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Kristoffer Valerie
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Journal Articles

Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice

Jeremy Karlin, Jasmine Allen, Syed F. Ahmad, Gareth Hughes, Victoria Sheridan, Rajesh Odedra, Paul Farrington, Elaine B. Cadogan, Lucy C. Riches, Antonio Garcia-Trinidad, Andrew G. Thomason, Bhavika Patel, Jennifer Vincent, Alan Lau, Kurt G. Pike, Thomas A. Hunt, Amrita Sule, Nicholas C.K. Valerie, Laura Biddlestone-Thorpe, Jenna Kahn, Jason M. Beckta, Nitai Mukhopadhyay, Bernard Barlaam, Sebastien L. Degorce, Jason Kettle, Nicola Colclough, Joanne Wilson, Aaron Smith, Ian P. Barrett, Li Zheng, Tianwei Zhang, Yingchun Wang, Kan Chen, Martin Pass, Stephen T. Durant, Kristoffer Valerie
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (8): 1637–1647.
https://doi.org/10.1158/1535-7163.MCT-17-0975
Published: 31 July 2018
View articletitled, Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice
Open the PDF for Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract A104: AZD1390, a potent and selective orally bioavailable blood-brain barrier-penetrant ATM inhibitor, radiosensitizes and improves survival of orthotopic glioma and metastatic brain tumor models

Steve T. Durant, Kurt G. Pike, Nicola Colclough, Lucy Riches, Antonio Garcia-Trinidad, Thomas Hunt, Stephanie Ling, Jonathan Stott, Ian Barrett, Li Zheng, Yingchun Wang, Kan Chen, Tianwei Zhang, Venkatesh Pilla Reddy, Andrew Sykes, Peter Johnstrom, Gemma Jones, Andrew Pierce, Jeremy Karlin, Jenna Kahn, Jasmine Allen, Kristoffer Valerie, Ruth Illingworth, Martin Pass
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): A104.
https://doi.org/10.1158/1535-7163.TARG-17-A104
Published: 01 January 2018
View articletitled, Abstract A104: AZD1390, a potent and selective orally bioavailable blood-brain barrier-penetrant ATM inhibitor, radiosensitizes and improves survival of orthotopic glioma and metastatic brain tumor models
Journal Articles

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

Sarah E. Golding, Elizabeth Rosenberg, Nicholas Valerie, Isa Hussaini, Mark Frigerio, Xiaoling F. Cockcroft, Wei Yee Chong, Marc Hummersone, Laurent Rigoreau, Keith A. Menear, Mark J. O'Connor, Lawrence F. Povirk, Timothy van Meter, Kristoffer Valerie
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (10): 2894–2902.
https://doi.org/10.1158/1535-7163.MCT-09-0519
Published: 12 October 2009
View articletitled, Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
Open the PDF for Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion in another window
Includes: Supplementary data
Journal Articles

Radiation-induced cell signaling: inside-out and outside-in

Kristoffer Valerie, Adly Yacoub, Michael P. Hagan, David T. Curiel, Paul B. Fisher, Steven Grant, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (3): 789–801.
https://doi.org/10.1158/1535-7163.MCT-06-0596
Published: 15 March 2007
View articletitled, Radiation-induced cell signaling: inside-out and outside-in
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Journal Articles

Radiosensitization of MDA-MB-231 breast tumor cells by adenovirus-mediated overexpression of a fragment of the XRCC4 protein

Kara R. Jones, David A. Gewirtz, Steven M. Yannone, Shaoming Zhou, David G. Schatz, Kristoffer Valerie, Lawrence F. Povirk
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2005) 4 (10): 1541–1547.
https://doi.org/10.1158/1535-7163.MCT-05-0193
Published: 14 October 2005
View articletitled, Radiosensitization of MDA-MB-231 breast tumor cells by adenovirus-mediated overexpression of a fragment of the XRCC4 protein
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Journal Articles

MDA-7 (Interleukin-24) Inhibits the Proliferation of Renal Carcinoma Cells and Interacts with Free Radicals to Promote Cell Death and Loss of Reproductive Capacity

Adly Yacoub, Clint Mitchell, Jessica Brannon, Elizabeth Rosenberg, Liang Qiao, Robert McKinstry, W. Marston Linehan, Zao-shong Su, Devanand Sarkar, Irina V. Lebedeva, Kristoffer Valerie, Rahul V. Gopalkrishnan, Steven Grant, Paul B. Fisher, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2003) 2 (7): 623–632.
Published: 25 July 2003
View articletitled, MDA-7 (Interleukin-24) Inhibits the Proliferation of Renal Carcinoma Cells and Interacts with Free Radicals to Promote Cell Death and Loss of Reproductive Capacity
Open the PDF for MDA-7 (Interleukin-24) Inhibits the Proliferation of Renal Carcinoma Cells and Interacts with Free Radicals to Promote Cell Death and Loss of Reproductive Capacity in another window