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Igor Astsaturov
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Journal Articles

Conditional Dependency of LP-184 on Prostaglandin Reductase 1 is Synthetic Lethal in Pancreatic Cancers with DNA Damage Repair Deficiencies

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Diana Restifo, Joseph R. McDermott, Dusica Cvetkovic, Troy Dos Santos, Charline Ogier, Aizhan Surumbayeva, Elizabeth A. Handorf, Caleb Schimke, Charlie Ma, Kathy Q. Cai, Anthony J. Olszanski, Umesh Kathad, Kishor Bhatia, Panna Sharma, Aditya Kulkarni, Igor Astsaturov
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (10): 1182–1190.
https://doi.org/10.1158/1535-7163.MCT-22-0818
Published: 02 October 2023
View articletitled, Conditional Dependency of LP-184 on Prostaglandin Reductase 1 is Synthetic Lethal in Pancreatic Cancers with DNA Damage Repair Deficiencies
Open the PDF for Conditional Dependency of LP-184 on Prostaglandin Reductase 1 is Synthetic Lethal in Pancreatic Cancers with DNA Damage Repair Deficiencies in another window
Includes: Supplementary data
Journal Articles

EGFR and RB1 as Dual Biomarkers in HPV-Negative Head and Neck Cancer

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Tim N. Beck, Rachel Georgopoulos, Elena I. Shagisultanova, David Sarcu, Elizabeth A. Handorf, Cara Dubyk, Miriam N. Lango, John A. Ridge, Igor Astsaturov, Ilya G. Serebriiskii, Barbara A. Burtness, Ranee Mehra, Erica A. Golemis
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2016) 15 (10): 2486–2497.
https://doi.org/10.1158/1535-7163.MCT-16-0243
Published: 02 October 2016
View articletitled, EGFR and RB1 as Dual Biomarkers in HPV-Negative Head and Neck Cancer
Open the PDF for EGFR and RB1 as Dual Biomarkers in HPV-Negative Head and Neck Cancer in another window
Includes: Supplementary data
Journal Articles

HSP90 Inhibitor–SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors

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David A. Proia, Donald L. Smith, Junyi Zhang, John-Paul Jimenez, Jim Sang, Luisa Shin Ogawa, Manuel Sequeira, Jaime Acquaviva, Suqin He, Chaohua Zhang, Vladimir Khazak, Igor Astsaturov, Takayo Inoue, Noriaki Tatsuta, Sami Osman, Richard C. Bates, Dinesh Chimmanamada, Weiwen Ying
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2015) 14 (11): 2422–2432.
https://doi.org/10.1158/1535-7163.MCT-15-0455
Published: 03 November 2015
View articletitled, HSP90 Inhibitor–SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors
Open the PDF for HSP90 Inhibitor–SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract B57: Bosutinib and bosutinib-isomer are novel Chk1 and Wee1 kinase inhibitors that sensitize cells to DNA damaging agent by overriding cell cycle checkpoint arrest.

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Neil Beeharry, Eugenia Banina, Vladmir Khazak, Sean Deacon, Jeff Peterson, Mark Andrake, Igor Astsaturov, Tim J. Yen
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): B57.
https://doi.org/10.1158/1535-7163.TARG-13-B57
Published: 01 November 2013
View articletitled, Abstract B57: Bosutinib and bosutinib-isomer are novel Chk1 and Wee1 kinase inhibitors that sensitize cells to DNA damaging agent by overriding cell cycle checkpoint arrest.