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Junko Murai
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Journal Articles

SLFN11 is a BRCA independent biomarker for the response to platinum-based chemotherapy in high-grade serous ovarian cancer and clear cell ovarian carcinoma

Hidehiko Akashi, Nozomi Yachida, Haruka Ueda, Manako Yamaguchi, Kaoru Yamawaki, Ryo Tamura, Kazuaki Suda, Tatsuya Ishiguro, Sosuke Adachi, Yoshikazu Nagase, Yutaka Ueda, Masashi Ueda, Kaoru Abiko, Masahiro Kagabu, Tsukasa Baba, Hirofumi Nakaoka, Takayuki Enomoto, Junko Murai, Kosuke Yoshihara
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023)
https://doi.org/10.1158/1535-7163.MCT-23-0257
Published: 15 September 2023
View article titled, SLFN11 is a BRCA independent biomarker for the response to platinum-based chemotherapy in high-grade serous ovarian cancer and clear cell ovarian carcinoma
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Includes: Supplementary data
Journal Articles

Schlafen 11 (SLFN11) Kills Cancer Cells Undergoing Unscheduled Re-replication

Junko Murai, Michele Ceribelli, Haiqing Fu, Christophe E. Redon, Ukhyun Jo, Yasuhisa Murai, Mirit I. Aladjem, Craig J. Thomas, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (8): 985–995.
https://doi.org/10.1158/1535-7163.MCT-22-0552
Published: 01 August 2023
View article titled, Schlafen 11 (SLFN11) Kills Cancer Cells Undergoing Unscheduled Re-replication
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Includes: Supplementary data
Journal Articles

Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors

Laetitia Marzi, Keli Agama, Junko Murai, Simone Difilippantonio, Amy James, Cody J. Peer, William D. Figg, Daniel Beck, Mohamed S.A. Elsayed, Mark Cushman, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (8): 1694–1704.
https://doi.org/10.1158/1535-7163.MCT-18-0028
Published: 31 July 2018
View article titled, Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors
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Includes: Supplementary data
Journal Articles

Abstract CN05-03: Precision therapeutics with DNA-damaging agents

Yves G. Pommier, William C. Reinhold, Junko Murai, Anish Thomas
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): CN05-03.
https://doi.org/10.1158/1535-7163.TARG-17-CN05-03
Published: 01 January 2018
View article titled, Abstract CN05-03: Precision therapeutics with DNA-damaging agents
Journal Articles

Abstract PL05-04: PARP trapping versus PARP catalytic inhibition and coupling with TDP1

Yves G. Pommier, Junko Murai
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): PL05-04.
https://doi.org/10.1158/1535-7163.TARG-15-PL05-04
Published: 01 December 2015
View article titled, Abstract PL05-04: PARP trapping versus PARP catalytic inhibition and coupling with TDP1
Journal Articles

Abstract B64: Schlafen 11 (SLFN11) irreversibly blocks cell cycle recovery independently of ATR following replicative damage by poly(ADPribose) polymerase inhibitors

Junko Murai, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): B64.
https://doi.org/10.1158/1535-7163.TARG-15-B64
Published: 01 December 2015
View article titled, Abstract B64: Schlafen 11 (SLFN11) irreversibly blocks cell cycle recovery independently of ATR following replicative damage by poly(ADPribose) polymerase inhibitors
Journal Articles

Abstract C56: Platinum containing anti-cancer agents as targeted therapeutics

Peter M. Bruno, Ga Young Park, Junko Murai, Yunpeng Liu, Justin Pritchard, Yves Pommier, Stephen J. Lippard, Michael T. Hemann
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): C56.
https://doi.org/10.1158/1535-7163.TARG-15-C56
Published: 01 December 2015
View article titled, Abstract C56: Platinum containing anti-cancer agents as targeted therapeutics
Journal Articles

Biochemical Assays for the Discovery of TDP1 Inhibitors

Christophe Marchand, Shar-yin N. Huang, Thomas S. Dexheimer, Wendy A. Lea, Bryan T. Mott, Adel Chergui, Alena Naumova, Andrew G. Stephen, Andrew S. Rosenthal, Ganesha Rai, Junko Murai, Rui Gao, David J. Maloney, Ajit Jadhav, William L. Jorgensen, Anton Simeonov, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2014) 13 (8): 2116–2126.
https://doi.org/10.1158/1535-7163.MCT-13-0952
Published: 05 August 2014
View article titled, Biochemical Assays for the Discovery of TDP1 Inhibitors
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Includes: Supplementary data
Journal Articles

Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib

Junko Murai, Shar-Yin N. Huang, Amèlie Renaud, Yiping Zhang, Jiuping Ji, Shunichi Takeda, Joel Morris, Beverly Teicher, James H. Doroshow, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2014) 13 (2): 433–443.
https://doi.org/10.1158/1535-7163.MCT-13-0803
Published: 09 February 2014
View article titled, Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib
Open the PDF for Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib in another window
Includes: Supplementary data
Journal Articles

Differential and Common DNA Repair Pathways for Topoisomerase I- and II-Targeted Drugs in a Genetic DT40 Repair Cell Screen Panel

Yuko Maede, Hiroyasu Shimizu, Toru Fukushima, Toshiaki Kogame, Terukazu Nakamura, Tsuneharu Miki, Shunichi Takeda, Yves Pommier, Junko Murai
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2014) 13 (1): 214–220.
https://doi.org/10.1158/1535-7163.MCT-13-0551
Published: 13 January 2014
View article titled, Differential and Common DNA Repair Pathways for Topoisomerase I- and II-Targeted Drugs in a Genetic DT40 Repair Cell Screen Panel
Open the PDF for Differential and Common DNA Repair Pathways for Topoisomerase I- and II-Targeted Drugs in a Genetic DT40 Repair Cell Screen Panel in another window
Includes: Supplementary data
Journal Articles

Abstract A257: Stereospecific trapping of PARP-DNA complexes by BMN 673 and comparison with olaparib and rucaparib.

Junko Murai, Shar-yin N. Huang, Amelie Renaud, Yiping Zhang, Jiuping Ji, Shunichi Takeda, Joel Morris, Beverly Teicher, James H. Doroshow, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): A257.
https://doi.org/10.1158/1535-7163.TARG-13-A257
Published: 01 November 2013
View article titled, Abstract A257: Stereospecific trapping of PARP-DNA complexes by BMN 673 and comparison with olaparib and rucaparib.
Journal Articles

Abstract CN05-01: PARP inhibitors: Trapping of PARP and rational for combinations.

Yves G. Pommier, Junko Murai, Joel Morris, James H. Doroshow
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): CN05-01.
https://doi.org/10.1158/1535-7163.TARG-13-CN05-01
Published: 01 November 2013
View article titled, Abstract CN05-01: PARP inhibitors: Trapping of PARP and rational for combinations.
Journal Articles

Abstract C79: TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.

Shar-Yin N. Huang, Junko Murai, Ilaria Dalla Rosa, Thomas S. Dexheimer, William H. Gmeiner, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): C79.
https://doi.org/10.1158/1535-7163.TARG-13-C79
Published: 01 November 2013
View article titled, Abstract C79: TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.