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Haihong Zhong
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Journal Articles

Redundant Signaling as the Predominant Mechanism for Resistance to Antibodies Targeting the Type-I Insulin-Like Growth Factor Receptor in Cells Derived from Childhood Sarcoma

Terry J. Shackleford, Seethalakshmi Hariharan, Angelina V. Vaseva, Karina Alagoa, Maricruz Espinoza, Hemant K. Bid, Fuyang Li, Haihong Zhong, Doris A. Phelps, Ryan D. Roberts, Hakan Cam, Cheryl A. London, Denis C. Guttridge, Yidong Chen, Manjeet Rao, Yuzuru Shiio, Peter J. Houghton
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (4): 539–550.
https://doi.org/10.1158/1535-7163.MCT-20-0625
Published: 03 April 2023
View article titled, Redundant Signaling as the Predominant Mechanism for Resistance to Antibodies Targeting the Type-I Insulin-Like Growth Factor Receptor in Cells Derived from Childhood Sarcoma
Open the PDF for Redundant Signaling as the Predominant Mechanism for Resistance to Antibodies Targeting the Type-I Insulin-Like Growth Factor Receptor in Cells Derived from Childhood Sarcoma in another window
Includes: Supplementary data
Journal Articles

Improved Therapeutic Window in BRCA-mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition

Haihong Zhong, Cui Chen, Ravinder Tammali, Shannon Breen, Jing Zhang, Christine Fazenbaker, Maureen Kennedy, James Conway, Brandon W. Higgs, Nicholas Holoweckyj, Rajiv Raja, Jay Harper, Andrew J. Pierce, Ronald Herbst, David A. Tice
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2019) 18 (1): 89–99.
https://doi.org/10.1158/1535-7163.MCT-18-0314
Published: 02 January 2019
View article titled, Improved Therapeutic Window in <em>BRCA</em>-mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition
Open the PDF for Improved Therapeutic Window in <em>BRCA</em>-mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition in another window
Includes: Supplementary data
Journal Articles

Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody–Drug Conjugate Targeting 5T4

Jay Harper, Christopher Lloyd, Nazzareno Dimasi, Dorin Toader, Rose Marwood, Leeanne Lewis, David Bannister, Jelena Jovanovic, Ryan Fleming, Francois D'Hooge, Shenlan Mao, Allison M. Marrero, Martin Korade, III, Patrick Strout, Linda Xu, Cui Chen, Leslie Wetzel, Shannon Breen, Lilian van Vlerken-Ysla, Sanjoo Jalla, Marlon Rebelatto, Haihong Zhong, Elaine M. Hurt, Mary Jane Hinrichs, Keven Huang, Philip W. Howard, David A. Tice, Robert E. Hollingsworth, Ronald Herbst, Adeela Kamal
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2017) 16 (8): 1576–1587.
https://doi.org/10.1158/1535-7163.MCT-16-0825
Published: 02 August 2017
View article titled, Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody–Drug Conjugate Targeting 5T4
Open the PDF for Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody–Drug Conjugate Targeting 5T4 in another window
Includes: Supplementary data
Journal Articles

MEDI-573, Alone or in Combination with Mammalian Target of Rapamycin Inhibitors, Targets the Insulin-like Growth Factor Pathway in Sarcomas

Haihong Zhong, Christine Fazenbaker, Shannon Breen, Cui Chen, Jiaqi Huang, Christopher Morehouse, Yihong Yao, Robert E. Hollingsworth
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2014) 13 (11): 2662–2673.
https://doi.org/10.1158/1535-7163.MCT-14-0144
Published: 03 November 2014
View article titled, MEDI-573, Alone or in Combination with Mammalian Target of Rapamycin Inhibitors, Targets the Insulin-like Growth Factor Pathway in Sarcomas
Open the PDF for MEDI-573, Alone or in Combination with Mammalian Target of Rapamycin Inhibitors, Targets the Insulin-like Growth Factor Pathway in Sarcomas in another window
Includes: Supplementary data