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Guido J.R. Zaman
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Journal Articles

Abstract A100: Large-scale cell line profiling of small molecule MAPK pathway inhibitors identifies important differences between therapeutics acting on the same biochemical target

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Jeffrey J. Kooijman, Awan Al Koerdi, Wilhelmina E. van Riel, Esmee van den Bossche, Jelle Dylus, Jeroen A.D.M. de Roos, Janneke J.T.M. Melis, Guido J.R. Zaman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): A100.
https://doi.org/10.1158/1535-7163.TARG-23-A100
Published: 01 December 2023
View article titled, Abstract A100: Large-scale cell line profiling of small molecule MAPK pathway inhibitors identifies important differences between therapeutics acting on the same biochemical target
Journal Articles

Abstract B061: Sensitivity and resistance mechanisms of human cancer cell lines treated with PARP, POLθ, and ATR inhibitor combinations in 2D and 3D spheroid cell viability assays

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Janneke J.T.M. Melis, Jeffrey Kooijman, Sabine Wetemans, Suzan Geerdink-Datema, Jelle Dylus, Jeroen A.D.M. de Roos, Wilhelmina E. van Riel, Guido J.R. Zaman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): B061.
https://doi.org/10.1158/1535-7163.TARG-23-B061
Published: 01 December 2023
View article titled, Abstract B061: Sensitivity and resistance mechanisms of human cancer cell lines treated with PARP, POLθ, and ATR inhibitor combinations in 2D and 3D spheroid cell viability assays
Journal Articles

Abstract A141: Computational models of synergy contribute to efficient combination screening

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Joost C.M. Uitdehaag, Martine B.W. Prinsen, Derek W. van Tilborg, Jeffrey J. Kooijman, Jelle Dylus, Jeroen A.D.M. de Roos, Suzanne J.C. van Gerwen, Jos de Man, Rogier C. Buijsman, Guido J.R. Zaman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): A141.
https://doi.org/10.1158/1535-7163.TARG-19-A141
Published: 01 December 2019
View article titled, Abstract A141: Computational models of synergy contribute to efficient combination screening
Journal Articles

Abstract B060: Side-by-side comparison of small molecule IDO1 inhibitors in biochemical and cell-based assays and development of a IDO1-expressing mouse model to evaluate target modulation

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Yvonne Grobben, Joost C.M. Uitdehaag, Antoon M. van Doornmalen, Nicole Willemsen-Seegers, Diep Vu-Pham, Jos de Man, Rogier C. Buijsman, Guido J.R. Zaman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): B060.
https://doi.org/10.1158/1535-7163.TARG-19-B060
Published: 01 December 2019
View article titled, Abstract B060: Side-by-side comparison of small molecule IDO1 inhibitors in biochemical and cell-based assays and development of a IDO1-expressing mouse model to evaluate target modulation
Journal Articles

Abstract A044: A precision medicine platform to predict the clinical response to chemo- and immunotherapy for epithelial ovarian cancer

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Guido J.R. Zaman, Judith E. den Ouden, Jelle Dylus, Antoon M. van Doornmalen, Winfried R. Mulder, Diep Vu-Pham, Suzanne J.C. van Gerwen, Joost C.M. Uitdehaag, Rogier C. Buijsman, Leon F. Massuger, Anne M. van Altena
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): A044.
https://doi.org/10.1158/1535-7163.TARG-19-A044
Published: 01 December 2019
View article titled, Abstract A044: A precision medicine platform to predict the clinical response to chemo- and immunotherapy for epithelial ovarian cancer
Journal Articles

Combined Cellular and Biochemical Profiling to Identify Predictive Drug Response Biomarkers for Kinase Inhibitors Approved for Clinical Use between 2013 and 2017

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Joost C.M. Uitdehaag, Jeffrey J. Kooijman, Jeroen A.D.M. de Roos, Martine B.W. Prinsen, Jelle Dylus, Nicole Willemsen-Seegers, Yusuke Kawase, Masaaki Sawa, Jos de Man, Suzanne J.C. van Gerwen, Rogier C. Buijsman, Guido J.R. Zaman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (2): 470–481.
https://doi.org/10.1158/1535-7163.MCT-18-0877
Published: 04 February 2019
View article titled, Combined Cellular and Biochemical Profiling to Identify Predictive Drug Response Biomarkers for Kinase Inhibitors Approved for Clinical Use between 2013 and 2017
Open the PDF for Combined Cellular and Biochemical Profiling to Identify Predictive Drug Response Biomarkers for Kinase Inhibitors Approved for Clinical Use between 2013 and 2017 in another window
Includes: Supplementary data
Journal Articles

Abstract B155: Combining cell panel screening with analysis of gene expression levels reveals features of drug response and resistance

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Joost C.M. Uitdehaag, Jeffrey Kooijman, Jeroen A.D.M. de Roos, Martine B.W. Prinsen, Jelle Dylus, Suzanne J.C. van Gerwen, Rogier C. Buijsman, Guido J.R. Zaman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): B155.
https://doi.org/10.1158/1535-7163.TARG-17-B155
Published: 01 January 2018
View article titled, Abstract B155: Combining cell panel screening with analysis of gene expression levels reveals features of drug response and resistance
Journal Articles

TTK Inhibitors as a Targeted Therapy for CTNNB1 ( β -catenin) Mutant Cancers

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Guido J.R. Zaman, Jeroen A.D.M. de Roos, Marion A.A. Libouban, Martine B.W. Prinsen, Jos de Man, Rogier C. Buijsman, Joost C.M. Uitdehaag
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (11): 2609–2617.
https://doi.org/10.1158/1535-7163.MCT-17-0342
Published: 01 November 2017
View article titled, TTK Inhibitors as a Targeted Therapy for CTNNB1 ( β -catenin) Mutant Cancers
Open the PDF for TTK Inhibitors as a Targeted Therapy for CTNNB1 ( β -catenin) Mutant Cancers in another window
Includes: Supplementary data
Journal Articles

Cell Panel Profiling Reveals Conserved Therapeutic Clusters and Differentiates the Mechanism of Action of Different PI3K/mTOR, Aurora Kinase and EZH2 Inhibitors

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Joost C.M. Uitdehaag, Jeroen A.D.M. de Roos, Martine B.W. Prinsen, Nicole Willemsen-Seegers, Judith R.F. de Vetter, Jelle Dylus, Antoon M. van Doornmalen, Jeffrey Kooijman, Masaaki Sawa, Suzanne J.C. van Gerwen, Jos de Man, Rogier C. Buijsman, Guido J.R. Zaman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (12): 3097–3109.
https://doi.org/10.1158/1535-7163.MCT-16-0403
Published: 01 December 2016
View article titled, Cell Panel Profiling Reveals Conserved Therapeutic Clusters and Differentiates the Mechanism of Action of Different PI3K/mTOR, Aurora Kinase and EZH2 Inhibitors
Open the PDF for Cell Panel Profiling Reveals Conserved Therapeutic Clusters and Differentiates the Mechanism of Action of Different PI3K/mTOR, Aurora Kinase and EZH2 Inhibitors in another window
Includes: Supplementary data