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Gail D. Lewis
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Journal Articles

Site-Specific Dolasynthen Antibody–Drug Conjugates Exhibit Consistent Pharmacokinetic Profiles across a Wide Range of Drug-to-Antibody Ratios

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Susan M. Clardy, Alex Uttard, Bingfan Du, Kalli C. Catcott, Kelly L. Lancaster, Elizabeth Ditty, Jack Sadowsky, Jeffrey Zurita, Naniye Malli, LiuLiang Qin, Stephen P. Bradley, Kenneth Avocetien, Tyler Carter, Dokyong Kim, Mark Nazzaro, Ling Xu, Thomas H. Pillow, Neelie T. Zacharias, Gail D. Lewis, Rebecca K. Rowntree, Radha Iyengar, David H. Lee, Marc Damelin, Dorin Toader, Timothy B. Lowinger
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2024) 23 (1): 84–91.
https://doi.org/10.1158/1535-7163.MCT-23-0262
Published: 03 January 2024
View articletitled, Site-Specific Dolasynthen Antibody–Drug Conjugates Exhibit Consistent Pharmacokinetic Profiles across a Wide Range of Drug-to-Antibody Ratios
Open the PDF for Site-Specific Dolasynthen Antibody–Drug Conjugates Exhibit Consistent Pharmacokinetic Profiles across a Wide Range of Drug-to-Antibody Ratios in another window
Includes: Supplementary data
Journal Articles

Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells

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Guangmin Li, Jun Guo, Ben-Quan Shen, Daniela Bumbaca Yadav, Mark X. Sliwkowski, Lisa M. Crocker, Jennifer A. Lacap, Gail D. Lewis Phillips
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2018) 17 (7): 1441–1453.
https://doi.org/10.1158/1535-7163.MCT-17-0296
Published: 01 July 2018
View articletitled, Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells
Open the PDF for Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells in another window
Includes: Supplementary data
Journal Articles

The Effect of Different Linkers on Target Cell Catabolism and Pharmacokinetics/Pharmacodynamics of Trastuzumab Maytansinoid Conjugates

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Hans K. Erickson, Gail D. Lewis Phillips, Douglas D. Leipold, Carmela A. Provenzano, Elaine Mai, Holly A. Johnson, Bert Gunter, Charlene A. Audette, Manish Gupta, Jan Pinkas, Jay Tibbitts
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (5): 1133–1142.
https://doi.org/10.1158/1535-7163.MCT-11-0727
Published: 08 May 2012
View articletitled, The Effect of Different Linkers on Target Cell Catabolism and Pharmacokinetics/Pharmacodynamics of Trastuzumab Maytansinoid Conjugates
Open the PDF for The Effect of Different Linkers on Target Cell Catabolism and Pharmacokinetics/Pharmacodynamics of Trastuzumab Maytansinoid Conjugates in another window
Includes: Supplementary data
Journal Articles

Abstract A149: The effect of linker on target cell catabolism and PK/PD of trastuzumab maytansinoid conjugates

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Hans Erickson, Gail D. Lewis Phillips, Carmela Provenzano, Douglas D. Leipold, Holly Johnson, Elaine Mai, Charlene Audette, Kirsten Messick, Jan Pinkas, Manish Gupta, Jay Tibbitts
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): A149.
https://doi.org/10.1158/1535-7163.TARG-09-A149
Published: 10 December 2009
View articletitled, Abstract A149: The effect of linker on target cell catabolism and PK/PD of trastuzumab maytansinoid conjugates
Journal Articles

Molecular predictors of response to a humanized anti–insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer

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Jiping Zha, Carol O'Brien, Heidi Savage, Ling-Yuh Huw, Fiona Zhong, Leanne Berry, Gail D. Lewis Phillips, Elizabeth Luis, Guy Cavet, Xiaolan Hu, Lukas C. Amler, Mark R. Lackner
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (8): 2110–2121.
https://doi.org/10.1158/1535-7163.MCT-09-0381
Published: 14 August 2009
View articletitled, Molecular predictors of response to a humanized anti–insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer
Open the PDF for Molecular predictors of response to a humanized anti–insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer in another window
Includes: Supplementary data