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Darren C. Phillips
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Journal Articles

Expanding the Repertoire for “Large Small Molecules”: Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers

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Ahmed Hamed Salem, Zhi-Fu Tao, Orlando F. Bueno, Jie Chen, Shuang Chen, Rohinton Edalji, Steven W. Elmore, Keith M. Fournier, Kaid C. Harper, Richard Hong, Gary J. Jenkins, Jianguo Ji, Russell A. Judge, John C. Kalvass, Russell C. Klix, Yi-Yin Ku, Joel D. Leverson, Richard A. Marks, Kennan C. Marsh, Rajeev M. Menon, Chang H. Park, Darren C. Phillips, Yu-Ming Pu, Saul H. Rosenberg, Yeshwant D. Sanzgiri, Ahmad Y. Sheikh, Yi Shi, Deanne Stolarik, Ahmed A. Suleiman, Xilu Wang, Geoff G.Z. Zhang, Nathaniel D. Catron, Andrew J. Souers
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (6): 999–1008.
https://doi.org/10.1158/1535-7163.MCT-21-0077
Published: 01 June 2021
View articletitled, Expanding the Repertoire for “Large Small Molecules”: Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers
Open the PDF for Expanding the Repertoire for “Large Small Molecules”: Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers in another window
Includes: Supplementary data
Journal Articles

Abstract A020: 5-Azacytidine primes AML cells for venetoclax-induced apoptosis by upregulating NOXA and PUMA protein expression

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Sha Jin, Julie Purkal, Relja Popovic, Yu Xiao, Larry Solomon, Erwin Boghaert, Joel Leverson, Darren C. Phillips
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): A020.
https://doi.org/10.1158/1535-7163.TARG-17-A020
Published: 01 January 2018
View articletitled, Abstract A020: 5-Azacytidine primes AML cells for venetoclax-induced apoptosis by upregulating NOXA and PUMA protein expression
Journal Articles

Abstract B58: BIM, a key player in apoptosis induction and acquired venetoclax resistance in follicular lymphoma cells

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Juraj Bodo, Xiaoxian Zhao, Andrew J. Souers, Darren C. Phillips, Mitchell R. Smith, Eric D. Hsi
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): B58.
https://doi.org/10.1158/1535-7163.TARG-15-B58
Published: 01 December 2015
View articletitled, Abstract B58: BIM, a key player in apoptosis induction and acquired venetoclax resistance in follicular lymphoma cells
Journal Articles

MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor

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Yu Xiao, Paul Nimmer, George S. Sheppard, Milan Bruncko, Paul Hessler, Xin Lu, Lisa Roberts-Rapp, William N. Pappano, Steven W. Elmore, Andrew J. Souers, Joel D. Leverson, Darren C. Phillips
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (8): 1837–1847.
https://doi.org/10.1158/1535-7163.MCT-14-0928
Published: 05 August 2015
View articletitled, MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor
Open the PDF for MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor in another window
Includes: Supplementary data