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Journal Articles

Abstract LB_C10: An orally available small molecule inhibitor for synthetic lethal targeting of MYC expressing tumors

Qiong Shi, Ting Zhang, Julia Kalashova, Jinhua Li, Chenglu Yang, Hongmei Li, Xiaohu Zhou, Yan Long, Yidan Xia Abuliezi, Gang Lv, Duo Yu, Shenqiu Zhang, Jing Zhang, Thaddeus D Allen, Hong Liu, Dun Yang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): LB_C10.
https://doi.org/10.1158/1535-7163.TARG-23-LB_C10
Published: 01 December 2023
View article titled, Abstract LB_C10: An orally available small molecule inhibitor for synthetic lethal targeting of MYC expressing tumors
Journal Articles

Abstract C064: Combination of D3L-002, an anti-TIGIT/PVRIG bispecific antibody, with D3S-001, a KRAS G12C inhibitor, transformed tumor microenvironment from “cold” to “hot” and achieved durable tumor remission in preclinical models

George Chen, Jing Zhang, Haopeng Rui, Xiaofeng Yang, Tienan Wang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): C064.
https://doi.org/10.1158/1535-7163.TARG-23-C064
Published: 01 December 2023
View article titled, Abstract C064: Combination of D3L-002, an anti-TIGIT/PVRIG bispecific antibody, with D3S-001, a KRAS G12C inhibitor, transformed tumor microenvironment from “cold” to “hot” and achieved durable tumor remission in preclinical models
Journal Articles

APR-246 Enhances Colorectal Cancer Sensitivity to Radiotherapy

Xuqin Xie, Chuanwen Fan, Bin Luo, Jing Zhang, Lasse D. Jensen, Jonas Burman, Carolin Jönsson, Anna Ljusberg, Peter Larsson, Zengren Zhao, Xiao-Feng Sun
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (8): 947–961.
https://doi.org/10.1158/1535-7163.MCT-22-0275
Published: 01 August 2023
View article titled, APR-246 Enhances Colorectal Cancer Sensitivity to Radiotherapy
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Includes: Supplementary data
Journal Articles

Inhibition of AKT Sensitizes Cancer Cells to Antineoplastic Drugs by Downregulating Flap Endonuclease 1

Hong Zhu, Congye Wu, Ting Wu, Wen Xia, Shusheng Ci, Weiru He, Yilan Zhang, Lulu Li, Shiying Zhou, Jing Zhang, Ashlin M. Edick, Anna Zhang, Fei-Yan Pan, Zhigang Hu, Lingfeng He, Zhigang Guo
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12): 2407–2420.
https://doi.org/10.1158/1535-7163.MCT-18-1215
Published: 02 December 2019
View article titled, Inhibition of AKT Sensitizes Cancer Cells to Antineoplastic Drugs by Downregulating Flap Endonuclease 1
Open the PDF for Inhibition of AKT Sensitizes Cancer Cells to Antineoplastic Drugs by Downregulating Flap Endonuclease 1 in another window
Includes: Supplementary data
Journal Articles

Improved Therapeutic Window in BRCA-mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition

Haihong Zhong, Cui Chen, Ravinder Tammali, Shannon Breen, Jing Zhang, Christine Fazenbaker, Maureen Kennedy, James Conway, Brandon W. Higgs, Nicholas Holoweckyj, Rajiv Raja, Jay Harper, Andrew J. Pierce, Ronald Herbst, David A. Tice
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2019) 18 (1): 89–99.
https://doi.org/10.1158/1535-7163.MCT-18-0314
Published: 02 January 2019
View article titled, Improved Therapeutic Window in <em>BRCA</em>-mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition
Open the PDF for Improved Therapeutic Window in <em>BRCA</em>-mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition in another window
Includes: Supplementary data
Journal Articles

Abstract A195: CB-1158 inhibits the immuno-oncology target arginase and causes an immune mediated anti-tumor response

Matthew Gross, Jason Chen, Ethan Emberley, Julie Janes, Weiqun Li, Andy Mackinnon, Alison Pan, Francesco Parlati, Mirna Rodriguez, Susanne Steggerda, Tracy Wang, Melissa Works, Jing Zhang, Winter Zhang, Mark Bennett
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): A195.
https://doi.org/10.1158/1535-7163.TARG-15-A195
Published: 01 December 2015
View article titled, Abstract A195: CB-1158 inhibits the immuno-oncology target arginase and causes an immune mediated anti-tumor response
Journal Articles

Abstract B08: High-throughput synthetic lethal drug screen to identify novel radiation sensitizers for KRAS mutant non-small cell lung cancer

Steven H. Lin, Jing Zhang, Uma Giri, Clifford Stephan, Mary Sobieski, Stephen S. Yoo, John V. Heymach
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (5_Supplement): B08.
https://doi.org/10.1158/1535-7163.PMS-B08
Published: 01 May 2014
View article titled, Abstract B08: High-throughput synthetic lethal drug screen to identify novel radiation sensitizers for KRAS mutant non-small cell lung cancer
Journal Articles

TPCA-1 Is a Direct Dual Inhibitor of STAT3 and NF-κB and Regresses Mutant EGFR-Associated Human Non–Small Cell Lung Cancers

Jing Nan, Yuping Du, Xing Chen, Qifeng Bai, Yuxin Wang, Xinxin Zhang, Ning Zhu, Jing Zhang, Jianwen Hou, Qin Wang, Jinbo Yang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2014) 13 (3): 617–629.
https://doi.org/10.1158/1535-7163.MCT-13-0464
Published: 09 March 2014
View article titled, TPCA-1 Is a Direct Dual Inhibitor of STAT3 and NF-κB and Regresses Mutant EGFR-Associated Human Non–Small Cell Lung Cancers
Open the PDF for TPCA-1 Is a Direct Dual Inhibitor of STAT3 and NF-κB and Regresses Mutant EGFR-Associated Human Non–Small Cell Lung Cancers in another window
Includes: Supplementary data
Journal Articles

Prediction of Colorectal Cancer Relapse and Prognosis by Tissue mRNA Levels of NDRG2

Dake Chu, Zixi Zhang, Yunming Li, Lin Wu, Jing Zhang, Weizhong Wang, Jian Zhang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (1): 47–56.
https://doi.org/10.1158/1535-7163.MCT-10-0614
Published: 10 January 2011
View article titled, Prediction of Colorectal Cancer Relapse and Prognosis by Tissue mRNA Levels of <em>NDRG2</em>
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Journal Articles

Novel small molecule inhibitors of the Axl receptor tyrosine kinase block tumor growth

Sacha Holland, Yuanming Hu, Betty Chang, Alison Pan, Christian Franci, Weiqun Li, Matt Duan, Arthur Bagos, Allan Torneros, John McLaughlin, Jing Zhang, Jiaxin Yu, Pingyu Ding, Thilo Heckrodt, Joanne Litvak, Emily Stauffer, George Clemens, Sarkiz Daniel-Issakani, Polly Pine, Dane Goff, Rajinder Singh, Donald Payan, Yasumichi Hitoshi
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B230.
Published: 01 November 2007
View article titled, Novel small molecule inhibitors of the Axl receptor tyrosine kinase block tumor growth