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Laurence H. Hurley
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Journal Articles

Orally active α-tocopheryloxyacetic acid suppresses tumor growth and multiplicity of spontaneous murine breast cancer

Tobias Hahn, Karen Fried, Laurence H. Hurley, Emmanuel T. Akporiaye
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (6): 1570–1578.
https://doi.org/10.1158/1535-7163.MCT-08-1079
Published: 10 June 2009
View article titled, Orally active α-tocopheryloxyacetic acid suppresses tumor growth and multiplicity of spontaneous murine breast cancer
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Journal Articles

NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1

Thomas S. Dexheimer, Steven S. Carey, Song Zuohe, Vijay M. Gokhale, Xiaohui Hu, Lauren B. Murata, Estelle M. Maes, Andrzej Weichsel, Daekyu Sun, Emmanuelle J. Meuillet, William R. Montfort, Laurence H. Hurley
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (5): 1363–1377.
https://doi.org/10.1158/1535-7163.MCT-08-1093
Published: 13 May 2009
View article titled, NM23-H2 may play an indirect role in transcriptional activation of <em>c-myc</em> gene expression but does not cleave the nuclease hypersensitive element III<sub>1</sub>
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Journal Articles

UA62784, a novel inhibitor of centromere protein E kinesin-like protein

Meredith C. Henderson, Yeng-Jeng Y. Shaw, Hong Wang, Haiyong Han, Laurence H. Hurley, Gary Flynn, Robert T. Dorr, Daniel D. Von Hoff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (1): 36–44.
https://doi.org/10.1158/1535-7163.MCT-08-0789
Published: 12 January 2009
View article titled, UA62784, a novel inhibitor of centromere protein E kinesin-like protein
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Includes: Supplementary data
Journal Articles

Psorospermin structural requirements for P-glycoprotein resistance reversal

Steven S. Carey, Mary Gleason-Guzman, Vijay Gokhale, Laurence H. Hurley
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (11): 3617–3623.
https://doi.org/10.1158/1535-7163.MCT-08-0519
Published: 11 November 2008
View article titled, Psorospermin structural requirements for P-glycoprotein resistance reversal
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Journal Articles

The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex–interactive agents

Daekyu Sun, Wei-Jun Liu, Kexiao Guo, Jadrian J. Rusche, Scot Ebbinghaus, Vijay Gokhale, Laurence H. Hurley
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (4): 880–889.
https://doi.org/10.1158/1535-7163.MCT-07-2119
Published: 15 April 2008
View article titled, The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex–interactive agents
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Journal Articles

Identification of a novel inhibitor of urokinase-type plasminogen activator

Ming Zhu, Vijay M. Gokhale, Lajos Szabo, Ruben M. Munoz, Hyounggee Baek, Sridevi Bashyam, Laurence H. Hurley, Daniel D. Von Hoff, Haiyong Han
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (4): 1348–1356.
https://doi.org/10.1158/1535-7163.MCT-06-0520
Published: 12 April 2007
View article titled, Identification of a novel inhibitor of urokinase-type plasminogen activator
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Journal Articles

Comparing Aurora A and Aurora B as molecular targets for growth inhibition of pancreatic cancer cells

Steven L. Warner, Ruben M. Munoz, Phillip Stafford, Erich Koller, Laurence H. Hurley, Daniel D. Von Hoff, Haiyong Han
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2006) 5 (10): 2450–2458.
https://doi.org/10.1158/1535-7163.MCT-06-0202
Published: 13 October 2006
View article titled, Comparing Aurora A and Aurora B as molecular targets for growth inhibition of pancreatic cancer cells
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Journal Articles

Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach

Steven L. Warner, Sridevi Bashyam, Hariprasad Vankayalapati, David J. Bearss, Haiyong Han, Daniel D. Von Hoff, Laurence H. Hurley
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2006) 5 (7): 1764–1773.
https://doi.org/10.1158/1535-7163.MCT-05-0524
Published: 04 August 2006
View article titled, Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach
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Journal Articles

Determination of the importance of the stereochemistry of psorospermin in topoisomerase II–induced alkylation of DNA and in vitro and in vivo biological activity

Ingrid M. Fellows, Michael Schwaebe, Thomas S. Dexheimer, Hariprasad Vankayalapati, Mary Gleason-Guzman, Jeffrey P. Whitten, Laurence H. Hurley
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2005) 4 (11): 1729–1739.
https://doi.org/10.1158/1535-7163.MCT-05-0183
Published: 07 November 2005
View article titled, Determination of the importance of the stereochemistry of psorospermin in topoisomerase II–induced alkylation of DNA and <em>in vitro</em> and <em>in vivo</em> biological activity
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Journal Articles

Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma

Masood A. Shammas, Robert J. Shmookler Reis, Masaharu Akiyama, Hemanta Koley, Dharminder Chauhan, Teru Hideshima, Raj K. Goyal, Laurence H. Hurley, Kenneth C. Anderson, Nikhil C. Munshi
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2003) 2 (9): 825–833.
Published: 10 October 2003
View article titled, Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma
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Journal Articles

The Cationic Porphyrin TMPyP4 Down-Regulates c-MYC and Human Telomerase Reverse Transcriptase Expression and Inhibits Tumor Growth in Vivo

Cory L. Grand, Haiyong Han, Rubén M. Muñoz, Steve Weitman, Daniel D. Von Hoff, Laurence H. Hurley, David J. Bearss
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2002) 1 (8): 565–573.
Published: 01 June 2002
View article titled, The Cationic Porphyrin TMPyP4 Down-Regulates c-<em>MYC</em> and Human Telomerase Reverse Transcriptase Expression and Inhibits Tumor Growth <em>in Vivo</em>
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Journal Articles

Design and Synthesis of Fluoroquinophenoxazines That Interact with Human Telomeric G-Quadruplexes and Their Biological Effects

Wenhu Duan, Anupama Rangan, Hariprasad Vankayalapati, Mu-Yong Kim, Qingping Zeng, Daekyu Sun, Haiyong Han, Oleg Yu. Fedoroff, David Nishioka, Sun Young Rha, Elzbieta Izbicka, Daniel D. Von Hoff, Laurence H. Hurley
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2001) 1 (2): 103–120.
Published: 01 December 2001
View article titled, Design and Synthesis of Fluoroquinophenoxazines That Interact with Human Telomeric G-Quadruplexes and Their Biological Effects
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