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Johanna Lahdenranta
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Journal Articles

BT8009; A Nectin-4 Targeting Bicycle Toxin Conjugate for Treatment of Solid Tumors

Michael Rigby, Gavin Bennett, Liuhong Chen, Gemma E. Mudd, Helen Harrison, Paul J. Beswick, Katerine Van Rietschoten, Sophie M. Watcham, Heather S. Scott, Amy N. Brown, Peter U. Park, Carly Campbell, Eric Haines, Johanna Lahdenranta, Michael J. Skynner, Phil Jeffrey, Nicholas Keen, Kevin Lee
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (12): 1747–1756.
https://doi.org/10.1158/1535-7163.MCT-21-0875
Published: 02 December 2022
View article titled, BT8009; A Nectin-4 Targeting Bicycle Toxin Conjugate for Treatment of Solid Tumors
Open the PDF for BT8009; A Nectin-4 Targeting Bicycle Toxin Conjugate for Treatment of Solid Tumors in another window
Includes: Supplementary data
Journal Articles

Comprehensive Surfaceome Profiling to Identify and Validate Novel Cell-Surface Targets in Osteosarcoma

Yifei Wang, Xiangjun Tian, Wendong Zhang, Zhongting Zhang, Rossana Lazcano, Pooja Hingorani, Michael E. Roth, Jonathan D. Gill, Douglas J. Harrison, Zhaohui Xu, Sylvester Jusu, Sankaranarayanan Kannan, Jing Wang, Alexander J. Lazar, Eric J. Earley, Stephen W. Erickson, Tara Gelb, Philip Huxley, Johanna Lahdenranta, Gemma Mudd, Raushan T. Kurmasheva, Peter J. Houghton, Malcolm A. Smith, Edward A. Kolb, Richard Gorlick
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (6): 903–913.
https://doi.org/10.1158/1535-7163.MCT-21-0836
Published: 01 June 2022
View article titled, Comprehensive Surfaceome Profiling to Identify and Validate Novel Cell-Surface Targets in Osteosarcoma
Open the PDF for Comprehensive Surfaceome Profiling to Identify and Validate Novel Cell-Surface Targets in Osteosarcoma in another window
Includes: Supplementary data
Journal Articles

MMAE Delivery Using the Bicycle Toxin Conjugate BT5528

Gavin Bennett, Amy Brown, Gemma Mudd, Philip Huxley, Katerine Van Rietschoten, Silvia Pavan, Liuhong Chen, Sophie Watcham, Johanna Lahdenranta, Nicholas Keen
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2020) 19 (7): 1385–1394.
https://doi.org/10.1158/1535-7163.MCT-19-1092
Published: 02 July 2020
View article titled, MMAE Delivery Using the <em>Bicycle</em> Toxin Conjugate BT5528
Open the PDF for MMAE Delivery Using the <em>Bicycle</em> Toxin Conjugate BT5528 in another window
Includes: Supplementary data
Journal Articles

Abstract C066: BT5528, a Bicycle Toxin Conjugate targeting EphA2: mechanism of action and clinical translation

Gavin Bennett, Amy Brown, Gemma Mudd, Johanna Lahdenranta, Nicholas Keen
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): C066.
https://doi.org/10.1158/1535-7163.TARG-19-C066
Published: 01 December 2019
View article titled, Abstract C066: BT5528, a Bicycle Toxin Conjugate targeting EphA2: mechanism of action and clinical translation
Journal Articles

Abstract C061: BT8009, a Bicycle Toxin Conjugate targeting Nectin-4, shows target selectivity, and efficacy in preclinical large and small tumor models

Michael Rigby, Gavin Bennett, Liuhong Chen, Gemma Mudd, Paul Beswick, Helen Harrison, Sophie Watcham, Heather Allen, Amy Brown, Katerine Van Rietschoten, Philip Jeffrey, Peter U Park, Eric Haines, Nicholas Keen, Johanna Lahdenranta
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): C061.
https://doi.org/10.1158/1535-7163.TARG-19-C061
Published: 01 December 2019
View article titled, Abstract C061: BT8009, a Bicycle Toxin Conjugate targeting Nectin-4, shows target selectivity, and efficacy in preclinical large and small tumor models
Journal Articles

Abstract LB-C25: Inhibition of ERBB3 with MM-121, IGF1-R with MM-141 or Met with MM-131 increases the activity of EGFR inhibitor MM-151 in colorectal cancer models expressing multiple resistance ligands

Marisa J. Wainszelbaum, Jessica Fessler, Johanna Lahdenranta, Olga Burenkova, Nat Gerami-Moayed, Yasmin Hashambhoy-Ramsay, Victoria Rimkunas, Gavin MacBeath
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): LB-C25.
https://doi.org/10.1158/1535-7163.TARG-15-LB-C25
Published: 01 December 2015
View article titled, Abstract LB-C25: Inhibition of ERBB3 with MM-121, IGF1-R with MM-141 or Met with MM-131 increases the activity of EGFR inhibitor MM-151 in colorectal cancer models expressing multiple resistance ligands
Journal Articles

Heregulin–ErbB3-Driven Tumor Growth Persists in PI3 Kinase Mutant Cancer Cells

Defne Yarar, Johanna Lahdenranta, William Kubasek, Ulrik B. Nielsen, Gavin MacBeath
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (9): 2072–2080.
https://doi.org/10.1158/1535-7163.MCT-15-0075
Published: 02 September 2015
View article titled, Heregulin–ErbB3-Driven Tumor Growth Persists in PI3 Kinase Mutant Cancer Cells
Open the PDF for Heregulin–ErbB3-Driven Tumor Growth Persists in PI3 Kinase Mutant Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Abstract A205: Development and application of a platform for analysis of protein biomarkers in clinical biopsies of limited quantity.

Jinyan Du, Johanna Lahdenranta, Bo Zhang, Art Kudla, Charlotte McDonagh
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): A205.
https://doi.org/10.1158/1535-7163.TARG-13-A205
Published: 01 November 2013
View article titled, Abstract A205: Development and application of a platform for analysis of protein biomarkers in clinical biopsies of limited quantity.
Journal Articles

Abstract C118: Optimization of MM-111 and lapatinib dosing regimens using mathematical modeling and quantitative biology.

Daniel C. Kirouac, Johanna Lahdenranta, Ryan Overland, Shinji Oyama, Defne Yarar, Matt Onsum, Charlotte McDonagh, Ulrik Nielson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): C118.
https://doi.org/10.1158/1535-7163.TARG-11-C118
Published: 12 November 2011
View article titled, Abstract C118: Optimization of MM-111 and lapatinib dosing regimens using mathematical modeling and quantitative biology.