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Daruka Mahadevan
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Journal Articles

Polyploidy in Cancer: Causal Mechanisms, Cancer-Specific Consequences, and Emerging Treatments

Patrick J. Conway, Jonathan Dao, Dmytro Kovalskyy, Daruka Mahadevan, Eloise Dray
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2024) 23 (5): 638–647.
https://doi.org/10.1158/1535-7163.MCT-23-0578
Published: 02 May 2024
View article titled, Polyploidy in Cancer: Causal Mechanisms, Cancer-Specific Consequences, and Emerging Treatments
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Journal Articles

Disruption of Aneuploidy and Senescence Induced by Aurora Inhibition Promotes Intrinsic Apoptosis in Double Hit or Double Expressor Diffuse Large B-cell Lymphomas

Shariful Islam, Wenqing Qi, Carla Morales, Laurence Cooke, Catherine Spier, Eric Weterings, Daruka Mahadevan
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (10): 2083–2093.
https://doi.org/10.1158/1535-7163.MCT-17-0089
Published: 02 October 2017
View article titled, Disruption of Aneuploidy and Senescence Induced by Aurora Inhibition Promotes Intrinsic Apoptosis in Double Hit or Double Expressor Diffuse Large B-cell Lymphomas
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Journal Articles

AT7519, a Cyclin-Dependent Kinase Inhibitor, Exerts Its Effects by Transcriptional Inhibition in Leukemia Cell Lines and Patient Samples

Matthew S. Squires, Laurence Cooke, Victoria Lock, Wenqing Qi, E. Jonathan Lewis, Neil T. Thompson, John F. Lyons, Daruka Mahadevan
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (4): 920–928.
https://doi.org/10.1158/1535-7163.MCT-09-1071
Published: 07 April 2010
View article titled, AT7519, a Cyclin-Dependent Kinase Inhibitor, Exerts Its Effects by Transcriptional Inhibition in Leukemia Cell Lines and Patient Samples
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Journal Articles

Discovery of a novel class of AKT pleckstrin homology domain inhibitors

Daruka Mahadevan, Garth Powis, Eugene A. Mash, Benjamin George, Vijay M. Gokhale, Shuxing Zhang, Kishore Shakalya, Lei Du-Cuny, Margareta Berggren, M. Ahad Ali, Umasish Jana, Nathan Ihle, Sylvestor Moses, Chloe Franklin, Satya Narayan, Nikhil Shirahatti, Emmanuelle J. Meuillet
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (9): 2621–2632.
https://doi.org/10.1158/1535-7163.MCT-07-2276
Published: 11 September 2008
View article titled, Discovery of a novel class of AKT pleckstrin homology domain inhibitors
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Journal Articles

Tumor-stroma interactions in pancreatic ductal adenocarcinoma

Daruka Mahadevan, Daniel D. Von Hoff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (4): 1186–1197.
https://doi.org/10.1158/1535-7163.MCT-06-0686
Published: 12 April 2007
View article titled, Tumor-stroma interactions in pancreatic ductal adenocarcinoma
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Journal Articles

Transcript profiling in peripheral T-cell lymphoma, not otherwise specified, and diffuse large B-cell lymphoma identifies distinct tumor profile signatures

Daruka Mahadevan, Catherine Spier, Kimiko Della Croce, Susan Miller, Benjamin George, Chris Riley, Stephen Warner, Thomas M. Grogan, Thomas P. Miller
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2005) 4 (12): 1867–1879.
https://doi.org/10.1158/1535-7163.MCT-05-0146
Published: 22 December 2005
View article titled, Transcript profiling in peripheral T-cell lymphoma, not otherwise specified, and diffuse large B-cell lymphoma identifies distinct tumor profile signatures
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Journal Articles

Specific Inhibition of the Akt1 Pleckstrin Homology Domain by D-3-Deoxy-Phosphatidyl-myo-Inositol Analogues

Emmanuelle J. Meuillet, Daruka Mahadevan, Hariprasad Vankayalapati, Margareta Berggren, Ryan Williams, Amy Coon, Alan P. Kozikowski, Garth Powis
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2003) 2 (4): 389–399.
Published: 01 April 2003
View article titled, Specific Inhibition of the Akt1 Pleckstrin Homology Domain by D-3-Deoxy-Phosphatidyl-<em>myo</em>-Inositol Analogues
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Journal Articles

Targeting Aurora2 Kinase in Oncogenesis: A Structural Bioinformatics Approach to Target Validation and Rational Drug Design

Hariprasad Vankayalapati, David J. Bearss, José W. Saldanha, Rubén M. Muñoz, Sangeeta Rojanala, Daniel D. Von Hoff, Daruka Mahadevan
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2003) 2 (3): 283–294.
Published: 01 March 2003
View article titled, Targeting Aurora2 Kinase in Oncogenesis: A Structural Bioinformatics Approach to Target Validation and Rational Drug Design
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