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Karen Lundgren
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Journal Articles

Abstract LBA022: IMM20324, a first-in-class, anti-interleukin-38 monoclonal antibody, rescues myeloid cell activation in vitro and induces robust anti-tumor responses in vivo

John P Dowling, Pavel A Nikitin, Fang Shen, James P Finn, Nirja Patel, Cezary Swider, Jamie Steele, Halley Shukla, Matthew K Robinson, Karen Lundgren, Benjamin C Harman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): LBA022.
https://doi.org/10.1158/1535-7163.TARG-21-LBA022
Published: 01 December 2021
View article titled, Abstract LBA022: IMM20324, a first-in-class, anti-interleukin-38 monoclonal antibody, rescues myeloid cell activation <em>in vitro</em> and induces robust anti-tumor responses <em>in vivo</em>
Journal Articles

Abstract B35: Validation of a multiplex method for detection of several oncosignaling proteins with potential utility for assessment of pharmacodynamic activity of hsp90 inhibitors

Lori Hipolito, Naveen Dakappagari, Daniel Stenzel, Laura Pierce, Noelito Timple, Gerardo Ibanez, Karen Lundgren, Sarah Harris, Shabnam Tangri
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): B35.
https://doi.org/10.1158/1535-7163.TARG-09-B35
Published: 10 December 2009
View article titled, Abstract B35: Validation of a multiplex method for detection of several oncosignaling proteins with potential utility for assessment of pharmacodynamic activity of hsp90 inhibitors
Journal Articles

BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90

Karen Lundgren, Hong Zhang, John Brekken, Nanni Huser, Rachel E. Powell, Noel Timple, David J. Busch, Laura Neely, John L. Sensintaffar, Yong-ching Yang, Andres McKenzie, Jessica Friedman, Robert Scannevin, Adeela Kamal, Kevin Hong, Srinivas R. Kasibhatla, Marcus F. Boehm, Francis J. Burrows
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (4): 921–929.
https://doi.org/10.1158/1535-7163.MCT-08-0758
Published: 16 April 2009
View article titled, BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90
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Journal Articles

Pharmacologic properties of AG-012986, a pan-cyclin-dependent kinase inhibitor with antitumor efficacy

Cathy Zhang, Karen Lundgren, Zhengming Yan, Maria E. Arango, Sharon Price, Andrea Huber, Joseph Higgins, Gabriel Troche, Judith Skaptason, Tatiana Koudriakova, Jim Nonomiya, Michelle Yang, Patrick O'Connor, Steve Bender, Gerrit Los, Cristina Lewis, Bart Jessen
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (4): 818–828.
https://doi.org/10.1158/1535-7163.MCT-07-0440
Published: 15 April 2008
View article titled, Pharmacologic properties of AG-012986, a pan-cyclin-dependent kinase inhibitor with antitumor efficacy
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Journal Articles

Targeting Hsp90 using EC154, a novel synthetic Hsp90 inhibitor, impairs multiple signaling pathways in human gastric and pancreatic cancer cells and reduces tumor growth in vivo

Oliver Stoeltzing, Christian Moser, Sven Lang, Karen Lundgren, Hans Schlitt, Hong Zhang, Francis Burrows
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): C170.
Published: 01 November 2007
View article titled, Targeting Hsp90 using EC154, a novel synthetic Hsp90 inhibitor, impairs multiple signaling pathways in human gastric and pancreatic cancer cells and reduces tumor growth in vivo
Journal Articles

BIIB021 is a small molecule inhibitor of the heat shock protein, Hsp90, that shows potent anti-tumor activity in preclinical models

Karen Lundgren, Hong Zhang, Adeela Kamal, Rachel Lough, Noelito Timple, John Sensintaffar, David Busch, Cindy Yang, Laura Neely, Samina Khan, Kevin Hong, Srinivas Kasibhatla, Marcus Boehm, Francis Burrows
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B161.
Published: 01 November 2007
View article titled, BIIB021 is a small molecule inhibitor of the heat shock protein, Hsp90, that shows potent anti-tumor activity in preclinical models
Journal Articles

Synthetic Hsp90 inhibitors are active against 17-AAG-resistant tumor lines

Laura Neely, Cindy Yang, Rachel Lough, Noel Timple, Karen Lundgren, Francis Burrows, Hong Zhang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): A122.
Published: 01 November 2007
View article titled, Synthetic Hsp90 inhibitors are active against 17-AAG-resistant tumor lines
Journal Articles

Proteomics analysis of Hsp90 modulation

Jing Wei, Mark Daniels, Ben Colson, Diem Tran, John Sensintaffar, Noel Timple, Naveen Dakappagari, Adeela Kamal, Karen Lundgren, Ingrid Joseph, Shabnam Tangri, Chris Storgard, Alessandra Cesano, Steve French, Steve French, Francis Burrows, Alex Buko
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B160.
Published: 01 November 2007
View article titled, Proteomics analysis of Hsp90 modulation
Journal Articles

Identification of new biomarkers for clinical trials of Hsp90 inhibitors

Hong Zhang, Daun Chung, Yong-Ching Yang, Laura Neely, Steven Tsurumoto, Junhua Fan, Lin Zhang, Marco Biamonte, John Brekken, Karen Lundgren, Francis Burrows
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2006) 5 (5): 1256–1264.
https://doi.org/10.1158/1535-7163.MCT-05-0537
Published: 26 May 2006
View article titled, Identification of new biomarkers for clinical trials of Hsp90 inhibitors
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