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Douglas D. Leipold
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Journal Articles

Novel Anti-LY6G6D/CD3 T-Cell–Dependent Bispecific Antibody for the Treatment of Colorectal Cancer

Open Access
Peiyin Wang, Liping L. Sun, Robyn Clark, Maria Hristopoulos, Cecilia P.C. Chiu, Michael Dillon, WeiYu Lin, Amy A. Lo, Sreedevi Chalsani, Meghna Das Thakur, Kristin M. Zimmerman Savill, Lionel Rougé, Patrick Lupardus, Robert Piskol, Bushra Husain, Diego Ellerman, Vittal Shivva, Steven R. Leong, Meric Ovacik, Klara Totpal, Yan Wu, Christoph Spiess, Genee Lee, Douglas D. Leipold, Andrew G. Polson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (6): 974–985.
https://doi.org/10.1158/1535-7163.MCT-21-0599
Published: 01 June 2022
View articletitled, Novel Anti-LY6G6D/CD3 T-Cell–Dependent Bispecific Antibody for the Treatment of Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Calicheamicin Antibody–Drug Conjugates with Improved Properties

Available to Purchase
Breanna S. Vollmar, Chris Frantz, Melissa M. Schutten, Fiona Zhong, Geoffrey del Rosario, Mary Ann T. Go, Shang-Fan Yu, Douglas D. Leipold, Amrita V. Kamath, Carl Ng, Keyang Xu, Josefa dela Cruz-Chuh, Katherine R. Kozak, Jinhua Chen, Zijin Xu, John Wai, Pragya Adhikari, Hans K. Erickson, Peter S. Dragovich, Andrew G. Polson, Thomas H. Pillow
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (6): 1112–1120.
https://doi.org/10.1158/1535-7163.MCT-20-0035
Published: 01 June 2021
View articletitled, Calicheamicin Antibody–Drug Conjugates with Improved Properties
Open the PDF for Calicheamicin Antibody–Drug Conjugates with Improved Properties in another window
Includes: Supplementary data
Journal Articles

Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody–Drug Conjugates with Self-Immolative Disulfide Linkers

Free
Thomas H. Pillow, Melissa Schutten, Shang-Fan Yu, Rachana Ohri, Jack Sadowsky, Kirsten Achilles Poon, Willy Solis, Fiona Zhong, Geoffrey Del Rosario, Mary Ann T. Go, Jeffrey Lau, Sharon Yee, Jintang He, Luna Liu, Carl Ng, Keyang Xu, Douglas D. Leipold, Amrita V. Kamath, Donglu Zhang, Luke Masterson, Stephen J. Gregson, Philip W. Howard, Fan Fang, Jinhua Chen, Janet Gunzner-Toste, Katherine K. Kozak, Susan Spencer, Paul Polakis, Andrew G. Polson, John A. Flygare, Jagath R. Junutula
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (5): 871–878.
https://doi.org/10.1158/1535-7163.MCT-16-0641
Published: 02 May 2017
View articletitled, Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody–Drug Conjugates with Self-Immolative Disulfide Linkers
Open the PDF for Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody–Drug Conjugates with Self-Immolative Disulfide Linkers in another window
Includes: Supplementary data
Journal Articles

The Effect of Different Linkers on Target Cell Catabolism and Pharmacokinetics/Pharmacodynamics of Trastuzumab Maytansinoid Conjugates

Free
Hans K. Erickson, Gail D. Lewis Phillips, Douglas D. Leipold, Carmela A. Provenzano, Elaine Mai, Holly A. Johnson, Bert Gunter, Charlene A. Audette, Manish Gupta, Jan Pinkas, Jay Tibbitts
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (5): 1133–1142.
https://doi.org/10.1158/1535-7163.MCT-11-0727
Published: 08 May 2012
View articletitled, The Effect of Different Linkers on Target Cell Catabolism and Pharmacokinetics/Pharmacodynamics of Trastuzumab Maytansinoid Conjugates
Open the PDF for The Effect of Different Linkers on Target Cell Catabolism and Pharmacokinetics/Pharmacodynamics of Trastuzumab Maytansinoid Conjugates in another window
Includes: Supplementary data
Journal Articles

Abstract A149: The effect of linker on target cell catabolism and PK/PD of trastuzumab maytansinoid conjugates

Free
Hans Erickson, Gail D. Lewis Phillips, Carmela Provenzano, Douglas D. Leipold, Holly Johnson, Elaine Mai, Charlene Audette, Kirsten Messick, Jan Pinkas, Manish Gupta, Jay Tibbitts
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): A149.
https://doi.org/10.1158/1535-7163.TARG-09-A149
Published: 10 December 2009
View articletitled, Abstract A149: The effect of linker on target cell catabolism and PK/PD of trastuzumab maytansinoid conjugates