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Igor Feldman
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Journal Articles

Abstract P105: Targeting VSIG4, a novel macrophage checkpoint, repolarizes suppressive macrophages which induces an inflammatory response in primary cell in vitro assays and fresh human tumor cultures

Free
Steve Sazinsky, Ani Nguyen, Mohammad Zafari, Ryan Phennicie, Joe Wahle, Veronica Komoroski, Kathryn Rooney, Craig Mizzoni, Boris Klebanov, Jessica Ritter, Denise Manfra, Igor Feldman, Tatiana Novobrantseva
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P105.
https://doi.org/10.1158/1535-7163.TARG-21-P105
Published: 01 December 2021
View articletitled, Abstract P105: Targeting VSIG4, a novel macrophage checkpoint, repolarizes suppressive macrophages which induces an inflammatory response in primary cell in vitro assays and fresh human tumor cultures
Journal Articles

Abstract P107: PSGL-1 blocking antibodies repolarize tumor associated macrophages, reduce suppressive myeloid populations and induce inflammation in the tumor microenvironment, leading to suppression of tumor growth

Free
Ani Nguyen, Jessica Ritter, Mohammad Zafari, Denise Manfra, Veronica Komoroski, Brian O'Nuallain, Ryan Phennicie, Kevin Kauffman, Dominika Nowakowska, Joe Wahle, Steve Sazinsky, Michael Brehm, Igor Feldman, Tatiana Novobrantseva
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P107.
https://doi.org/10.1158/1535-7163.TARG-21-P107
Published: 01 December 2021
View articletitled, Abstract P107: PSGL-1 blocking antibodies repolarize tumor associated macrophages, reduce suppressive myeloid populations and induce inflammation in the tumor microenvironment, leading to suppression of tumor growth
Journal Articles

EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL

Free
Dorothy Brach, Danielle Johnston-Blackwell, Allison Drew, Trupti Lingaraj, Vinny Motwani, Natalie M. Warholic, Igor Feldman, Christopher Plescia, Jesse J. Smith, Robert A. Copeland, Heike Keilhack, Elayne Chan-Penebre, Sarah K. Knutson, Scott A. Ribich, Alejandra Raimondi, Michael J. Thomenius
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2017) 16 (11): 2586–2597.
https://doi.org/10.1158/1535-7163.MCT-16-0840
Published: 01 November 2017
View articletitled, EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL
Open the PDF for EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL in another window
Includes: Supplementary data
Journal Articles

Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models

Free
Elayne Chan-Penebre, Kelli Armstrong, Allison Drew, Alexandra R. Grassian, Igor Feldman, Sarah K. Knutson, Kristy Kuplast-Barr, Maria Roche, John Campbell, Peter Ho, Robert A. Copeland, Richard Chesworth, Jesse J. Smith, Heike Keilhack, Scott A. Ribich
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2017) 16 (5): 850–860.
https://doi.org/10.1158/1535-7163.MCT-16-0678
Published: 02 May 2017
View articletitled, Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models
Open the PDF for Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models in another window
Includes: Supplementary data
Journal Articles

An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies

Free
Jennifer O'Neil, Yair Benita, Igor Feldman, Melissa Chenard, Brian Roberts, Yaping Liu, Jing Li, Astrid Kral, Serguei Lejnine, Andrey Loboda, William Arthur, Razvan Cristescu, Brian B. Haines, Christopher Winter, Theresa Zhang, Andrew Bloecher, Stuart D. Shumway
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (6): 1155–1162.
https://doi.org/10.1158/1535-7163.MCT-15-0843
Published: 02 June 2016
View articletitled, An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies
Open the PDF for An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies in another window
Includes: Supplementary data
Journal Articles

Abstract B78: CRISPR pooled screening identifies differential dependencies on epigenetic pathways

Free
Alexandra R. Grassian, Julian Fowler, Igor Feldman, Thomas Riera, Darren Harvey, Allison E. Drew, Richard Chesworth, Robert A. Copeland, Heike Keilhack, Jesse J. Smith, Scott Ribich
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): B78.
https://doi.org/10.1158/1535-7163.TARG-15-B78
Published: 01 December 2015
View articletitled, Abstract B78: CRISPR pooled screening identifies differential dependencies on epigenetic pathways
Journal Articles

Preclinical Evaluation of the WEE1 Inhibitor MK-1775 as Single-Agent Anticancer Therapy

Free
Amy D. Guertin, Jing Li, Yaping Liu, Melissa S. Hurd, Alwin G. Schuller, Brian Long, Heather A. Hirsch, Igor Feldman, Yair Benita, Carlo Toniatti, Leigh Zawel, Stephen E. Fawell, D. Gary Gilliland, Stuart D. Shumway
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (8): 1442–1452.
https://doi.org/10.1158/1535-7163.MCT-13-0025
Published: 08 August 2013
View articletitled, Preclinical Evaluation of the WEE1 Inhibitor MK-1775 as Single-Agent Anticancer Therapy
Open the PDF for Preclinical Evaluation of the WEE1 Inhibitor MK-1775 as Single-Agent Anticancer Therapy in another window
Includes: Supplementary data