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Journal Articles

Abstract A043: CDK8/19-regulated transcriptional reprogramming: a druggable driver of castration-resistant prostate cancer

Free
Jing Li, Thomas Hilimire, Yueying Liu, Lili Wang, Jiaxin Liang, Balazs Gyorffy, Vitali Sikitzhytski, Hao Ji, Li Zhang, Chen Cheng, Xiaokai Ding, Kendall Kerr, Charles Dowling, Gary Schools, Chang-Uk Lim, Eugenia Broude, George Wilding, Michael Lilly, Igor Roninson, Mengqian Chen
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): A043.
https://doi.org/10.1158/1535-7163.TARG-23-A043
Published: 01 December 2023
View articletitled, Abstract A043: CDK8/19-regulated transcriptional reprogramming: a druggable driver of castration-resistant prostate cancer
Journal Articles

HJM-561, a Potent, Selective, and Orally Bioavailable EGFR PROTAC that Overcomes Osimertinib-Resistant EGFR Triple Mutations

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Yong Du, Yongfeng Chen, Yuxia Wang, Jinju Chen, Xiaorong Lu, Li Zhang, Yan Li, Zhaofu Wang, Guozhong Ye, George Zhang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (7): 1060–1066.
https://doi.org/10.1158/1535-7163.MCT-21-0835
Published: 05 July 2022
View articletitled, HJM-561, a Potent, Selective, and Orally Bioavailable EGFR PROTAC that Overcomes Osimertinib-Resistant EGFR Triple Mutations
Open the PDF for HJM-561, a Potent, Selective, and Orally Bioavailable EGFR PROTAC that Overcomes Osimertinib-Resistant EGFR Triple Mutations in another window
Includes: Supplementary data
Journal Articles

Heme Sequestration as an Effective Strategy for the Suppression of Tumor Growth and Progression

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Tianyuan Wang, Adnin Ashrafi, Purna Chaitanya Konduri, Poorva Ghosh, Sanchareeka Dey, Parsa Modareszadeh, Narges Salamat, Parinaz Sadat Alemi, Eranda Berisha, Li Zhang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12): 2506–2518.
https://doi.org/10.1158/1535-7163.MCT-21-0033
Published: 03 December 2021
View articletitled, Heme Sequestration as an Effective Strategy for the Suppression of Tumor Growth and Progression
Open the PDF for Heme Sequestration as an Effective Strategy for the Suppression of Tumor Growth and Progression in another window
Includes: Supplementary data
Journal Articles

BRAFV600E Mutation in Cell-Free DNA, Rather than in Lesion Tissues, at Diagnosis Is An Independent Prognostic Factor in Children with Langerhans Cell Histiocytosis

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Chan-Juan Wang, Lei Cui, Hong-Hao Ma, Dong Wang, Li Zhang, Hong-Yun Lian, Wei-Jing Li, Qing Zhang, Tian-You Wang, Zhi-Gang Li, Rui Zhang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (7): 1316–1323.
https://doi.org/10.1158/1535-7163.MCT-20-1075
Published: 01 July 2021
View articletitled, BRAFV600E Mutation in Cell-Free DNA, Rather than in Lesion Tissues, at Diagnosis Is An Independent Prognostic Factor in Children with Langerhans Cell Histiocytosis
Open the PDF for BRAFV600E Mutation in Cell-Free DNA, Rather than in Lesion Tissues, at Diagnosis Is An Independent Prognostic Factor in Children with Langerhans Cell Histiocytosis in another window
Includes: Supplementary data
Journal Articles

Abstract C055: Novel imipridone ONC206 inhibits cell proliferation and induces apoptosis in uterine serous cancer through altering MAPK/AKT/AMPK signaling network and metabolic reprogramming

Free
Chi Lam Au Yeung, Wen Hu, Li Zhang, Sammy Ferri-Borgogno, Rohinton Tarapore, Karen H Lu, Samuel C Mok
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): C055.
https://doi.org/10.1158/1535-7163.TARG-19-C055
Published: 01 December 2019
View articletitled, Abstract C055: Novel imipridone ONC206 inhibits cell proliferation and induces apoptosis in uterine serous cancer through altering MAPK/AKT/AMPK signaling network and metabolic reprogramming
Journal Articles

AC0010, an Irreversible EGFR Inhibitor Selectively Targeting Mutated EGFR and Overcoming T790M-Induced Resistance in Animal Models and Lung Cancer Patients

Free
Xiao Xu, Long Mao, Wanhong Xu, Wei Tang, Xiaoying Zhang, Biao Xi, Rongda Xu, Xin Fang, Jia Liu, Ce Fang, Li Zhao, Xiaobo Wang, Ji Jiang, Pei Hu, Hongyun Zhao, Li Zhang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (11): 2586–2597.
https://doi.org/10.1158/1535-7163.MCT-16-0281
Published: 01 November 2016
View articletitled, AC0010, an Irreversible EGFR Inhibitor Selectively Targeting Mutated EGFR and Overcoming T790M-Induced Resistance in Animal Models and Lung Cancer Patients
Open the PDF for AC0010, an Irreversible EGFR Inhibitor Selectively Targeting Mutated EGFR and Overcoming T790M-Induced Resistance in Animal Models and Lung Cancer Patients in another window
Includes: Supplementary data
Journal Articles

ERBB3/HER2 Signaling Promotes Resistance to EGFR Blockade in Head and Neck and Colorectal Cancer Models

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Li Zhang, Carla Castanaro, Bo Luan, Katie Yang, Liangfen Fan, Jeanette L. Fairhurst, Ashique Rafique, Terra B. Potocky, Jing Shan, Frank J. Delfino, Ergang Shi, Tammy Huang, Joel H. Martin, Gang Chen, Douglas MacDonald, John S. Rudge, Gavin Thurston, Christopher Daly
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2014) 13 (5): 1345–1355.
https://doi.org/10.1158/1535-7163.MCT-13-1033
Published: 05 May 2014
View articletitled, ERBB3/HER2 Signaling Promotes Resistance to EGFR Blockade in Head and Neck and Colorectal Cancer Models
Open the PDF for ERBB3/HER2 Signaling Promotes Resistance to EGFR Blockade in Head and Neck and Colorectal Cancer Models in another window
Includes: Supplementary data
Journal Articles

Global Evaluation of Eph Receptors and Ephrins in Lung Adenocarcinomas Identifies EphA4 as an Inhibitor of Cell Migration and Invasion

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Pierre Saintigny, Shaohua Peng, Li Zhang, Banibrata Sen, Ignacio I. Wistuba, Scott M. Lippman, Luc Girard, John D. Minna, John V. Heymach, Faye M. Johnson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (9): 2021–2032.
https://doi.org/10.1158/1535-7163.MCT-12-0030
Published: 06 September 2012
View articletitled, Global Evaluation of Eph Receptors and Ephrins in Lung Adenocarcinomas Identifies EphA4 as an Inhibitor of Cell Migration and Invasion
Open the PDF for Global Evaluation of Eph Receptors and Ephrins in Lung Adenocarcinomas Identifies EphA4 as an Inhibitor of Cell Migration and Invasion in another window
Includes: Supplementary data
Journal Articles

Inhibition of STAT3 Signaling Pathway by Nitidine Chloride Suppressed the Angiogenesis and Growth of Human Gastric Cancer

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Jing Chen, Jieqiong Wang, Lei Lin, Lijun He, Yuanyuan Wu, Li Zhang, Zhengfang Yi, Yihua Chen, Xiufeng Pang, Mingyao Liu
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (2): 277–287.
https://doi.org/10.1158/1535-7163.MCT-11-0648
Published: 08 February 2012
View articletitled, Inhibition of STAT3 Signaling Pathway by Nitidine Chloride Suppressed the Angiogenesis and Growth of Human Gastric Cancer
Open the PDF for Inhibition of STAT3 Signaling Pathway by Nitidine Chloride Suppressed the Angiogenesis and Growth of Human Gastric Cancer in another window
Includes: Supplementary data
Journal Articles

MK-2206, a Novel Allosteric Inhibitor of Akt, Synergizes with Gefitinib against Malignant Glioma via Modulating Both Autophagy and Apoptosis

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Yan Cheng, Yi Zhang, Li Zhang, Xingcong Ren, Kathryn J. Huber-Keener, Xiaoyuan Liu, Lei Zhou, Jason Liao, Heike Keihack, Li Yan, Eric Rubin, Jin-Ming Yang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (1): 154–164.
https://doi.org/10.1158/1535-7163.MCT-11-0606
Published: 09 January 2012
View articletitled, MK-2206, a Novel Allosteric Inhibitor of Akt, Synergizes with Gefitinib against Malignant Glioma via Modulating Both Autophagy and Apoptosis
Open the PDF for MK-2206, a Novel Allosteric Inhibitor of Akt, Synergizes with Gefitinib against Malignant Glioma via Modulating Both Autophagy and Apoptosis in another window
Includes: Supplementary data
Journal Articles

Rapamycin Regulates Stearoyl CoA Desaturase 1 Expression in Breast Cancer

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David Luyimbazi, Argun Akcakanat, Priscilla F. McAuliffe, Li Zhang, Gopal Singh, Ana Maria Gonzalez-Angulo, Huiqin Chen, Kim-Anh Do, Yuhuan Zheng, Mien-Chie Hung, Gordon B. Mills, Funda Meric-Bernstam
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (10): 2770–2784.
https://doi.org/10.1158/1535-7163.MCT-09-0980
Published: 10 October 2010
View articletitled, Rapamycin Regulates Stearoyl CoA Desaturase 1 Expression in Breast Cancer
Open the PDF for Rapamycin Regulates Stearoyl CoA Desaturase 1 Expression in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

B cell translocation gene 1 contributes to antisense Bcl-2-mediated apoptosis in breast cancer cells

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Rita Nahta, Linda X.H. Yuan, Derek J. Fiterman, Li Zhang, W. Fraser Symmans, Naoto T. Ueno, Francisco J. Esteva
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2006) 5 (6): 1593–1601.
https://doi.org/10.1158/1535-7163.MCT-06-0133
Published: 03 July 2006
View articletitled, B cell translocation gene 1 contributes to antisense Bcl-2-mediated apoptosis in breast cancer cells
Open the PDF for B cell translocation gene 1 contributes to antisense Bcl-2-mediated apoptosis in breast cancer cells in another window