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Klara Totpal
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Journal Articles

IL-15/IL-15Rα-Fc-Fusion Protein XmAb24306 Potentiates Activity of CD3 Bispecific Antibodies through Enhancing T-Cell Expansion

Available to Purchase
Ji Li, Robyn Clark, Dionysos Slaga, Kendra Avery, Ke Liu, Suzanne Schubbert, Rajat Varma, Eugene Chiang, Klara Totpal, Matthew J. Bernett, Patrick G. Holder, Teemu T. Junttila
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2024) 23 (9): 1305–1316.
https://doi.org/10.1158/1535-7163.MCT-23-0910
Published: 04 September 2024
View articletitled, IL-15/IL-15Rα-Fc-Fusion Protein XmAb24306 Potentiates Activity of CD3 Bispecific Antibodies through Enhancing T-Cell Expansion
Open the PDF for IL-15/IL-15Rα-Fc-Fusion Protein XmAb24306 Potentiates Activity of CD3 Bispecific Antibodies through Enhancing T-Cell Expansion in another window
Includes: Supplementary data
Journal Articles

Novel Anti-LY6G6D/CD3 T-Cell–Dependent Bispecific Antibody for the Treatment of Colorectal Cancer

Open Access
Peiyin Wang, Liping L. Sun, Robyn Clark, Maria Hristopoulos, Cecilia P.C. Chiu, Michael Dillon, WeiYu Lin, Amy A. Lo, Sreedevi Chalsani, Meghna Das Thakur, Kristin M. Zimmerman Savill, Lionel Rougé, Patrick Lupardus, Robert Piskol, Bushra Husain, Diego Ellerman, Vittal Shivva, Steven R. Leong, Meric Ovacik, Klara Totpal, Yan Wu, Christoph Spiess, Genee Lee, Douglas D. Leipold, Andrew G. Polson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (6): 974–985.
https://doi.org/10.1158/1535-7163.MCT-21-0599
Published: 01 June 2022
View articletitled, Novel Anti-LY6G6D/CD3 T-Cell–Dependent Bispecific Antibody for the Treatment of Colorectal Cancer
Open the PDF for Novel Anti-LY6G6D/CD3 T-Cell–Dependent Bispecific Antibody for the Treatment of Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Anti-LYPD1/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Ovarian Cancer

Available to Purchase
Amy A. Lo, Jennifer Johnston, Ji Li, Danielle Mandikian, Maria Hristopoulos, Robyn Clark, Dorothee Nickles, Wei-Ching Liang, Kathy Hötzel, Debra Dunlap, Thinh Pham, Hao Cai, Meric Ovacik, Daniel Bravo-Perez, Elaine Mai, Dionysos Slaga, Diego Ellerman, James Ziai, Klara Totpal, Genee Lee, C. Andrew Boswell, Jian Payandeh, Yan Wu, Teemu T. Junttila
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (4): 716–725.
https://doi.org/10.1158/1535-7163.MCT-20-0490
Published: 01 April 2021
View articletitled, Anti-LYPD1/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Ovarian Cancer
Open the PDF for Anti-LYPD1/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

Relative Target Affinities of T-Cell–Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model

Free
Danielle Mandikian, Nene Takahashi, Amy A. Lo, Ji Li, Jeffrey Eastham-Anderson, Dionysos Slaga, Jason Ho, Maria Hristopoulos, Robyn Clark, Klara Totpal, Kedan Lin, Sean B. Joseph, Mark S. Dennis, Saileta Prabhu, Teemu T. Junttila, C. Andrew Boswell
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (4): 776–785.
https://doi.org/10.1158/1535-7163.MCT-17-0657
Published: 01 April 2018
View articletitled, Relative Target Affinities of T-Cell–Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model
Open the PDF for Relative Target Affinities of T-Cell–Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model in another window
Includes: Supplementary data
Journal Articles

Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake

Free
Yonglei Shang, Yifan Mao, Jennifer Batson, Suzie J. Scales, Gail Phillips, Mark R. Lackner, Klara Totpal, Simon Williams, Jihong Yang, Zhijun Tang, Zora Modrusan, Christine Tan, Wei-Ching Liang, Siao Ping Tsai, Alexander Vanderbilt, Kenji Kozuka, Klaus Hoeflich, Janet Tien, Sarajane Ross, Congfen Li, Sang Hoon Lee, An Song, Yan Wu, Jean-Philippe Stephan, Avi Ashkenazi, Jiping Zha
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (9): 2599–2608.
https://doi.org/10.1158/1535-7163.MCT-07-2401
Published: 11 September 2008
View articletitled, Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake
Open the PDF for Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake in another window
Includes: Supplementary data
Journal Articles

Activity of Apomab, a fully human agonistic DR5 monoclonal antibody, in models of non-Hodgkin’s lymphoma

Free
Dylan Daniel, Becky Yang, Klara Totpal, Klaus Wagner, Sharon Yee, Sarajane Ross, Avi Ashkenazi
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B32.
Published: 01 November 2007
View articletitled, Activity of Apomab, a fully human agonistic DR5 monoclonal antibody, in models of non-Hodgkin’s lymphoma