorf, Thomas A. Pires, Christopher I. Leiske, Markus Carlson, Liem T. Nguyen, Julia H. Cochran, Nicole M. Okeley, Roma Yumul, Steven Jin, Ivan J. Stone, Disha Sahetya, Albina Nesterova, Sean Allred, Kelly M. Hensley, Rachael Hu, Robert Lawrence, Timothy S. Lewis, Sharsti Sandall
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (4): 421–434.
https://doi.org/10.1158/1535-7163.MCT-22-0401
Published: 03 April 2023
View article titled, SGN-CD228A Is an Investigational CD228-Directed Antibody–Drug Conjugate with Potent Antitumor Activity across a Wide Spectrum of Preclinical Solid Tumor Models
Open the PDF for SGN-CD228A Is an Investigational CD228-Directed Antibody–Drug Conjugate with Potent Antitumor Activity across a Wide Spectrum of Preclinical Solid Tumor Models in another window
Includes: Supplementary data
Journal Articles

Mouse Strains Influence Clearance and Efficacy of Antibody and Antibody–Drug Conjugate Via Fc–FcγR Interaction

Fu Li, Michelle L. Ulrich, Vincent Feng-Sheng Shih, Julia H. Cochran, Joshua H. Hunter, Lori Westendorf, Jason Neale, Dennis R. Benjamin
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2019) 18 (4): 780–787.
https://doi.org/10.1158/1535-7163.MCT-18-0977
Published: 01 April 2019
View article titled, Mouse Strains Influence Clearance and Efficacy of Antibody and Antibody–Drug Conjugate Via Fc–FcγR Interaction
Open the PDF for Mouse Strains Influence Clearance and Efficacy of Antibody and Antibody–Drug Conjugate Via Fc–FcγR Interaction in another window
Includes: Supplementary data
Journal Articles

Characterization of SGN-CD123A, A Potent CD123-Directed Antibody–Drug Conjugate for Acute Myeloid Leukemia

Fu Li, May Kung Sutherland, Changpu Yu, Roland B. Walter, Lori Westendorf, John Valliere-Douglass, Lucy Pan, Ashley Cronkite, Django Sussman, Kerry Klussman, Michelle Ulrich, Martha E. Anderson, Ivan J. Stone, Weiping Zeng, Mechthild Jonas, Timothy S. Lewis, Maitrayee Goswami, Sa A. Wang, Peter D. Senter, Che-Leung Law, Eric J. Feldman, Dennis R. Benjamin
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2018) 17 (2): 554–564.
https://doi.org/10.1158/1535-7163.MCT-17-0742
Published: 01 February 2018
View article titled, Characterization of SGN-CD123A, A Potent CD123-Directed Antibody–Drug Conjugate for Acute Myeloid Leukemia
Open the PDF for Characterization of SGN-CD123A, A Potent CD123-Directed Antibody–Drug Conjugate for Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Tumor-Associated Macrophages Can Contribute to Antitumor Activity through FcγR-Mediated Processing of Antibody–Drug Conjugates

Fu Li, Michelle Ulrich, Mechthild Jonas, Ivan J. Stone, Germein Linares, Xinqun Zhang, Lori Westendorf, Dennis R. Benjamin, Che-Leung Law
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (7): 1347–1354.
https://doi.org/10.1158/1535-7163.MCT-17-0019
Published: 04 July 2017
View article titled, Tumor-Associated Macrophages Can Contribute to Antitumor Activity through FcγR-Mediated Processing of Antibody–Drug Conjugates
Open the PDF for Tumor-Associated Macrophages Can Contribute to Antitumor Activity through FcγR-Mediated Processing of Antibody–Drug Conjugates in another window
Includes: Supplementary data
Journal Articles

SGN–LIV1A: A Novel Antibody–Drug Conjugate Targeting LIV-1 for the Treatment of Metastatic Breast Cancer

Django Sussman, Leia M. Smith, Martha E. Anderson, Steve Duniho, Joshua H. Hunter, Heather Kostner, Jamie B. Miyamoto, Albina Nesterova, Lori Westendorf, Heather A. Van Epps, Nancy Whiting, Dennis R. Benjamin
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2014) 13 (12): 2991–3000.
https://doi.org/10.1158/1535-7163.MCT-13-0896
Published: 04 December 2014
View article titled, SGN–LIV1A: A Novel Antibody–Drug Conjugate Targeting LIV-1 for the Treatment of Metastatic Breast Cancer
Open the PDF for SGN–LIV1A: A Novel Antibody–Drug Conjugate Targeting LIV-1 for the Treatment of Metastatic Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract B204: Engineered cysteine antibodies: Improved antibody-drug conjugate vehicles.

Django Sussman, Lindsay Torrey, Lori Westendorf, Xinqun Zhang, Nicole M. Okeley, Stephen C. Alley, Robert Lyon, David Meyer, Jamie B. Miyamoto, Dennis R. Benjamin
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): B204.
https://doi.org/10.1158/1535-7163.TARG-11-B204
Published: 12 November 2011
View article titled, Abstract B204: Engineered cysteine antibodies: Improved antibody-drug conjugate vehicles.
Journal Articles

Engineered anti-CD70 antibody-drug conjugate with increased therapeutic index

Charlotte F. McDonagh, Kristine M. Kim, Eileen Turcott, Lindsay L. Brown, Lori Westendorf, Tiffany Feist, Django Sussman, Ivan Stone, Martha Anderson, Jamie Miyamoto, Robert Lyon, Stephen C. Alley, Hans-Peter Gerber, Paul J. Carter
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (9): 2913–2923.
https://doi.org/10.1158/1535-7163.MCT-08-0295
Published: 11 September 2008
View article titled, Engineered anti-CD70 antibody-drug conjugate with increased therapeutic index
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Includes: Supplementary data
Journal Articles

Anti-CD30 diabody-drug conjugates with potent antitumor activity

Kristine M. Kim, Charlotte F. McDonagh, Lori Westendorf, Lindsay L. Brown, Django Sussman, Tiffany Feist, Robert Lyon, Stephen C. Alley, Nicole M. Okeley, Xinqun Zhang, Melissa C. Thompson, Ivan Stone, Hans-Peter Gerber, Paul J. Carter
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (8): 2486–2497.
https://doi.org/10.1158/1535-7163.MCT-08-0388
Published: 21 August 2008
View article titled, Anti-CD30 diabody-drug conjugates with potent antitumor activity
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Includes: Supplementary data
Journal Articles

Humanized anti-CD19 auristatin antibody-drug conjugates display potent antitumor activity in preclinical models of B-cell malignancies

Hans-Peter Gerber, Carol Morris-Tilden, Ivan Stone, Mechthild Jonas, May Kung-Sutherland, Jamie Miyamoto, Lindsay Brown, Lori Westendorf, Damon Meyer, Django Sussman, Paul Carter, Che-Leung Law, Iqbal Grewal
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B60.
Published: 01 November 2007
View article titled, Humanized anti-CD19 auristatin antibody-drug conjugates display potent antitumor activity in preclinical models of B-cell malignancies