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John N. Weinstein
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Journal Articles

Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia

Wai-Kin Chan, Thomas D. Horvath, Lin Tan, Todd Link, Karine G. Harutyunyan, Michael A. Pontikos, Andriy Anishkin, Di Du, Leona A. Martin, Eric Yin, Susan B. Rempe, Sergei Sukharev, Marina Konopleva, John N. Weinstein, Philip L. Lorenzi
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2019) 18 (9): 1587–1592.
https://doi.org/10.1158/1535-7163.MCT-18-1329
Published: 03 September 2019
View articletitled, Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia
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Includes: Supplementary data
Journal Articles

Abstract B130: The intratumoral heterogeneity of glioblastoma suggests a pivotal role for clonal evolution.

Hoon Kim, Siyuan Zheng, Seyed S. Amini, Selene Virk, Tom Mikkelsen, Daniel J. Brat, Jonna Grimsby, Carrie Sougnez, Andrew E. Sloan, Mark L. Cohen, Erwin G. Van Meir, Lisa Scarpace, Peter W. Laird, John N. Weinstein, Eric S. Lander, Stacey Gabriel, Gaddy Getz, Matthew Meyerson, Lynda Chin, Jill S. Barnholtz-Sloan, Roeland GW Verhaak
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): B130.
https://doi.org/10.1158/1535-7163.TARG-13-B130
Published: 01 November 2013
View articletitled, Abstract B130: The intratumoral heterogeneity of glioblastoma suggests a pivotal role for clonal evolution.
Journal Articles

Abstract C117: An integrated proteomic analysis of lung adenocarcinomas from The Cancer Genome Atlas (TCGA) reveals potential targets for oncogene-negative tumors.

Lixia Diao, Pan Tong, Jing Wang, You-Hong Fan, Yiling Lu, Wenbin Liu, Carmen Behrens, Ignacio I. Wistuba, John V. Heymach, John N. Weinstein, Gordon B. Mills, Lauren A. Byers
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): C117.
https://doi.org/10.1158/1535-7163.TARG-13-C117
Published: 01 November 2013
View articletitled, Abstract C117: An integrated proteomic analysis of lung adenocarcinomas from The Cancer Genome Atlas (TCGA) reveals potential targets for oncogene-negative tumors.
Journal Articles

Abstract A131: Identification of candidate therapeutic targets in mesenchymal head and neck squamous cell carcinoma.

Milena P. Mak, Lixia Diao, Jing Wang, Patrick KS Ng, You-Hong Fan, Michael D. Story, William N. William, John V. Heymach, John N. Weinstein, Kevin R. Coombes, Lauren A. Byers
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): A131.
https://doi.org/10.1158/1535-7163.TARG-13-A131
Published: 01 November 2013
View articletitled, Abstract A131: Identification of candidate therapeutic targets in mesenchymal head and neck squamous cell carcinoma.
Journal Articles

Abstract B156: An epithelial to mesenchymal transition (EMT) gene expression signature predicts resistance to PI3K/Akt pathway inhibitors in non-small cell lung cancer.

Lauren Averett Byers, Jing Wang, Lixia Diao, Luc Girard, Michael Peyton, Kevin R. Coombes, John N. Weinstein, Varsha Gandi, Nancy Krett, Steven T. Rosen, John D. Minna, John V. Heymach
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): B156.
https://doi.org/10.1158/1535-7163.TARG-11-B156
Published: 12 November 2011
View articletitled, Abstract B156: An epithelial to mesenchymal transition (EMT) gene expression signature predicts resistance to PI3K/Akt pathway inhibitors in non-small cell lung cancer.
Journal Articles

MicroRNAs in Cancer Pharmacology and Therapeutics: Exploiting a Natural Synergy between ‘-omic’ and Hypothesis-Driven Research

John N. Weinstein
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11): 2021.
https://doi.org/10.1158/1535-7163.MCT-11-0766
Published: 08 November 2011
View articletitled, MicroRNAs in Cancer Pharmacology and Therapeutics: Exploiting a Natural Synergy between ‘-omic’ and Hypothesis-Driven Research
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Journal Articles

mRNA and microRNA Expression Profiles of the NCI-60 Integrated with Drug Activities

Hongfang Liu, Petula D'Andrade, Stephanie Fulmer-Smentek, Philip Lorenzi, Kurt W. Kohn, John N. Weinstein, Yves Pommier, William C. Reinhold
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (5): 1080–1091.
https://doi.org/10.1158/1535-7163.MCT-09-0965
Published: 09 May 2010
View articletitled, mRNA and microRNA Expression Profiles of the NCI-60 Integrated with Drug Activities
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Includes: Supplementary data
Journal Articles

Integrative Analysis of Proteomic Signatures, Mutations, and Drug Responsiveness in the NCI 60 Cancer Cell Line Set

Eun Sung Park, Rosalia Rabinovsky, Mark Carey, Bryan T. Hennessy, Roshan Agarwal, Wenbin Liu, Zhenlin Ju, Wanleng Deng, Yiling Lu, Hyun Goo Woo, Sang-Bae Kim, Jae-Ho Cheong, Levi A. Garraway, John N. Weinstein, Gordon B. Mills, Ju-Seog Lee, Michael A. Davies
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (2): 257–267.
https://doi.org/10.1158/1535-7163.MCT-09-0743
Published: 09 February 2010
View articletitled, Integrative Analysis of Proteomic Signatures, Mutations, and Drug Responsiveness in the NCI 60 Cancer Cell Line Set
Open the PDF for Integrative Analysis of Proteomic Signatures, Mutations, and Drug Responsiveness in the NCI 60 Cancer Cell Line Set in another window
Includes: Supplementary data
Journal Articles

Multifactorial Regulation of E-Cadherin Expression: An Integrative Study

William C. Reinhold, Mark A. Reimers, Philip Lorenzi, Jennifer Ho, Uma T. Shankavaram, Micah S. Ziegler, Kimberly J. Bussey, Satoshi Nishizuka, Ogechi Ikediobi, Yves G. Pommier, John N. Weinstein
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (1): 1–16.
https://doi.org/10.1158/1535-7163.MCT-09-0321
Published: 12 January 2010
View articletitled, Multifactorial Regulation of E-Cadherin Expression: An Integrative Study
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Journal Articles

Abstract C149: Exon array analyses across the NCI‐60 reveals potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron

William C. Reinhold, Jean‐Louis Mergny, Hongfang Liu, Michael Ryan, Thomas D. Pfister, Robert Kinders, Ralph Parchment, James Doroshow, John N. Weinstein, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): C149.
https://doi.org/10.1158/1535-7163.TARG-09-C149
Published: 10 December 2009
View articletitled, Abstract C149: Exon array analyses across the NCI‐60 reveals potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron
Journal Articles

Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database

Josiah N. Orina, Anna Maria Calcagno, Chung-Pu Wu, Sudhir Varma, Joanna Shih, Min Lin, Gabriel Eichler, John N. Weinstein, Yves Pommier, Suresh V. Ambudkar, Michael M. Gottesman, Jean-Pierre Gillet
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (7): 2057–2066.
https://doi.org/10.1158/1535-7163.MCT-09-0256
Published: 14 July 2009
View articletitled, Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database
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Includes: Supplementary data
Journal Articles

DNA fingerprinting of the NCI-60 cell line panel

Philip L. Lorenzi, William C. Reinhold, Sudhir Varma, Amy A. Hutchinson, Yves Pommier, Stephen J. Chanock, John N. Weinstein
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (4): 713–724.
https://doi.org/10.1158/1535-7163.MCT-08-0921
Published: 16 April 2009
View articletitled, DNA fingerprinting of the NCI-60 cell line panel
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Includes: Supplementary data
Journal Articles

Asparagine synthetase is a predictive biomarker of l-asparaginase activity in ovarian cancer cell lines

Philip L. Lorenzi, Jenny Llamas, Michele Gunsior, Laurent Ozbun, William C. Reinhold, Sudhir Varma, Helen Ji, Hijoo Kim, Amy A. Hutchinson, Elise C. Kohn, Paul K. Goldsmith, Michael J. Birrer, John N. Weinstein
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (10): 3123–3128.
https://doi.org/10.1158/1535-7163.MCT-08-0589
Published: 13 October 2008
View articletitled, Asparagine synthetase is a predictive biomarker of l-asparaginase activity in ovarian cancer cell lines
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Includes: Supplementary data
Journal Articles

Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters

Mitsunori Okabe, Gergely Szakács, Mark A. Reimers, Toshihiro Suzuki, Matthew D. Hall, Takaaki Abe, John N. Weinstein, Michael M. Gottesman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (9): 3081–3091.
https://doi.org/10.1158/1535-7163.MCT-08-0539
Published: 11 September 2008
View articletitled, Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters
Open the PDF for Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters in another window
Includes: Supplementary data
Journal Articles

In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation

Ogechi N. Ikediobi, Mark Reimers, Steffen Durinck, Paul E. Blower, Andrew P. Futreal, Michael R. Stratton, John N. Weinstein
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (6): 1337–1346.
https://doi.org/10.1158/1535-7163.MCT-07-2308
Published: 19 June 2008
View articletitled, In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation
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Includes: Supplementary data
Journal Articles

Predicting cisplatin and trabectedin drug sensitivity in ovarian and colon cancers

Ellen V. Stevens, Satoshi Nishizuka, Smitha Antony, Mark Reimers, Sudhir Varma, Lynn Young, Peter J. Munson, John N. Weinstein, Elise C. Kohn, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (1): 10–18.
https://doi.org/10.1158/1535-7163.MCT-07-0192
Published: 17 January 2008
View articletitled, Predicting cisplatin and trabectedin drug sensitivity in ovarian and colon cancers
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Journal Articles

MicroRNAs modulate the chemosensitivity of tumor cells

Paul E. Blower, Ji-Hyun Chung, Joseph S. Verducci, Shili Lin, Jong-Kook Park, Zunyan Dai, Chang-Gong Liu, Thomas D. Schmittgen, William C. Reinhold, Carlo M. Croce, John N. Weinstein, Wolfgang Sadee
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (1): 1–9.
https://doi.org/10.1158/1535-7163.MCT-07-0573
Published: 17 January 2008
View articletitled, MicroRNAs modulate the chemosensitivity of tumor cells
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Includes: Supplementary data
Journal Articles

MicroRNA expression profiles for the NCI-60 cancer cell panel

Paul E. Blower, Joseph S. Verducci, Shili Lin, Jin Zhou, Ji-Hyun Chung, Zunyan Dai, Chang-Gong Liu, William Reinhold, Philip L. Lorenzi, Eric P. Kaldjian, Carlo M. Croce, John N. Weinstein, Wolfgang Sadee
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (5): 1483–1491.
https://doi.org/10.1158/1535-7163.MCT-07-0009
Published: 18 May 2007
View articletitled, MicroRNA expression profiles for the NCI-60 cancer cell panel
Open the PDF for MicroRNA expression profiles for the NCI-60 cancer cell panel in another window
Includes: Supplementary data
Journal Articles

Transcript and protein expression profiles of the NCI-60 cancer cell panel: an integromic microarray study

Uma T. Shankavaram, William C. Reinhold, Satoshi Nishizuka, Sylvia Major, Daisaku Morita, Krishna K. Chary, Mark A. Reimers, Uwe Scherf, Ari Kahn, Douglas Dolginow, Jeffrey Cossman, Eric P. Kaldjian, Dominic A. Scudiero, Emanuel Petricoin, Lance Liotta, Jae K. Lee, John N. Weinstein
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (3): 820–832.
https://doi.org/10.1158/1535-7163.MCT-06-0650
Published: 15 March 2007
View articletitled, Transcript and protein expression profiles of the NCI-60 cancer cell panel: an integromic microarray study
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Journal Articles

Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells

William C. Reinhold, Mark A. Reimers, Alika K. Maunakea, Sohyoung Kim, Samir Lababidi, Uwe Scherf, Uma T. Shankavaram, Micah S. Ziegler, Claudia Stewart, Hosein Kouros-Mehr, Hengmi Cui, Douglas Dolginow, Dominic A. Scudiero, Yves G. Pommier, David J. Munroe, Andrew P. Feinberg, John N. Weinstein
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (2): 391–403.
https://doi.org/10.1158/1535-7163.MCT-06-0609
Published: 16 February 2007
View articletitled, Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells
Open the PDF for Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells in another window