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Journal Articles

On-Target Pharmacodynamic Activity of the PI3K Inhibitor Copanlisib in Paired Biopsies from Patients with Malignant Lymphoma and Advanced Solid Tumors

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Franck Morschhauser, Jean-Pascal Machiels, Gilles Salles, Sylvie Rottey, Simon A.J. Rule, David Cunningham, Frederic Peyrade, Christophe Fruchart, Hendrik-Tobias Arkenau, Isabelle Genvresse, Li Liu, Karl Köchert, Kui Shen, Christoph Kneip, Carol E. Peña, Joachim Grevel, Jun Zhang, Galia Cisternas, Susanne Reschke, Camille Granvil, Ahmad Awada
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2020) 19 (2): 468–478.
https://doi.org/10.1158/1535-7163.MCT-19-0466
Published: 06 February 2020
View articletitled, On-Target Pharmacodynamic Activity of the PI3K Inhibitor Copanlisib in Paired Biopsies from Patients with Malignant Lymphoma and Advanced Solid Tumors
Open the PDF for On-Target Pharmacodynamic Activity of the PI3K Inhibitor Copanlisib in Paired Biopsies from Patients with Malignant Lymphoma and Advanced Solid Tumors in another window
Includes: Supplementary data
Journal Articles

MiR-196a Is Upregulated in Gastric Cancer and Promotes Cell Proliferation by Downregulating p27kip1

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Ming Sun, Xiang-hua Liu, Jin-hai Li, Jin-song Yang, Er-bao Zhang, Dan-dan Yin, Zhi-li Liu, Jing Zhou, Ying Ding, Su-qin Li, Zhao-xia Wang, Xiu-feng Cao, Wei De
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (4): 842–852.
https://doi.org/10.1158/1535-7163.MCT-11-1015
Published: 08 April 2012
View articletitled, MiR-196a Is Upregulated in Gastric Cancer and Promotes Cell Proliferation by Downregulating p27kip1
Open the PDF for MiR-196a Is Upregulated in Gastric Cancer and Promotes Cell Proliferation by Downregulating p27kip1 in another window
Includes: Supplementary data
Journal Articles

Combinations of BRAF, MEK, and PI3K/mTOR Inhibitors Overcome Acquired Resistance to the BRAF Inhibitor GSK2118436 Dabrafenib, Mediated by NRAS or MEK Mutations

Free
James G. Greger, Stephen D. Eastman, Vivian Zhang, Maureen R. Bleam, Ashley M. Hughes, Kimberly N. Smitheman, Scott H. Dickerson, Sylvie G. Laquerre, Li Liu, Tona M. Gilmer
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (4): 909–920.
https://doi.org/10.1158/1535-7163.MCT-11-0989
Published: 08 April 2012
View articletitled, Combinations of BRAF, MEK, and PI3K/mTOR Inhibitors Overcome Acquired Resistance to the BRAF Inhibitor GSK2118436 Dabrafenib, Mediated by NRAS or MEK Mutations
Open the PDF for Combinations of BRAF, MEK, and PI3K/mTOR Inhibitors Overcome Acquired Resistance to the BRAF Inhibitor GSK2118436 Dabrafenib, Mediated by NRAS or MEK Mutations in another window
Includes: Supplementary data
Journal Articles

Abstract B71: Acquired resistance to the BRAF inhibitor GSK2118436, mediated by NRAS or MEK mutation, can be overcome with combinations that inhibit BRAF and MEK, BRAF and PI3K/mTOR, or MEK and PI3K/mTOR.

Free
James G. Greger, Jr., Stephen D. Eastman, Vivian Zhang, Maureen R. Bleam, Ashley Hughes, Kimberly N. Smitheman, Sylvie Laquerre, Li Liu, Tona M. Gilmer
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): B71.
https://doi.org/10.1158/1535-7163.TARG-11-B71
Published: 12 November 2011
View articletitled, Abstract B71: Acquired resistance to the BRAF inhibitor GSK2118436, mediated by NRAS or MEK mutation, can be overcome with combinations that inhibit BRAF and MEK, BRAF and PI3K/mTOR, or MEK and PI3K/mTOR.
Journal Articles

Hypoxia Induces Genomic DNA Demethylation through the Activation of HIF-1α and Transcriptional Upregulation of MAT2A in Hepatoma Cells

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Quanyan Liu, Li Liu, Yuhong Zhao, Jin Zhang, Dongfeng Wang, Jiwei Chen, Yueming He, Jianguo Wu, Zhonglin Zhang, Zhisu Liu
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (6): 1113–1123.
https://doi.org/10.1158/1535-7163.MCT-10-1010
Published: 08 June 2011
View articletitled, Hypoxia Induces Genomic DNA Demethylation through the Activation of HIF-1α and Transcriptional Upregulation of MAT2A in Hepatoma Cells
Open the PDF for Hypoxia Induces Genomic DNA Demethylation through the Activation of HIF-1α and Transcriptional Upregulation of MAT2A in Hepatoma Cells in another window
Includes: Supplementary data
Journal Articles

Synergistic Effects of Foretinib with HER-Targeted Agents in MET and HER1- or HER2-Coactivated Tumor Cells

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Li Liu, Hong Shi, Yuan Liu, Amber Anderson, John Peterson, James Greger, Anne-Marie Martin, Tona M. Gilmer
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (3): 518–530.
https://doi.org/10.1158/1535-7163.MCT-10-0698
Published: 08 March 2011
View articletitled, Synergistic Effects of Foretinib with HER-Targeted Agents in MET and HER1- or HER2-Coactivated Tumor Cells
Open the PDF for Synergistic Effects of Foretinib with HER-Targeted Agents in MET and HER1- or HER2-Coactivated Tumor Cells in another window
Includes: Supplementary data
Journal Articles

Abstract A238: The effects of foretinib on MET phosphorylation, gene expression, cell proliferation and tumor growth in MET‐amplified tumor cells in vitro and in vivo

Free
Li Liu, Yuan Liu, Shi Hong, James Greger, Anne‐Marie Martin, Tona Gilmer
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): A238.
https://doi.org/10.1158/1535-7163.TARG-09-A238
Published: 10 December 2009
View articletitled, Abstract A238: The effects of foretinib on MET phosphorylation, gene expression, cell proliferation and tumor growth in MET‐amplified tumor cells in vitro and in vivo
Journal Articles

Abstract B79: Antitumor activity of lapatinib as a single agent and in combination with capecitabine in a HER2‐amplified human gastric tumor model

Free
Li Liu, Anna Avrutskaya, Beverly Godfrey, Carmella C. Britt, Alan Meshaw, Robert J. Mullin, Tona Gilmer
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): B79.
https://doi.org/10.1158/1535-7163.TARG-09-B79
Published: 10 December 2009
View articletitled, Abstract B79: Antitumor activity of lapatinib as a single agent and in combination with capecitabine in a HER2‐amplified human gastric tumor model