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Journal Articles

Abstract B112: SNAP23-dependent SNARE complex is a novel molecular target in AL Amyloidosis and Multiple Myeloma by blocking free light chain secretion and triggering a terminal unfolded protein response

Emre Karayol, Maria Moscvin, Tianzeng Chen, Peter G. Czarnecki, Annamaria Gulla, Kenneth C. Anderson, Giada Bianchi

Mol Cancer Ther (2023) 22 (12_Supplement): B112.

https://doi.org/10.1158/1535-7163.TARG-23-B112

Published: 01 December 2023

View article titled, Abstract B112: SNAP23-dependent SNARE complex is a novel molecular target in AL Amyloidosis and Multiple Myeloma by blocking free light chain secretion and triggering a terminal unfolded protein response

Journal Articles

The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission

Kenneth C. Anderson, Lewis C. Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A. Diaz, Raymond N. DuBois, Keith T. Flaherty, Philip D. Greenberg, Massimo Loda, Elaine R. Mardis, Elizabeth A. Platz, Michael N. Pollak, Robert D. Schreiber, Lillian L. Siu, Beverly A. Teicher

Mol Cancer Ther (2022) 21 (11): 1625–1631.

https://doi.org/10.1158/1535-7163.MCT-22-0655

Published: 03 November 2022

View article titled, The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission

Journal Articles

Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma

Nicola Amodio, Maria Angelica Stamato, Anna Maria Gullà, Eugenio Morelli, Enrica Romeo, Lavinia Raimondi, Maria Rita Pitari, Ida Ferrandino, Gabriella Misso, Michele Caraglia, Ida Perrotta, Antonino Neri, Mariateresa Fulciniti, Christian Rolfo, Kenneth C. Anderson, Nikhil C. Munshi, Pierosandro Tagliaferri, Pierfrancesco Tassone

Mol Cancer Ther (2016) 15 (6): 1364–1375.

https://doi.org/10.1158/1535-7163.MCT-15-0985

Published: 02 June 2016

View article titled, Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma

Includes: Supplementary data

Journal Articles

Delineating the mTOR Kinase Pathway Using a Dual TORC1/2 Inhibitor, AZD8055, in Multiple Myeloma

Diana Cirstea, Loredana Santo, Teru Hideshima, Homare Eda, Yuko Mishima, Neeharika Nemani, Anuj Mahindra, Andrew Yee, Gullu Gorgun, Yiguo Hu, Hiroto Ohguchi, Rikio Suzuki, Francesca Cottini, Sylvie M. Guichard, Kenneth C. Anderson, Noopur Raje

Mol Cancer Ther (2014) 13 (11): 2489–2500.

https://doi.org/10.1158/1535-7163.MCT-14-0147

Published: 03 November 2014

View article titled, Delineating the mTOR Kinase Pathway Using a Dual TORC1/2 Inhibitor, AZD8055, in Multiple Myeloma

Includes: Supplementary data

Journal Articles

Adenosine A2A and Beta-2 Adrenergic Receptor Agonists: Novel Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening

Richard J. Rickles, Winnie F. Tam, Thomas P. Giordano, III, Laura T. Pierce, Melissa Farwell, Douglas W. McMillin, Antoaneta Necheva, David Crowe, Mei Chen, William Avery, Vikram Kansra, Steffan T. Nawrocki, Jennifer S. Carew, Francis J. Giles, Constantine S. Mitsiades, Alexis A. Borisy, Kenneth C. Anderson, Margaret S. Lee

Mol Cancer Ther (2012) 11 (7): 1432–1442.

https://doi.org/10.1158/1535-7163.MCT-11-0925

Published: 05 July 2012

View article titled, Adenosine A2A and Beta-2 Adrenergic Receptor Agonists: Novel Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening

Includes: Supplementary data

Journal Articles

Molecular and Cellular Effects of NEDD8-Activating Enzyme Inhibition in Myeloma

Douglas W. McMillin, Hannah M. Jacobs, Jake E. Delmore, Leutz Buon, Zachary R. Hunter, Val Monrose, Jie Yu, Peter G. Smith, Paul G. Richardson, Kenneth C. Anderson, Steven P. Treon, Andrew L. Kung, Constantine S. Mitsiades

Mol Cancer Ther (2012) 11 (4): 942–951.

https://doi.org/10.1158/1535-7163.MCT-11-0563

Published: 08 April 2012

View article titled, Molecular and Cellular Effects of NEDD8-Activating Enzyme Inhibition in Myeloma

Includes: Supplementary data

Journal Articles

Mechanism of Action of Proteasome Inhibitors and Deacetylase Inhibitors and the Biological Basis of Synergy in Multiple Myeloma

Teru Hideshima, Paul G. Richardson, Kenneth C. Anderson

Mol Cancer Ther (2011) 10 (11): 2034–2042.

https://doi.org/10.1158/1535-7163.MCT-11-0433

Published: 08 November 2011

View article titled, Mechanism of Action of Proteasome Inhibitors and Deacetylase Inhibitors and the Biological Basis of Synergy in Multiple Myeloma

Journal Articles

Dual Inhibition of Akt/Mammalian Target of Rapamycin Pathway by Nanoparticle Albumin-Bound–Rapamycin and Perifosine Induces Antitumor Activity in Multiple Myeloma

Diana Cirstea, Teru Hideshima, Scott Rodig, Loredana Santo, Samantha Pozzi, Sonia Vallet, Hiroshi Ikeda, Giulia Perrone, Gullu Gorgun, Kishan Patel, Neil Desai, Peter Sportelli, Shweta Kapoor, Shireen Vali, Siddhartha Mukherjee, Nikhil C. Munshi, Kenneth C. Anderson, Noopur Raje

Mol Cancer Ther (2010) 9 (4): 963–975.

https://doi.org/10.1158/1535-7163.MCT-09-0763

Published: 07 April 2010

View article titled, Dual Inhibition of Akt/Mammalian Target of Rapamycin Pathway by Nanoparticle Albumin-Bound–Rapamycin and Perifosine Induces Antitumor Activity in Multiple Myeloma

Includes: Supplementary data

Journal Articles

Abstract C94: Deubiquitylases as novel anticancer targets: Discovery and development of novel USP7 inhibitors

KG Suresh Kumar, Ping Cao, Seth J. Goldenberg, Craig A. Leach, Jeffrey L. McDermott, Matthew P. Kodrasov, Dharminder Chauhan, Ze Tian, Kenneth C. Anderson, Michael R. Mattern, Benjamin Nicholson

Mol Cancer Ther (2009) 8 (12_Supplement): C94.

https://doi.org/10.1158/1535-7163.TARG-09-C94

Published: 10 December 2009

View article titled, Abstract C94: Deubiquitylases as novel anticancer targets: Discovery and development of novel USP7 inhibitors

Journal Articles

Abstract A237: The transcriptional signature of kinases inhibited by the multitargeted kinase inhibitor AS703569 is associated with inferior clinical outcome in multiple myeloma (MM), with promising anti‐MM activity of AS703569 demonstrated in preclinical studies in vitro and in vivo

Jake Delmore, David N. Cervi, Douglas W. McMillin, Efstathios Kastritis, Jana Jakubikova, Steffen Klippel, Joseph M. Negri, Buon Leutz, Jacob Laubach, Luca Rastelli, Ann Clark, Samantha Sarno, Paul G. Richardson, Kenneth C. Anderson, Mitsiades Constantine

Mol Cancer Ther (2009) 8 (12_Supplement): A237.

https://doi.org/10.1158/1535-7163.TARG-09-A237

Published: 10 December 2009

View article titled, Abstract A237: The transcriptional signature of kinases inhibited by the multitargeted kinase inhibitor AS703569 is associated with inferior clinical outcome in multiple myeloma (MM), with promising anti‐MM activity of AS703569 demonstrated in preclinical studies in vitro and in vivo

Journal Articles

Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo

Renate Burger, Steven Le Gouill, Yu-Tzu Tai, Reshma Shringarpure, Pierfrancesco Tassone, Paola Neri, Klaus Podar, Laurence Catley, Teru Hideshima, Dharminder Chauhan, Eian Caulder, Claire L. Neilan, Kris Vaddi, Jun Li, Martin Gramatzki, Jordan S. Fridman, Kenneth C. Anderson

Mol Cancer Ther (2009) 8 (1): 26–35.

https://doi.org/10.1158/1535-7163.MCT-08-0149

Published: 12 January 2009

View article titled, Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo

Journal Articles

5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells

Tanyel Kiziltepe, Teru Hideshima, Laurence Catley, Noopur Raje, Hiroshi Yasui, Norihiko Shiraishi, Yutaka Okawa, Hiroshi Ikeda, Sonia Vallet, Samantha Pozzi, Kenji Ishitsuka, Enrique M. Ocio, Dharminder Chauhan, Kenneth C. Anderson

Mol Cancer Ther (2007) 6 (6): 1718–1727.

https://doi.org/10.1158/1535-7163.MCT-07-0010

Published: 15 June 2007

View article titled, 5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells

Journal Articles

Proteasome inhibitor therapy in multiple myeloma

Dharminder Chauhan, Teru Hideshima, Constantine Mitsiades, Paul Richardson, Kenneth C. Anderson

Mol Cancer Ther (2005) 4 (4): 686–692.

https://doi.org/10.1158/1535-7163.MCT-04-0338

Published: 12 April 2005

View article titled, Proteasome inhibitor therapy in multiple myeloma

Journal Articles

Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma

Masood A. Shammas, Robert J. Shmookler Reis, Masaharu Akiyama, Hemanta Koley, Dharminder Chauhan, Teru Hideshima, Raj K. Goyal, Laurence H. Hurley, Kenneth C. Anderson, Nikhil C. Munshi

Mol Cancer Ther (2003) 2 (9): 825–833.

Published: 10 October 2003

View article titled, Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma

Journal Articles

Synopsis of a Research Roundtable Presented on Cell Signaling in Myeloma: Regulation of Growth and Apoptosis—Opportunities for New Drug Discovery

Kenneth C. Anderson, William S. Dalton

Mol Cancer Ther (2002) 1 (14): 1361–1365.

Published: 01 December 2002

View article titled, Synopsis of a Research Roundtable Presented on Cell Signaling in Myeloma: Regulation of Growth and Apoptosis—Opportunities for New Drug Discovery

Journal Articles

Arsenic Trioxide Inhibits Growth of Human Multiple Myeloma Cells in the Bone Marrow Microenvironment

Toshiaki Hayashi, Teru Hideshima, Masaharu Akiyama, Paul Richardson, Robert L. Schlossman, Dharminder Chauhan, Nikhil C. Munshi, Samuel Waxman, Kenneth C. Anderson

Mol Cancer Ther (2002) 1 (10): 851–860.

Published: 01 August 2002

View article titled, Arsenic Trioxide Inhibits Growth of Human Multiple Myeloma Cells in the Bone Marrow Microenvironment

Journal Articles

The Biological Sequelae of Stromal Cell-derived Factor-1α in Multiple Myeloma

Teru Hideshima, Dharminder Chauhan, Toshiaki Hayashi, Klaus Podar, Masaharu Akiyama, Deepak Gupta, Paul Richardson, Nikhil Munshi, Kenneth C. Anderson

Mol Cancer Ther (2002) 1 (7): 539–544.

Published: 01 May 2002

View article titled, The Biological Sequelae of Stromal Cell-derived Factor-1α in Multiple Myeloma

NARROW

Abstract B112: SNAP23-dependent SNARE complex is a novel molecular target in AL Amyloidosis and Multiple Myeloma by blocking free light chain secretion and triggering a terminal unfolded protein response

The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission

Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma

Delineating the mTOR Kinase Pathway Using a Dual TORC1/2 Inhibitor, AZD8055, in Multiple Myeloma

Adenosine A2A and Beta-2 Adrenergic Receptor Agonists: Novel Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening

Molecular and Cellular Effects of NEDD8-Activating Enzyme Inhibition in Myeloma

Mechanism of Action of Proteasome Inhibitors and Deacetylase Inhibitors and the Biological Basis of Synergy in Multiple Myeloma

Dual Inhibition of Akt/Mammalian Target of Rapamycin Pathway by Nanoparticle Albumin-Bound–Rapamycin and Perifosine Induces Antitumor Activity in Multiple Myeloma

Abstract C94: Deubiquitylases as novel anticancer targets: Discovery and development of novel USP7 inhibitors

Abstract A237: The transcriptional signature of kinases inhibited by the multitargeted kinase inhibitor AS703569 is associated with inferior clinical outcome in multiple myeloma (MM), with promising anti‐MM activity of AS703569 demonstrated in preclinical studies in vitro and in vivo

Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo

5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells

Proteasome inhibitor therapy in multiple myeloma

Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma

Synopsis of a Research Roundtable Presented on Cell Signaling in Myeloma: Regulation of Growth and Apoptosis—Opportunities for New Drug Discovery

Arsenic Trioxide Inhibits Growth of Human Multiple Myeloma Cells in the Bone Marrow Microenvironment

The Biological Sequelae of Stromal Cell-derived Factor-1α in Multiple Myeloma

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