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Jennifer R. Grandis
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Journal Articles

Targeting STAT3 with Proteolysis Targeting Chimeras and Next-Generation Antisense Oligonucleotides

Jamie V. Shiah, Jennifer R. Grandis, Daniel E. Johnson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (2): 219–228.
https://doi.org/10.1158/1535-7163.MCT-20-0599
Published: 05 February 2021
View article titled, Targeting STAT3 with Proteolysis Targeting Chimeras and Next-Generation Antisense Oligonucleotides
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Journal Articles

Pathway-Specific Genome Editing of PI3K/mTOR Tumor Suppressor Genes Reveals that PTEN Loss Contributes to Cetuximab Resistance in Head and Neck Cancer

Hiroki Izumi, Zhiyong Wang, Yusuke Goto, Toshinori Ando, Xingyu Wu, Xuefeng Zhang, Hua Li, Daniel E. Johnson, Jennifer R. Grandis, J. Silvio Gutkind
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2020) 19 (7): 1562–1571.
https://doi.org/10.1158/1535-7163.MCT-19-1036
Published: 02 July 2020
View article titled, Pathway-Specific Genome Editing of PI3K/mTOR Tumor Suppressor Genes Reveals that <em>PTEN</em> Loss Contributes to Cetuximab Resistance in Head and Neck Cancer
Open the PDF for Pathway-Specific Genome Editing of PI3K/mTOR Tumor Suppressor Genes Reveals that <em>PTEN</em> Loss Contributes to Cetuximab Resistance in Head and Neck Cancer in another window
Includes: Supplementary data
Journal Articles

STAT3 Cyclic Decoy Demonstrates Robust Antitumor Effects in Non–Small Cell Lung Cancer

Christian Njatcha, Mariya Farooqui, Adam Kornberg, Daniel E. Johnson, Jennifer R. Grandis, Jill M. Siegfried
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2018) 17 (9): 1917–1926.
https://doi.org/10.1158/1535-7163.MCT-17-1194
Published: 04 September 2018
View article titled, STAT3 Cyclic Decoy Demonstrates Robust Antitumor Effects in Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Abstract A23: Bioinformatic analysis of PTPRK reveals a potential link to STAT3 phosphorylation in HNSCC.

Kelsey P. Pendleton, Vivian W. Lui, Yiling Lu, Breean R. Gilbert, Kevin Levine, Gordon B. Mills, Jennifer R. Grandis
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): A23.
https://doi.org/10.1158/1535-7163.TARG-13-A23
Published: 01 November 2013
View article titled, Abstract A23: Bioinformatic analysis of PTPRK reveals a potential link to STAT3 phosphorylation in HNSCC.
Journal Articles

Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer

Neil E. Bhola, Maria L. Freilino, Sonali C. Joyce, Malabika Sen, Sufi M. Thomas, Anirban Sahu, Andre Cassell, Ching-Shih Chen, Jennifer R. Grandis
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (6): 1236–1246.
https://doi.org/10.1158/1535-7163.MCT-11-0936
Published: 10 June 2012
View article titled, Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer
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Includes: Supplementary data
Journal Articles

Abstract C47: Dual kinase inhibition of EGFR and HER2 can overcome resistance to an EGFR‐targeting agent

Kelly M. Quesnelle, Sonali C. Joyce, Jennifer R. Grandis
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): C47.
https://doi.org/10.1158/1535-7163.TARG-09-C47
Published: 10 December 2009
View article titled, Abstract C47: Dual kinase inhibition of EGFR and HER2 can overcome resistance to an EGFR‐targeting agent
Journal Articles

Bortezomib up-regulates activated signal transducer and activator of transcription-3 and synergizes with inhibitors of signal transducer and activator of transcription-3 to promote head and neck squamous cell carcinoma cell death

Changyou Li, Yan Zang, Malabika Sen, Rebecca J. Leeman-Neill, David SK. Man, Jennifer R. Grandis, Daniel E. Johnson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (8): 2211–2220.
https://doi.org/10.1158/1535-7163.MCT-09-0327
Published: 14 August 2009
View article titled, Bortezomib up-regulates activated signal transducer and activator of transcription-3 and synergizes with inhibitors of signal transducer and activator of transcription-3 to promote head and neck squamous cell carcinoma cell death
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Includes: Supplementary data
Journal Articles

Bortezomib induces apoptosis via Bim and Bik up-regulation and synergizes with cisplatin in the killing of head and neck squamous cell carcinoma cells

Changyou Li, Rongxiu Li, Jennifer R. Grandis, Daniel E. Johnson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (6): 1647–1655.
https://doi.org/10.1158/1535-7163.MCT-07-2444
Published: 19 June 2008
View article titled, Bortezomib induces apoptosis via Bim and Bik up-regulation and synergizes with cisplatin in the killing of head and neck squamous cell carcinoma cells
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Includes: Supplementary data
Journal Articles

Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth

Zhenwen Yan, Huafei Zou, Fang Tian, Jennifer R. Grandis, A. James Mixson, Patrick Y. Lu, Lu-Yuan Li
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (6): 1355–1364.
https://doi.org/10.1158/1535-7163.MCT-08-0104
Published: 19 June 2008
View article titled, Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth
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Includes: Supplementary data