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Journal Articles

Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody–Drug Conjugate for the Treatment of Cancer

Dorin Toader, Shawn P. Fessler, Scott D. Collins, Patrick R. Conlon, Reddy Bollu, Kalli C. Catcott, Chen-Ni Chin, Anouk Dirksen, Bingfan Du, Jeremy R. Duvall, Stacy Higgins, Mariya V. Kozytska, Kamela Bellovoda, Chelsey Faircloth, David Lee, Fu Li, Liuliang Qin, Caitlin Routhier, Pamela Shaw, Cheri A. Stevenson, Jason Wang, Phonphimon Wongthida, Elena Ter-Ovanesyan, Elizabeth Ditty, Stephen P. Bradley, Ling Xu, Mao Yin, Alexandr V. Yurkovetskiy, Rebecca Mosher, Marc Damelin, Timothy B. Lowinger
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (9): 999–1012.
https://doi.org/10.1158/1535-7163.MCT-22-0786
Published: 05 September 2023
View article titled, Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody–Drug Conjugate for the Treatment of Cancer
Open the PDF for Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody–Drug Conjugate for the Treatment of Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract LBA008: CS5001, a novel ROR1-targeting antibody drug conjugate (ADC) armed with tumor-cleavable β-glucuronide linkers and pyrrolobenzodiazepine (PBD) prodrugs for hematological and solid malignancies

Fu Li, Yongwang Li, Lan Zhang, Clarence K. Zhang, Hui-Han A. Hu, Juan Zhang, Ying Pan, Jinwon Jung, Sang Hoon Lee, Hyun-Min Ryu, Yun-Hee Park, Haixiang Yu, Archie N. Tse
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): LBA008.
https://doi.org/10.1158/1535-7163.TARG-21-LBA008
Published: 01 December 2021
View article titled, Abstract LBA008: CS5001, a novel ROR1-targeting antibody drug conjugate (ADC) armed with tumor-cleavable β-glucuronide linkers and pyrrolobenzodiazepine (PBD) prodrugs for hematological and solid malignancies
Journal Articles

Mouse Strains Influence Clearance and Efficacy of Antibody and Antibody–Drug Conjugate Via Fc–FcγR Interaction

Fu Li, Michelle L. Ulrich, Vincent Feng-Sheng Shih, Julia H. Cochran, Joshua H. Hunter, Lori Westendorf, Jason Neale, Dennis R. Benjamin
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2019) 18 (4): 780–787.
https://doi.org/10.1158/1535-7163.MCT-18-0977
Published: 01 April 2019
View article titled, Mouse Strains Influence Clearance and Efficacy of Antibody and Antibody–Drug Conjugate Via Fc–FcγR Interaction
Open the PDF for Mouse Strains Influence Clearance and Efficacy of Antibody and Antibody–Drug Conjugate Via Fc–FcγR Interaction in another window
Includes: Supplementary data
Journal Articles

Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody–Drug Conjugates

Christopher S. Neumann, Kathleen C. Olivas, Martha E. Anderson, Julia H. Cochran, Steven Jin, Fu Li, Luke V. Loftus, David W. Meyer, Jason Neale, Jay C. Nix, Paul G. Pittman, Jessica K. Simmons, Michelle L. Ulrich, Andrew B. Waight, Abbie Wong, Margo C. Zaval, Weiping Zeng, Robert P. Lyon, Peter D. Senter
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2018) 17 (12): 2633–2642.
https://doi.org/10.1158/1535-7163.MCT-18-0643
Published: 03 December 2018
View article titled, Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody–Drug Conjugates
Open the PDF for Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody–Drug Conjugates in another window
Includes: Supplementary data
Journal Articles

Characterization of SGN-CD123A, A Potent CD123-Directed Antibody–Drug Conjugate for Acute Myeloid Leukemia

Fu Li, May Kung Sutherland, Changpu Yu, Roland B. Walter, Lori Westendorf, John Valliere-Douglass, Lucy Pan, Ashley Cronkite, Django Sussman, Kerry Klussman, Michelle Ulrich, Martha E. Anderson, Ivan J. Stone, Weiping Zeng, Mechthild Jonas, Timothy S. Lewis, Maitrayee Goswami, Sa A. Wang, Peter D. Senter, Che-Leung Law, Eric J. Feldman, Dennis R. Benjamin
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2018) 17 (2): 554–564.
https://doi.org/10.1158/1535-7163.MCT-17-0742
Published: 01 February 2018
View article titled, Characterization of SGN-CD123A, A Potent CD123-Directed Antibody–Drug Conjugate for Acute Myeloid Leukemia
Open the PDF for Characterization of SGN-CD123A, A Potent CD123-Directed Antibody–Drug Conjugate for Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Tumor-Associated Macrophages Can Contribute to Antitumor Activity through FcγR-Mediated Processing of Antibody–Drug Conjugates

Fu Li, Michelle Ulrich, Mechthild Jonas, Ivan J. Stone, Germein Linares, Xinqun Zhang, Lori Westendorf, Dennis R. Benjamin, Che-Leung Law
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (7): 1347–1354.
https://doi.org/10.1158/1535-7163.MCT-17-0019
Published: 04 July 2017
View article titled, Tumor-Associated Macrophages Can Contribute to Antitumor Activity through FcγR-Mediated Processing of Antibody–Drug Conjugates
Open the PDF for Tumor-Associated Macrophages Can Contribute to Antitumor Activity through FcγR-Mediated Processing of Antibody–Drug Conjugates in another window
Includes: Supplementary data