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Karen Rex
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Journal Articles

Dual Inhibition of Angiopoietin-TIE2 and MET Alters the Tumor Microenvironment and Prolongs Survival in a Metastatic Model of Renal Cell Carcinoma

May Elbanna, Ashley R. Orillion, Nur P. Damayanti, Remi Adelaiye-Ogala, Li Shen, Kiersten Marie Miles, Sreenivasulu Chintala, Eric Ciamporcero, Swathi Ramakrishnan, Sheng-yu Ku, Karen Rex, Sean Caenepeel, Angela Coxon, Roberto Pili
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2020) 19 (1): 147–156.
https://doi.org/10.1158/1535-7163.MCT-18-1202
Published: 03 January 2020
View article titled, Dual Inhibition of Angiopoietin-TIE2 and MET Alters the Tumor Microenvironment and Prolongs Survival in a Metastatic Model of Renal Cell Carcinoma
Open the PDF for Dual Inhibition of Angiopoietin-TIE2 and MET Alters the Tumor Microenvironment and Prolongs Survival in a Metastatic Model of Renal Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models

Paul E. Hughes, Karen Rex, Sean Caenepeel, Yajing Yang, Yihong Zhang, Martin A. Broome, Hue T. Kha, Teresa L. Burgess, Benny Amore, Paula J. Kaplan-Lefko, Jodi Moriguchi, Jonathan Werner, Michael A. Damore, Daniel Baker, Deborah M. Choquette, Jean-Christophe Harmange, Robert Radinsky, Richard Kendall, Isabelle Dussault, Angela Coxon
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (7): 1568–1579.
https://doi.org/10.1158/1535-7163.MCT-15-0871
Published: 05 July 2016
View article titled, <em>In Vitro</em> and <em>In Vivo</em> Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models
Open the PDF for <em>In Vitro</em> and <em>In Vivo</em> Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models in another window
Includes: Supplementary data
Journal Articles

Preclinical Evaluation of AMG 337, a Highly Selective Small Molecule MET Inhibitor, in Hepatocellular Carcinoma

Zhiqiang Du, Sean Caenepeel, Yuqing Shen, Karen Rex, Yanni Zhang, Ying He, En-Tzu Tang, Ouhong Wang, Wenge Zhong, Hui Zhou, Jacqueline Huang, Eric Huang, Liaoyuan Hu, Angela Coxon, Mingqiang Zhang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (6): 1227–1237.
https://doi.org/10.1158/1535-7163.MCT-15-0745
Published: 02 June 2016
View article titled, Preclinical Evaluation of AMG 337, a Highly Selective Small Molecule MET Inhibitor, in Hepatocellular Carcinoma
Open the PDF for Preclinical Evaluation of AMG 337, a Highly Selective Small Molecule MET Inhibitor, in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract A204: A cellular model of acquired resistance to rilotumumab (AMG 102) in glioblastoma.

Fabiola Cecchi, Karen Rex, Joanna Schmidt, Daniel Baker, Michael A. Damore, Angela Coxon, Teresa L. Burgess, Donald P. Bottaro
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): A204.
https://doi.org/10.1158/1535-7163.TARG-11-A204
Published: 12 November 2011
View article titled, Abstract A204: A cellular model of acquired resistance to rilotumumab (AMG 102) in glioblastoma.
Journal Articles

Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody

Angela Coxon, James Bready, Hosung Min, Stephen Kaufman, Juan Leal, Dongyin Yu, Tani Ann Lee, Ji-Rong Sun, Juan Estrada, Brad Bolon, James McCabe, Ling Wang, Karen Rex, Sean Caenepeel, Paul Hughes, David Cordover, Haejin Kim, Seog Joon Han, Mark L. Michaels, Eric Hsu, Grant Shimamoto, Russell Cattley, Eunju Hurh, Linh Nguyen, Shao Xiong Wang, Anthony Ndifor, Isaac J. Hayward, Beverly L. Falcón, Donald M. McDonald, Luke Li, Tom Boone, Richard Kendall, Robert Radinsky, Jonathan D. Oliner
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (10): 2641–2651.
https://doi.org/10.1158/1535-7163.MCT-10-0213
Published: 10 October 2010
View article titled, Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody
Open the PDF for Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody in another window
Includes: Supplementary data
Journal Articles

Therapeutic potential of hepatocyte growth factor/scatter factor neutralizing antibodies: Inhibition of tumor growth in both autocrine and paracrine hepatocyte growth factor/scatter factor:c-Met-driven models of leiomyosarcoma

Chong-Feng Gao, Qian Xie, Yu-Wen Zhang, Yanli Su, Ping Zhao, Brian Cao, Kyle Furge, Jan Sun, Karen Rex, Tao Osgood, Angela Coxon, Teresa L. Burgess, George F. Vande Woude
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (10): 2803–2810.
https://doi.org/10.1158/1535-7163.MCT-09-0125
Published: 12 October 2009
View article titled, Therapeutic potential of hepatocyte growth factor/scatter factor neutralizing antibodies: Inhibition of tumor growth in both autocrine and paracrine hepatocyte growth factor/scatter factor:c-Met-driven models of leiomyosarcoma
Open the PDF for Therapeutic potential of hepatocyte growth factor/scatter factor neutralizing antibodies: Inhibition of tumor growth in both autocrine and paracrine hepatocyte growth factor/scatter factor:c-Met-driven models of leiomyosarcoma in another window
Journal Articles

Soluble c-Met receptors inhibit phosphorylation of c-Met and growth of hepatocyte growth factor: c-Met–dependent tumors in animal models

Angela Coxon, Karen Rex, Susanne Meyer, Jianling Sun, Jilin Sun, Qing Chen, Robert Radinsky, Richard Kendall, Teresa L. Burgess
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (5): 1119–1125.
https://doi.org/10.1158/1535-7163.MCT-08-1032
Published: 13 May 2009
View article titled, Soluble c-Met receptors inhibit phosphorylation of c-Met and growth of hepatocyte growth factor: c-Met–dependent tumors in animal models
Open the PDF for Soluble c-Met receptors inhibit phosphorylation of c-Met and growth of hepatocyte growth factor: c-Met–dependent tumors in animal models in another window
Journal Articles

Identification and characterization of a novel RON/c-Met small molecule inhibitor

Yihong Zhang, Paula Kaplan-Lefko, Karen Rex, Yajing Yang, Jodi Moriguchi, Tao Osgood, Bethany Mattson, Angela Coxon, Teresa Burgess, Isabelle Dussault
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): A223.
Published: 01 November 2007
View article titled, Identification and characterization of a novel RON/c-Met small molecule inhibitor