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Journal Articles

Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase

Gabrielle McDonald, Victor Chubukov, John Coco, Kevin Truskowski, Rohini Narayanaswamy, Sung Choe, Mya Steadman, Erin Artin, Anil K. Padyana, Lei Jin, Sebastien Ronseaux, Charles Locuson, Zi-Peng Fan, Tabea Erdmann, Alan Mann, Sebastian Hayes, Mark Fletcher, Kavitha Nellore, Siva Sanjeeva Rao, Hosahalli Subramanya, K. Satish Reddy, Sunil K. Panigrahi, Thomas Antony, Sreevalsam Gopinath, Zhihua Sui, Nelamangala Nagaraja, Lenny Dang, Georg Lenz, Jonathan Hurov, Scott A. Biller, Josh Murtie, Kevin M. Marks, Danielle B. Ulanet
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2020) 19 (12): 2502–2515.
https://doi.org/10.1158/1535-7163.MCT-20-0550
Published: 02 December 2020
View article titled, Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase
Open the PDF for Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase in another window
Includes: Supplementary data
Journal Articles

Inhibition of HSP90 by AUY922 Preferentially Kills Mutant KRAS Colon Cancer Cells by Activating Bim through ER Stress

Chun Yan Wang, Su Tang Guo, Jia Yu Wang, Fen Liu, Yuan Yuan Zhang, Hamed Yari, Xu Guang Yan, Lei Jin, Xu Dong Zhang, Chen Chen Jiang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (3): 448–459.
https://doi.org/10.1158/1535-7163.MCT-15-0778
Published: 06 March 2016
View article titled, Inhibition of HSP90 by AUY922 Preferentially Kills Mutant <em>KRAS</em> Colon Cancer Cells by Activating Bim through ER Stress
Open the PDF for Inhibition of HSP90 by AUY922 Preferentially Kills Mutant <em>KRAS</em> Colon Cancer Cells by Activating Bim through ER Stress in another window
Includes: Supplementary data
Journal Articles

Abstract B242: Adipocytes contribute to resistance of human melanoma cells to chemotherapy and targeted therapy.

Mengna Chi, Jiezhong Chen, Yan Ye, Hsin-Yi Tseng, Fritz Lai, Kwang Hong Tay, Lei Jin, Chen Chen Jiang, Xu Dong Zhang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): B242.
https://doi.org/10.1158/1535-7163.TARG-13-B242
Published: 01 November 2013
View article titled, Abstract B242: Adipocytes contribute to resistance of human melanoma cells to chemotherapy and targeted therapy.