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David Stokoe
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Journal Articles

Abstract B017: Loss of UXS1 selectively kills KEAP1 mutant cancer cell lines by depleting pyrimidines and inducing replication stress

Timothy Hoffman, Melat Gebru, Aaron Boudreau, Fei Han, Kelly Foster-Duke, Jessica Gajda, Ngoc Vu, Bryson Bennett, Michael Kort, Brad Shotwell, Jonathan Hickson, Noel Wilsomn, David Stokoe
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2024) 23 (6_Supplement): B017.
https://doi.org/10.1158/1538-8514.SYNTHLETH24-B017
Published: 10 June 2024
View article titled, Abstract B017: Loss of UXS1 selectively kills KEAP1 mutant cancer cell lines by depleting pyrimidines and inducing replication stress
Journal Articles

Abstract C022: Large scale phenotypic screening using PRISM, integrated with functional genomic screening and transcriptional profiling accelerates target identification of cytotoxic small molecules

Kevin Larpenteur, Lucian de Waal, Li Wang, Mustafa Kocak, Jordan Bryan, Samantha Bender, Sulyman Barkho, Matt Kukurugya, Amy Goodale, Brenton Paolella, Min Cho, James McFarland, Michael Rothberg, Cong Zhu, Colin Trepiccio, Aviad Tsherniak, David Root, Bryson Bennett, Federica Piccioni, Josh Bittker, James Rong, Christopher Mader, David Stokoe, Ari Firestone, Todd R Golub, Jennifer Roth
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): C022.
https://doi.org/10.1158/1535-7163.TARG-19-C022
Published: 01 December 2019
View article titled, Abstract C022: Large scale phenotypic screening using PRISM, integrated with functional genomic screening and transcriptional profiling accelerates target identification of cytotoxic small molecules
Journal Articles

Abstract B121: An oncogene-linked prodrug strategy in lung cancer

Aaron Boudreau, Jennifer Roth, James Rong, Niclas Olsson, Chris Mader, Jordan Byran, Jordan Rossen, Li Wang, Kevin Larpenteur, Amy Goodale, Colin Trepicchio, Samantha Bender, Aviad Tsherniak, Aravind Subramanian, Mustafa Kocak, Federica Piccioni, Josh Bittker, Cong Zhu, Frank Li, Nick Eriksson, Daphne Koller, Fiona McAllister, Todd Golub, Jeff Settleman, Ari Firestone, David Stokoe
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): B121.
https://doi.org/10.1158/1535-7163.TARG-19-B121
Published: 01 December 2019
View article titled, Abstract B121: An oncogene-linked prodrug strategy in lung cancer
Journal Articles

Ras–MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer Cells

Ho-June Lee, Yi Cao, Victoria Pham, Elizabeth Blackwood, Catherine Wilson, Marie Evangelista, Christiaan Klijn, David Stokoe, Jeff Settleman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (4): 694–704.
https://doi.org/10.1158/1535-7163.MCT-16-0504
Published: 02 April 2017
View article titled, Ras–MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer Cells
Open the PDF for Ras–MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Abstract B90: Understanding the effects of RAF inhibitors on RAF signaling in B‐RAF V600E mutant versus wild type tumors

Ivana Yen, Kyung Song, David Stokoe, Barbara Brandhuber, Susan Gloor, Ignacio Aliagas, Daniel Anderson, Tony Morales, Guy Vigers, Mary Ludlam, Ryan Alvarado, Bonnie Liu, Steve Sideris, Sreema Ramaswamy, Christopher Heise, Marcia Belvin, Lori Friedman, Georgia Hatzivassiliou, Shiva Malek
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): B90.
https://doi.org/10.1158/1535-7163.TARG-09-B90
Published: 10 December 2009
View article titled, Abstract B90: Understanding the effects of RAF inhibitors on RAF signaling in B‐RAF V600E mutant versus wild type tumors
Journal Articles

Characterization of structurally distinct, isoform-selective phosphoinositide 3′-kinase inhibitors in combination with radiation in the treatment of glioblastoma

Jack S. Chen, Linda J. Zhou, Michal Entin-Meer, Xiaodong Yang, Mila Donker, Zachary A. Knight, William Weiss, Kevan M. Shokat, Daphne Haas-Kogan, David Stokoe
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (4): 841–850.
https://doi.org/10.1158/1535-7163.MCT-07-0393
Published: 15 April 2008
View article titled, Characterization of structurally distinct, isoform-selective phosphoinositide 3′-kinase inhibitors in combination with radiation in the treatment of glioblastoma
Open the PDF for Characterization of structurally distinct, isoform-selective phosphoinositide 3′-kinase inhibitors in combination with radiation in the treatment of glioblastoma in another window
Journal Articles

Dominant p110α activation in endometrial cancer.

Katsutoshi Oda, Jennifer Okada, David Stokoe, Yuji Taketani, Hiroyuki Kuramoto, Zachary Knight, Kevan Shokat, Frank McCormick
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): A251.
Published: 01 November 2007
View article titled, Dominant p110α activation in endometrial cancer.