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Journal Articles

MM-141, an IGF-IR– and ErbB3-Directed Bispecific Antibody, Overcomes Network Adaptations That Limit Activity of IGF-IR Inhibitors

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Jonathan B. Fitzgerald, Bryan W. Johnson, Jason Baum, Sharlene Adams, Sergio Iadevaia, Jian Tang, Victoria Rimkunas, Lihui Xu, Neeraj Kohli, Rachel Rennard, Maja Razlog, Yang Jiao, Brian D. Harms, Kenneth J. Olivier, Jr, Birgit Schoeberl, Ulrik B. Nielsen, Alexey A. Lugovskoy
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2014) 13 (2): 410–425.
https://doi.org/10.1158/1535-7163.MCT-13-0255
Published: 09 February 2014
View articletitled, MM-141, an IGF-IR– and ErbB3-Directed Bispecific Antibody, Overcomes Network Adaptations That Limit Activity of IGF-IR Inhibitors
Open the PDF for MM-141, an IGF-IR– and ErbB3-Directed Bispecific Antibody, Overcomes Network Adaptations That Limit Activity of IGF-IR Inhibitors in another window
Includes: Supplementary data
Journal Articles

Abstract C169: MM-141, a bispecific antibody inhibitor of PI3K/AKT/mTOR, attenuates tumor growth and potentiates everolimus in mouse models of anti-hormonal therapy-resistant ER/PR+ breast cancer.

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Sharlene Adams, Jason Baum, Breanne Sparta, Victoria Rimkunas, Jian Tang, Emily Pace, Shoshana Rosenthal, Adam Camblin, Sergio Iadevaia, Akos Czibere, Ulrik Nielsen, Alexey Lugovskoy
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): C169.
https://doi.org/10.1158/1535-7163.TARG-13-C169
Published: 01 November 2013
View articletitled, Abstract C169: MM-141, a bispecific antibody inhibitor of PI3K/AKT/mTOR, attenuates tumor growth and potentiates everolimus in mouse models of anti-hormonal therapy-resistant ER/PR+ breast cancer.
Journal Articles

Abstract B205: Therapeutically targeting redundant, growth factor-induced prosurvival signaling with MM-141, a novel bispecific antibody targeting IGF-1R and ErbB3.

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Alexey Lugovskoy, Bryan Johnson, Jason Baum, Sharlene Adams, Jian Tang, Neeraj Kohli, Rachel Rennard, Lihui Xu, Yang Jiao, Ulrik Nilesen, Jonathan Fitzgerald
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): B205.
https://doi.org/10.1158/1535-7163.TARG-11-B205
Published: 12 November 2011
View articletitled, Abstract B205: Therapeutically targeting redundant, growth factor-induced prosurvival signaling with MM-141, a novel bispecific antibody targeting IGF-1R and ErbB3.
Journal Articles

Adenovirus-expressed human hyperplasia suppressor gene induces apoptosis in cancer cells

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Lina Wu, Zhixin Li, Yingmei Zhang, Pei Zhang, Xiaohui Zhu, Jing Huang, Teng Ma, Tian Lu, Quansheng Song, Qian Li, Yanhong Guo, Jian Tang, Dalong Ma, Kuang-Hueih Chen, Xiaoyan Qiu
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (1): 222–232.
https://doi.org/10.1158/1535-7163.MCT-07-0382
Published: 17 January 2008
View articletitled, Adenovirus-expressed human hyperplasia suppressor gene induces apoptosis in cancer cells
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