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Kazuto Nishio
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Journal Articles

Characterization of EGFR T790M, L792F, and C797S Mutations as Mechanisms of Acquired Resistance to Afatinib in Lung Cancer

Yoshihisa Kobayashi, Koichi Azuma, Hiroki Nagai, Young Hak Kim, Yosuke Togashi, Yuichi Sesumi, Masato Chiba, Masaki Shimoji, Katsuaki Sato, Kenji Tomizawa, Toshiki Takemoto, Kazuto Nishio, Tetsuya Mitsudomi
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (2): 357–364.
https://doi.org/10.1158/1535-7163.MCT-16-0407
Published: 02 February 2017
View article titled, Characterization of EGFR T790M, L792F, and C797S Mutations as Mechanisms of Acquired Resistance to Afatinib in Lung Cancer
Open the PDF for Characterization of EGFR T790M, L792F, and C797S Mutations as Mechanisms of Acquired Resistance to Afatinib in Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Afatinib against Esophageal or Head-and-Neck Squamous Cell Carcinoma: Significance of Activating Oncogenic HER4 Mutations in HNSCC

Yu Nakamura, Yosuke Togashi, Hirokazu Nakahara, Shuta Tomida, Eri Banno, Masato Terashima, Hidetoshi Hayashi, Marco A. de Velasco, Kazuko Sakai, Yoshihiko Fujita, Takatsugu Okegawa, Kikuo Nutahara, Suguru Hamada, Kazuto Nishio
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (8): 1988–1997.
https://doi.org/10.1158/1535-7163.MCT-15-0737
Published: 03 August 2016
View article titled, Afatinib against Esophageal or Head-and-Neck Squamous Cell Carcinoma: Significance of Activating Oncogenic <em>HER4</em> Mutations in HNSCC
Open the PDF for Afatinib against Esophageal or Head-and-Neck Squamous Cell Carcinoma: Significance of Activating Oncogenic <em>HER4</em> Mutations in HNSCC in another window
Includes: Supplementary data
Journal Articles

MEK Inhibitor for Gastric Cancer with MEK1 Gene Mutations

Shunsuke Sogabe, Yosuke Togashi, Hiroaki Kato, Akihiro Kogita, Takuro Mizukami, Yoichi Sakamoto, Eri Banno, Masato Terashima, Hidetoshi Hayashi, Marco A. de Velasco, Kazuko Sakai, Yoshihiko Fujita, Shuta Tomida, Takushi Yasuda, Yoshifumi Takeyama, Kiyotaka Okuno, Kazuto Nishio
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2014) 13 (12): 3098–3106.
https://doi.org/10.1158/1535-7163.MCT-14-0429
Published: 04 December 2014
View article titled, MEK Inhibitor for Gastric Cancer with <em>MEK1</em> Gene Mutations
Open the PDF for MEK Inhibitor for Gastric Cancer with <em>MEK1</em> Gene Mutations in another window
Includes: Supplementary data
Journal Articles

The Novel VEGF Receptor/MET–Targeted Kinase Inhibitor TAS-115 Has Marked In Vivo Antitumor Properties and a Favorable Tolerability Profile

Hidenori Fujita, Kazutaka Miyadera, Masanori Kato, Yayoi Fujioka, Hiroaki Ochiiwa, Jinhong Huang, Kimihiro Ito, Yoshimi Aoyagi, Toru Takenaka, Takamasa Suzuki, Satoko Ito, Akihiro Hashimoto, Takashi Suefuji, Kosuke Egami, Hideki Kazuno, Yoshimitsu Suda, Kazuto Nishio, Kazuhiko Yonekura
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (12): 2685–2696.
https://doi.org/10.1158/1535-7163.MCT-13-0459
Published: 05 December 2013
View article titled, The Novel VEGF Receptor/MET–Targeted Kinase Inhibitor TAS-115 Has Marked <em>In Vivo</em> Antitumor Properties and a Favorable Tolerability Profile
Open the PDF for The Novel VEGF Receptor/MET–Targeted Kinase Inhibitor TAS-115 Has Marked <em>In Vivo</em> Antitumor Properties and a Favorable Tolerability Profile in another window
Includes: Supplementary data
Journal Articles

Abstract A241: Differential roles of STAT3 depending on the mechanism of STAT3 activation in gastric cancer cells.

Wataru Okamoto, Isamu Okamoto, Katsuya Tuchihara, Kazuyoshi Yanagihara, Kazuto Nishio, Kazuhiko Nakagawa
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): A241.
https://doi.org/10.1158/1535-7163.TARG-13-A241
Published: 01 November 2013
View article titled, Abstract A241: Differential roles of STAT3 depending on the mechanism of STAT3 activation in gastric cancer cells.
Journal Articles

Antitumor Action of the MET Tyrosine Kinase Inhibitor Crizotinib (PF-02341066) in Gastric Cancer Positive for MET Amplification

Wataru Okamoto, Isamu Okamoto, Tokuzo Arao, Kiyoko Kuwata, Erina Hatashita, Haruka Yamaguchi, Kazuko Sakai, Kazuyoshi Yanagihara, Kazuto Nishio, Kazuhiko Nakagawa
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (7): 1557–1564.
https://doi.org/10.1158/1535-7163.MCT-11-0934
Published: 05 July 2012
View article titled, Antitumor Action of the MET Tyrosine Kinase Inhibitor Crizotinib (PF-02341066) in Gastric Cancer Positive for <em>MET</em> Amplification
Open the PDF for Antitumor Action of the MET Tyrosine Kinase Inhibitor Crizotinib (PF-02341066) in Gastric Cancer Positive for <em>MET</em> Amplification in another window
Includes: Supplementary data
Journal Articles

Sorafenib Inhibits the Hepatocyte Growth Factor–Mediated Epithelial Mesenchymal Transition in Hepatocellular Carcinoma

Tomoyuki Nagai, Tokuzo Arao, Kazuyuki Furuta, Kazuko Sakai, Kanae Kudo, Hiroyasu Kaneda, Daisuke Tamura, Keiichi Aomatsu, Hideharu Kimura, Yoshihiko Fujita, Kazuko Matsumoto, Nagahiro Saijo, Masatoshi Kudo, Kazuto Nishio
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (1): 169–177.
https://doi.org/10.1158/1535-7163.MCT-10-0544
Published: 10 January 2011
View article titled, Sorafenib Inhibits the Hepatocyte Growth Factor–Mediated Epithelial Mesenchymal Transition in Hepatocellular Carcinoma
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Includes: Supplementary data
Journal Articles

TAK-701, a Humanized Monoclonal Antibody to Hepatocyte Growth Factor, Reverses Gefitinib Resistance Induced by Tumor-Derived HGF in Non–Small Cell Lung Cancer with an EGFR Mutation

Wataru Okamoto, Isamu Okamoto, Kaoru Tanaka, Erina Hatashita, Yuki Yamada, Kiyoko Kuwata, Haruka Yamaguchi, Tokuzo Arao, Kazuto Nishio, Masahiro Fukuoka, Pasi A. Jänne, Kazuhiko Nakagawa
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (10): 2785–2792.
https://doi.org/10.1158/1535-7163.MCT-10-0481
Published: 10 October 2010
View article titled, TAK-701, a Humanized Monoclonal Antibody to Hepatocyte Growth Factor, Reverses Gefitinib Resistance Induced by Tumor-Derived HGF in Non–Small Cell Lung Cancer with an <em>EGFR</em> Mutation
Open the PDF for TAK-701, a Humanized Monoclonal Antibody to Hepatocyte Growth Factor, Reverses Gefitinib Resistance Induced by Tumor-Derived HGF in Non–Small Cell Lung Cancer with an <em>EGFR</em> Mutation in another window
Journal Articles

Phase I Safety, Pharmacokinetic, and Biomarker Study of BIBF 1120, an Oral Triple Tyrosine Kinase Inhibitor in Patients with Advanced Solid Tumors

Isamu Okamoto, Hiroyasu Kaneda, Taroh Satoh, Wataru Okamoto, Masaki Miyazaki, Ryotaro Morinaga, Shinya Ueda, Masaaki Terashima, Asuka Tsuya, Akiko Sarashina, Koichi Konishi, Tokuzo Arao, Kazuto Nishio, Rolf Kaiser, Kazuhiko Nakagawa
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (10): 2825–2833.
https://doi.org/10.1158/1535-7163.MCT-10-0379
Published: 10 October 2010
View article titled, Phase I Safety, Pharmacokinetic, and Biomarker Study of BIBF 1120, an Oral Triple Tyrosine Kinase Inhibitor in Patients with Advanced Solid Tumors
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Includes: Supplementary data
Journal Articles

Enhanced Anticancer Effect of the Combination of BIBW2992 and Thymidylate Synthase–Targeted Agents in Non–Small Cell Lung Cancer with the T790M Mutation of Epidermal Growth Factor Receptor

Ken Takezawa, Isamu Okamoto, Junko Tanizaki, Kiyoko Kuwata, Haruka Yamaguchi, Masahiro Fukuoka, Kazuto Nishio, Kazuhiko Nakagawa
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (6): 1647–1656.
https://doi.org/10.1158/1535-7163.MCT-09-1009
Published: 09 June 2010
View article titled, Enhanced Anticancer Effect of the Combination of BIBW2992 and Thymidylate Synthase–Targeted Agents in Non–Small Cell Lung Cancer with the T790M Mutation of Epidermal Growth Factor Receptor
Open the PDF for Enhanced Anticancer Effect of the Combination of BIBW2992 and Thymidylate Synthase–Targeted Agents in Non–Small Cell Lung Cancer with the T790M Mutation of Epidermal Growth Factor Receptor in another window
Includes: Supplementary data
Journal Articles

Identification of c-Src as a Potential Therapeutic Target for Gastric Cancer and of MET Activation as a Cause of Resistance to c-Src Inhibition

Wataru Okamoto, Isamu Okamoto, Takeshi Yoshida, Kunio Okamoto, Ken Takezawa, Erina Hatashita, Yuki Yamada, Kiyoko Kuwata, Tokuzo Arao, Kazuyoshi Yanagihara, Masahiro Fukuoka, Kazuto Nishio, Kazuhiko Nakagawa
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (5): 1188–1197.
https://doi.org/10.1158/1535-7163.MCT-10-0002
Published: 09 May 2010
View article titled, Identification of c-Src as a Potential Therapeutic Target for Gastric Cancer and of MET Activation as a Cause of Resistance to c-Src Inhibition
Open the PDF for Identification of c-Src as a Potential Therapeutic Target for Gastric Cancer and of MET Activation as a Cause of Resistance to c-Src Inhibition in another window
Includes: Supplementary data
Journal Articles

EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell line

Junya Fukai, Hideyuki Yokote, Ryuya Yamanaka, Tokuzo Arao, Kazuto Nishio, Toru Itakura
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (9): 2768–2778.
https://doi.org/10.1158/1535-7163.MCT-07-2263
Published: 11 September 2008
View article titled, EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell line
Open the PDF for EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell line in another window
Includes: Supplementary data