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Enrique Rozengurt
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Journal Articles

Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy

Open Access
James Sinnett-Smith, Tarique Anwar, Elaine F. Reed, Yaroslav Teper, Guido Eibl, Enrique Rozengurt
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (11): 1652–1662.
https://doi.org/10.1158/1535-7163.MCT-21-0964
Published: 03 November 2022
View articletitled, Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy
Open the PDF for Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy in another window
Includes: Supplementary data
Journal Articles

Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2

Free
Heloisa P. Soares, Ming Ming, Michelle Mellon, Steven H. Young, Liang Han, James Sinnet-Smith, Enrique Rozengurt
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (4): 1014–1023.
https://doi.org/10.1158/1535-7163.MCT-14-0669
Published: 09 April 2015
View articletitled, Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2
Open the PDF for Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2 in another window
Includes: Supplementary data
Journal Articles

Suppression of Feedback Loops Mediated by PI3K/mTOR Induces Multiple Overactivation of Compensatory Pathways: An Unintended Consequence Leading to Drug Resistance

Free
Enrique Rozengurt, Heloisa P. Soares, James Sinnet-Smith
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2014) 13 (11): 2477–2488.
https://doi.org/10.1158/1535-7163.MCT-14-0330
Published: 03 November 2014
View articletitled, Suppression of Feedback Loops Mediated by PI3K/mTOR Induces Multiple Overactivation of Compensatory Pathways: An Unintended Consequence Leading to Drug Resistance
Open the PDF for Suppression of Feedback Loops Mediated by PI3K/mTOR Induces Multiple Overactivation of Compensatory Pathways: An Unintended Consequence Leading to Drug Resistance in another window
Journal Articles

A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In vitro and In vivo

Free
Kuzhuvelil B. Harikumar, Ajaikumar B. Kunnumakkara, Nobuo Ochi, Zhimin Tong, Amit Deorukhkar, Bokyung Sung, Lloyd Kelland, Stephen Jamieson, Rachel Sutherland, Tony Raynham, Mark Charles, Azadeh Bagherzadeh, Caroline Foxton, Alexandra Boakes, Muddasar Farooq, Dipen Maru, Parmeswaran Diagaradjane, Yoichi Matsuo, James Sinnett-Smith, Juri Gelovani, Sunil Krishnan, Bharat B. Aggarwal, Enrique Rozengurt, Christopher R. Ireson, Sushovan Guha
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (5): 1136–1146.
https://doi.org/10.1158/1535-7163.MCT-09-1145
Published: 09 May 2010
View articletitled, A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In vitro and In vivo
Open the PDF for A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In vitro and In vivo in another window
Includes: Supplementary data