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Gerald S. Falchook
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Journal Articles

Abstract P06-03: ST101, a peptide targeting oncogenic transcription factor C/EBPβ: initial safety, efficacy, pharmacokinetic (PK) and pharmacodynamic (PD) data from an ongoing phase 1 dose escalation study in patients with advanced, metastatic solid tumors

Nehal J. Lakhani, Hendrik-Tobias Arkenau, Stefan N. Symeonides, Jeffry Evans, Meredith A. McKean, Elisa Fontana, Manojkumar Bupath, Alistair McLaren, Sreenivasa Chandana, Tze-en Ding, Emerson A. Lim, Jim Rotolo, Gina Capiaux, Rob Michel, Stephen Kaesshaefer, Alice S. Bexon, Gerald S. Falchook
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P06-03.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P06-03
Published: 01 December 2021
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Abstract P044: A phase 1 dose escalation study of protein arginine methyltransferase 5 (PRMT5) brain penetrant inhibitor PRT811 in patients with advanced solid tumors, including recurrent high-grade gliomas

Gerald S. Falchook, Jon Glass, Varun Monga, Pierre Giglio, David Mauro, John Viscusi, Peggy Scherle, Neha Bhagwat, William Sun, Rachel Chiaverelli, Eric Mintah, Lydia Clements, Tanner M. Johanns, Meredith McKean
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P044.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P044
Published: 01 December 2021
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Journal Articles

Phase I Dose-Escalation Study of Anti–CTLA-4 Antibody Ipilimumab and Lenalidomide in Patients with Advanced Cancers

Divya Sakamuri, Isabella C. Glitza, Sonia L. Betancourt Cuellar, Vivek Subbiah, Siqing Fu, Apostolia M. Tsimberidou, Jennifer J. Wheler, David S. Hong, Aung Naing, Gerald S. Falchook, Michelle A. Fanale, Maria E. Cabanillas, Filip Janku
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (3): 671–676.
DOI: https://doi.org/10.1158/1535-7163.MCT-17-0673
Published: 28 February 2018
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TP53 Alterations Correlate with Response to VEGF/VEGFR Inhibitors: Implications for Targeted Therapeutics

Jennifer J. Wheler, Filip Janku, Aung Naing, Yali Li, Bettzy Stephen, Ralph Zinner, Vivek Subbiah, Siqing Fu, Daniel Karp, Gerald S. Falchook, Apostolia M. Tsimberidou, Sarina Piha-Paul, Roosevelt Anderson, Danxia Ke, Vincent Miller, Roman Yelensky, J. Jack Lee, David Hong, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2016) 15 (10): 2475–2485.
DOI: https://doi.org/10.1158/1535-7163.MCT-16-0196
Published: 02 October 2016
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Includes: Supplementary data
Journal Articles

BRAF Mutation Testing in Cell-Free DNA from the Plasma of Patients with Advanced Cancers Using a Rapid, Automated Molecular Diagnostics System

Filip Janku, Helen J. Huang, Bart Claes, Gerald S. Falchook, Siqing Fu, David Hong, Nishma M. Ramzanali, Giovanni Nitti, Goran Cabrilo, Apostolia M. Tsimberidou, Aung Naing, Sarina A. Piha-Paul, Jennifer J. Wheler, Daniel D. Karp, Veronica R. Holley, Ralph G. Zinner, Vivek Subbiah, Rajyalakshmi Luthra, Scott Kopetz, Michael J. Overman, Bryan K. Kee, Sapna Patel, Benoit Devogelaere, Erwin Sablon, Geert Maertens, Gordon B. Mills, Razelle Kurzrock, Funda Meric-Bernstam
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (6): 1397–1404.
DOI: https://doi.org/10.1158/1535-7163.MCT-15-0712
Published: 02 June 2016
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Includes: Supplementary data
Journal Articles

Abstract C50: Phase I dose escalation study of the oral multi-kinase VEGF inhibitor regorafenib and the anti-EGFR monoclonal antibody cetuximab in patients with advanced solid tumors including colorectal cancer

Vivek Subbiah, David S. Hong, Behrang Amini, Sarina Piha-Paul, Joanna Grace Fernandez, Siquing Fu, Apostolia M. Tsimberidou, Aung Naing, Filip Janku, Daniel D. Karp, Michael Overman, Cathy Eng, Scott Kopetz, Funda Meric-Bernstam, Gerald S. Falchook
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): C50.
DOI: https://doi.org/10.1158/1535-7163.TARG-15-C50
Published: 01 December 2015
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Journal Articles

Abstract A194: PEGylated human IL-10 (AM0010) in advanced solid tumors

Jeffrey R. Infante, Aung Naing, Kyriakos P. Papadopoulos, Karen A. Autio, Patrick A. Ott, Deborah J. Wong, Gerald S. Falchook, Manish Patel, Shubham Pant, Melinda Whiteside, Johanna C. Bendell, Todd M. Bauer, Filip Janku, Milind Javle, Rivka Colen, Nizar Tannir, Martin Oft
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): A194.
DOI: https://doi.org/10.1158/1535-7163.TARG-15-A194
Published: 01 December 2015
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Journal Articles

Target-Based Therapeutic Matching in Early-Phase Clinical Trials in Patients with Advanced Colorectal Cancer and PIK3CA Mutations

Prasanth Ganesan, Filip Janku, Aung Naing, David S. Hong, Apostolia M. Tsimberidou, Gerald S. Falchook, Jennifer J. Wheler, Sarina A. Piha-Paul, Siqing Fu, Vanda M. Stepanek, J. Jack Lee, Rajyalakshmi Luthra, Michael J. Overman, E. Scott Kopetz, Robert A. Wolff, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (12): 2857–2863.
DOI: https://doi.org/10.1158/1535-7163.MCT-13-0319-T
Published: 05 December 2013
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Includes: Supplementary data
Journal Articles

Abstract C203: BRAF and KRAS mutation testing in cell-free DNA and circulating tumor cells from blood of patients with metastatic cancers.

Filip Janku, Ben Legendre, Katherine Richardson, Gerald S. Falchook, Aung Naing, Veronica R. Holley, David S. Hong, Ralph G. Zinner, Siqing Fu, Apostolia M. Tsimberidou, Vivek Subbiah, Daniel D. Karp, Sarina A. Piha-Paul, Jennifer J. Wheler, Vanda M. Stepanek, Goran Cabrilo, Rajyalakshmi Luthra, Funda Meric-Bernstam, Amy Kruempel, Jaclyn Pope, Courtney Cubrich, Grant Wu, Yanggu Shi, Marcia Lewis, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): C203.
DOI: https://doi.org/10.1158/1535-7163.TARG-13-C203
Published: 01 November 2013
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Abstract A202: BRAF mutation testing in cell-free DNA from plasma of patients with advanced cancers using a novel, rapid, automated molecular diagnostics prototype platform.

Helen J. Huang, Bart Claes, Gerald S. Falchook, Apostolia M. Tsimberidou, Veronica R. Holley, Vivek Subbiah, Ralph G. Zinner, Aung Naing, Daniel D. Karp, Sarina A. Piha-Paul, Jennifer J. Wheler, Siqing Fu, David S. Hong, Vanda M. Stepanek, Rajyalakshmi Luthra, Funda Meric-Bernstam, Tania Ivens, Erwin Sablon, Geert Maertens, Bryan K. Kee, Razelle Kurzrock, Stefan Scherer, Filip Janku
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): A202.
DOI: https://doi.org/10.1158/1535-7163.TARG-13-A202
Published: 01 November 2013
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Abstract B26: Actionable mutations in cell-free DNA in plasma of patients with advanced cancers referred for experimental targeted therapies.

Filip Janku, Philipp Angenendt, Aung Naing, Gerald S. Falchook, Apostolia M. Tsimberidou, Veronica R. Holley, Siqing Fu, David S. Hong, Jennifer J. Wheler, Sarina A. Piha-Paul, Ralph G. Zinner, Daniel D. Karp, Vivek Subbiah, Kevin B. Kim, Funda Meric-Bernstam, Frank Diehl, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): B26.
DOI: https://doi.org/10.1158/1535-7163.TARG-13-B26
Published: 01 November 2013
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Journal Articles

Abstract B82: Olanzapine for cachexia in patients with advanced cancer.

Maen Abdelrahim, Aung Naing, Shalini Dalal, Jennifer Wheler, Kenneth Hess, Siqing Fu, David S. Hong, Filip Janku, Gerald S. Falchook, Alyson Ilustre, Fengying Ouyang, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): B82.
DOI: https://doi.org/10.1158/1535-7163.TARG-13-B82
Published: 01 November 2013
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Abstract C198: BRAF mutation testing of archival tumor samples with a novel, rapid, fully-automated molecular diagnostics prototype platform.

Helen J. Huang, Bart Claes, Gerald S. Falchook, Benoit Devogelaere, Aung Naing, Siqing Fu, Sarina Piha-Paul, David S. Hong, Veronica R. Holley, Apostolia M. Tsimberidou, Vanda M. Stepanek, Kevin B. Kim, Laura S. Angelo, Vivek Subbiah, Jennifer J. Wheler, Ralph G. Zinner, Daniel D. Karp, Rajyalakshmi Luthra, Erwin Sablon, Geert Maertens, Funda Meric-Bernstam, Razelle Kurzrock, Stefan Scherer, Filip Janku
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): C198.
DOI: https://doi.org/10.1158/1535-7163.TARG-13-C198
Published: 01 November 2013
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Journal Articles

Abstract C69: Phase I trial of lenalidomide and valproic acid in patients with advanced cancer.

Mehmet A. Bilen, Siqing Fu, David S. Hong, Jennifer J. Wheler, Maen Abdelrahim, Gerald S. Falchook, Apostlia M. Tsimberidou, Filip Janku, Sarina Piha-Paul, Ralph Zinner, Razelle Kurzrock, Aung Naing
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): C69.
DOI: https://doi.org/10.1158/1535-7163.TARG-13-C69
Published: 01 November 2013
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Abstract B175: Detection and monitoring of BRAF and KRAS mutations in cell-free urinary DNA of metastatic cancer patients by droplet digital PCR.

Filip Janku, Gerald S. Falchook, Sarina A. Piha-Paul, Aung Naing, Apostolia M. Tsimberidou, Veronica R. Holley, Daniel D. Karp, Ralph G. Zinner, Siqing Fu, Jennifer J. Wheler, David S. Hong, Funda Meric-Bernstam, Vanda M. Stepanek, Rayjalakshmi Luthra, Lorieta Leppin, Latifa Hassaine, Karena Kosco, Jason C. Poole, Mark G. Erlander
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): B175.
DOI: https://doi.org/10.1158/1535-7163.TARG-13-B175
Published: 01 November 2013
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Journal Articles

Combining Erlotinib and Cetuximab Is Associated with Activity in Patients with Non–Small Cell Lung Cancer (Including Squamous Cell Carcinomas) and Wild-Type EGFR or Resistant Mutations

Jennifer J. Wheler, Apostolia M. Tsimberidou, Gerald S. Falchook, Ralph G. Zinner, David S. Hong, Jansina Y. Fok, Siqing Fu, Sarina A. Piha-Paul, Aung Naing, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (10): 2167–2175.
DOI: https://doi.org/10.1158/1535-7163.MCT-12-1208
Published: 07 October 2013
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Abstract B194: Phase 1 relative bioavailability study of a prototype oral solution (OS) formulation of the investigational Aurora A kinase (AAK) inhibitor alisertib (MLN8237) in reference to a powder-in-capsule (PIC) formulation in patients with advanced solid tumors.

Gerald S. Falchook, John Sarantopoulos, Razelle Kurzrock, Alain C. Mita, Siqing Fu, Monica M. Mita, Xiaofei Zhou, Catherine Milch, JungAh Jung, Karthik Venkatakrishnan, Lee S. Rosen
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): B194.
DOI: https://doi.org/10.1158/1535-7163.TARG-11-B194
Published: 12 November 2011
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Abstract A95: The determination of the maximum tolerated dose (MTD) of MGCD265 on an intermittent schedule: Phase I study results (Study 265-102).

Jennifer Wheler, Razelle Kurzrock, Elizabeth I. Heath, Gerald S. Falchook, Christiane R. Maroun, Michel A. Drouin, Manuela Juretic, Claire Bonfils, Andre Karam, Jeffrey M. Besterman, James Wang, Patricia LoRusso
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): A95.
DOI: https://doi.org/10.1158/1535-7163.TARG-11-A95
Published: 12 November 2011
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Abstract B56: A phase 1, open-label, dose escalation, nonrandomized study to assess the maximum tolerated dose, dose limiting toxicity, and pharmacokinetics of OPB-31121 in subjects with advanced solid tumors.

Razelle Kurzrock, Aung Naing, Gerald S. Falchook, David S. Hong, Agnes Elekes, Takumi Sumida, Patricia Bricmont, Takeshi Kodama, Masaaki Motoyama, Shiva Patil, Jennifer Lee, Suzanne Jones, Jeffrey Infante, Howard Burris, Johanna Bendell
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): B56.
DOI: https://doi.org/10.1158/1535-7163.TARG-11-B56
Published: 12 November 2011
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Abstract A211: A phase I study of MABp1, a first-in-human, first-true human monoclonal antibody against the IL-1 in patients with advanced cancers.

David S. Hong, Aung Naing, Gerald S. Falchook, Sarina Piha-PAul, Jennifer J. Wheler, Siqing Fu, Apostolia M. Tsimberidou, David Hui, Rebecca Scott, Rabia Khan, Reena Mistry, Julia Talley, Seema Chauhan, Derrick Bermudez, Michael Stecher, John Simard, Razelle Kurzrock
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): A211.
DOI: https://doi.org/10.1158/1535-7163.TARG-11-A211
Published: 12 November 2011
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