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Journal Articles

A Small-Molecule BCL6 Inhibitor as an Anti-Proliferative Agent for Diffuse Large B-Cell Lymphoma

Yajing Xing, Weikai Guo, Min Wu, Jiuqing Xie, Dongxia Huang, Pan Hu, Miaoran Zhou, Lin Zhang, Yadong Zhong, Mingyao Liu, Yihua Chen, Zhengfang Yi
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2025) 24 (1): 81–92.
https://doi.org/10.1158/1535-7163.MCT-23-0830
Published: 02 January 2025
View articletitled, A Small-Molecule BCL6 Inhibitor as an Anti-Proliferative Agent for Diffuse Large B-Cell Lymphoma
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Includes: Supplementary data
Journal Articles

PUMA/RIP3 Mediates Chemotherapy Response via Necroptosis and Local Immune Activation in Colorectal Cancer

Dongshi Chen, Kaylee Ermine, Yi-Jun Wang, Xiaojun Chen, Xinyan Lu, Peng Wang, Donna Beer-Stolz, Jian Yu, Lin Zhang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2024) 23 (3): 354–367.
https://doi.org/10.1158/1535-7163.MCT-23-0162
Published: 04 March 2024
View articletitled, PUMA/RIP3 Mediates Chemotherapy Response via Necroptosis and Local Immune Activation in Colorectal Cancer
Open the PDF for PUMA/RIP3 Mediates Chemotherapy Response via Necroptosis and Local Immune Activation in Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Shedding Light on the Dark Cancer Genomes: Long Noncoding RNAs as Novel Biomarkers and Potential Therapeutic Targets for Cancer

Lin Zhang, Dan Peng, Anil K. Sood, Chi V. Dang, Xiaomin Zhong
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (9): 1816–1823.
https://doi.org/10.1158/1535-7163.MCT-18-0124
Published: 04 September 2018
View articletitled, Shedding Light on the Dark Cancer Genomes: Long Noncoding RNAs as Novel Biomarkers and Potential Therapeutic Targets for Cancer
Open the PDF for Shedding Light on the Dark Cancer Genomes: Long Noncoding RNAs as Novel Biomarkers and Potential Therapeutic Targets for Cancer in another window
Journal Articles

FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors

Jingshan Tong, Shuai Tan, Zaneta Nikolovska-Coleska, Jian Yu, Fangdong Zou, Lin Zhang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (9): 1979–1988.
https://doi.org/10.1158/1535-7163.MCT-17-0032
Published: 04 September 2017
View articletitled, FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors
Open the PDF for FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors in another window
Includes: Supplementary data
Journal Articles

Aurora Kinase Inhibition Induces PUMA via NF-κB to Kill Colon Cancer Cells

Jing Sun, Kyle Knickelbein, Kan He, Dongshi Chen, Crissy Dudgeon, Yongqian Shu, Jian Yu, Lin Zhang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2014) 13 (5): 1298–1308.
https://doi.org/10.1158/1535-7163.MCT-13-0846
Published: 05 May 2014
View articletitled, Aurora Kinase Inhibition Induces PUMA via NF-κB to Kill Colon Cancer Cells
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Includes: Supplementary data
Journal Articles

Abstract B01: Nonsteroidal anti-inflammatory drugs selectively kill colon cancer cells through a synthetic lethal interaction

Brian Leibowitz, Mary P. Moyer, Jian Yu, Lin Zhang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (5_Supplement): B01.
https://doi.org/10.1158/1535-7163.PMS-B01
Published: 01 May 2014
View articletitled, Abstract B01: Nonsteroidal anti-inflammatory drugs selectively kill colon cancer cells through a synthetic lethal interaction
Journal Articles

Tunicamycin Potentiates Cisplatin Anticancer Efficacy through the DPAGT1/Akt/ABCG2 Pathway in Mouse Xenograft Models of Human Hepatocellular Carcinoma

Helei Hou, Hefen Sun, Ping Lu, Chao Ge, Lixing Zhang, Hong Li, Fangyu Zhao, Hua Tian, Lin Zhang, Taoyang Chen, Ming Yao, Jinjun Li
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (12): 2874–2884.
https://doi.org/10.1158/1535-7163.MCT-13-0201
Published: 05 December 2013
View articletitled, Tunicamycin Potentiates Cisplatin Anticancer Efficacy through the DPAGT1/Akt/ABCG2 Pathway in Mouse Xenograft Models of Human Hepatocellular Carcinoma
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Includes: Supplementary data
Journal Articles

Hsp90 Inhibitors Promote p53-Dependent Apoptosis through PUMA and Bax

Kan He, Xingnan Zheng, Lin Zhang, Jian Yu
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11): 2559–2568.
https://doi.org/10.1158/1535-7163.MCT-13-0284
Published: 06 November 2013
View articletitled, Hsp90 Inhibitors Promote p53-Dependent Apoptosis through PUMA and Bax
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Includes: Supplementary data
Journal Articles

Abstract C13: Patient derived gastric carcinoma xenograft (PDGCX) models largely maintain the histological and genetic diversities of corresponding patient tumor.

Xinying Su, Tianwei Zhang, Lin Zhang, Yanping Xu, Shuqiong Fan, Yuan Jie Liu, Meizhuo Zhang, Hao Chen, Liang Xie, Jingchuan Zhang, Xiaolu Yin, Yi Gu, Xingzhi Ni
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): C13.
https://doi.org/10.1158/1535-7163.TARG-13-C13
Published: 01 November 2013
View articletitled, Abstract C13: Patient derived gastric carcinoma xenograft (PDGCX) models largely maintain the histological and genetic diversities of corresponding patient tumor.
Journal Articles

Crizotinib Induces PUMA-Dependent Apoptosis in Colon Cancer Cells

Xingnan Zheng, Kan He, Lin Zhang, Jian Yu
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (5): 777–786.
https://doi.org/10.1158/1535-7163.MCT-12-1146
Published: 08 May 2013
View articletitled, Crizotinib Induces PUMA-Dependent Apoptosis in Colon Cancer Cells
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Includes: Supplementary data
Journal Articles

PUMA Induction by FoxO3a Mediates the Anticancer Activities of the Broad-Range Kinase Inhibitor UCN-01

Crissy Dudgeon, Peng Wang, Xiameng Sun, Rui Peng, Quanhong Sun, Jian Yu, Lin Zhang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (11): 2893–2902.
https://doi.org/10.1158/1535-7163.MCT-10-0635
Published: 09 November 2010
View articletitled, PUMA Induction by FoxO3a Mediates the Anticancer Activities of the Broad-Range Kinase Inhibitor UCN-01
Open the PDF for PUMA Induction by FoxO3a Mediates the Anticancer Activities of the Broad-Range Kinase Inhibitor UCN-01 in another window
Includes: Supplementary data
Journal Articles

A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells

Wen-Xing Ding, Hong-Min Ni, Xiaoyun Chen, Jian Yu, Lin Zhang, Xiao-Ming Yin
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (3): 1062–1069.
https://doi.org/10.1158/1535-7163.MCT-06-0541
Published: 15 March 2007
View articletitled, A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells
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Includes: Supplementary data
Journal Articles

Identification of new biomarkers for clinical trials of Hsp90 inhibitors

Hong Zhang, Daun Chung, Yong-Ching Yang, Laura Neely, Steven Tsurumoto, Junhua Fan, Lin Zhang, Marco Biamonte, John Brekken, Karen Lundgren, Francis Burrows
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2006) 5 (5): 1256–1264.
https://doi.org/10.1158/1535-7163.MCT-05-0537
Published: 26 May 2006
View articletitled, Identification of new biomarkers for clinical trials of Hsp90 inhibitors
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