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Journal Articles

Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors

Free
Laetitia Marzi, Keli Agama, Junko Murai, Simone Difilippantonio, Amy James, Cody J. Peer, William D. Figg, Daniel Beck, Mohamed S.A. Elsayed, Mark Cushman, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (8): 1694–1704.
https://doi.org/10.1158/1535-7163.MCT-18-0028
Published: 31 July 2018
View article titled, Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors
Open the PDF for Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors in another window
Includes: Supplementary data
Journal Articles

Abstract A182: Targeting the topoisomerase I enzyme in cancer cells with acquired resistance to SN-38

Free
Jan Stenvang, Niels Frank Jensen, Haatisha Jandu, Steen Knudsen, Keli Agama, Thomas Jensen, Anker Hansen, Peter Buhl Jensen, Yves Pommier, Mark Cushman, Nils Brünner
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): A182.
https://doi.org/10.1158/1535-7163.TARG-15-A182
Published: 01 December 2015
View article titled, Abstract A182: Targeting the topoisomerase I enzyme in cancer cells with acquired resistance to SN-38
Journal Articles

Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors

Free
Yeonee Seol, Hongliang Zhang, Keli Agama, Nicholas Lorence, Yves Pommier, Keir C. Neuman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (11): 2552–2559.
https://doi.org/10.1158/1535-7163.MCT-15-0454
Published: 03 November 2015
View article titled, Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors
Open the PDF for Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors in another window
Includes: Supplementary data
Journal Articles

Abstract A46: A novel immunoassay (ELISA) for quantitative gamma-H2AX detection and pharmacodynamic monitoring of DNA damage induced by chemotherapeutic agents and PARP inhibitors.

Free
Jay Ji, Yiping Zhang, Robert Kinders, Christophe Redon, Stephanie Solier, Keli Agama, Yves Pommier, William Bonner, Melinda Hollingshead, Larry Rubinstein, Alice Chen, Shivaani Kummar, Ralph E. Parchment, Joseph E. Tomaszewski, James H. Doroshow
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): A46.
https://doi.org/10.1158/1535-7163.TARG-11-A46
Published: 12 November 2011
View article titled, Abstract A46: A novel immunoassay (ELISA) for quantitative gamma-H2AX detection and pharmacodynamic monitoring of DNA damage induced by chemotherapeutic agents and PARP inhibitors.
Journal Articles

Abstract C224: A novel validated quantitative pharmacodynamic topoisomerase I covalent‐complex immunoassay

Free
Thomas D. Pfister, Sonny A. Khin, Keli Agama, Melinda Hollingshead, Dhriti Sooryakumar, Yves Pommier, Ralph E. Parchment, Joseph E. Tomaszewski, James H. Doroshow, Robert J. Kinders
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): C224.
https://doi.org/10.1158/1535-7163.TARG-09-C224
Published: 10 December 2009
View article titled, Abstract C224: A novel validated quantitative pharmacodynamic topoisomerase I covalent‐complex immunoassay
Journal Articles

Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity

Free
Thomas D. Pfister, William C. Reinhold, Keli Agama, Shalu Gupta, Sonny A. Khin, Robert J. Kinders, Ralph E. Parchment, Joseph E. Tomaszewski, James H. Doroshow, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (7): 1878–1884.
https://doi.org/10.1158/1535-7163.MCT-09-0016
Published: 14 July 2009
View article titled, Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity
Open the PDF for Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity in another window
Includes: Supplementary data
Journal Articles

Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters

Free
Kazutaka Takagi, Thomas S. Dexheimer, Christophe Redon, Olivier Sordet, Keli Agama, Gilbert Lavielle, Alain Pierré, Susan E. Bates, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (12): 3229–3238.
https://doi.org/10.1158/1535-7163.MCT-07-0441
Published: 18 December 2007
View article titled, Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters
Open the PDF for Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters in another window
Journal Articles

Batracylin, 8-aminoisoindolo [1,2-b]quinazolin-10(12H)-one (NSC 320846), a dual inhibitor of DNA topoisomerases I and II: molecular mechanisms and γ-H2AX as a biomarker of DNA damage.

Free
V. Ashutosh Rao, Keli Agama, Susan Holbeck, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): A172.
Published: 01 November 2007
View article titled, Batracylin, 8-aminoisoindolo [1,2-b]quinazolin-10(12H)-one (NSC 320846), a dual inhibitor of DNA topoisomerases I and II: molecular mechanisms and γ-H2AX as a biomarker of DNA damage.
Journal Articles

Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance

Free
Yves Pommier, Smitha Antony, Keli Agama, Ze-Hong Miao, Kazutaka Takagi, Susan Bates, Mollie Wright, Anna Robbles, Lyuba Varticovski, Muthukaman Nagarajan, Andrew Morrell, Mark Cushman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): C219.
Published: 01 November 2007
View article titled, Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance
Journal Articles

Novel E-ring camptothecin-keto-analogs (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters.

Free
Kazutaka Takagi, Thomas Dexheimer, Christophe Redon, Olivier Sordet, Keli Agama, Gilbert Lavielle, Alain Pierre, Robert Robey, Susan Bates, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): A268.
Published: 01 November 2007
View article titled, Novel E-ring camptothecin-keto-analogs (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters.