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Daniel L. Flynn
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Journal Articles

Abstract C074: VPS34 inhibition delays activation-induced STING degradation to prolong STING signaling and improve anti-tumor efficacy in preclinical models

Free
Madhumita Bogdan, Jodi Simeon, Mary J Timson, Hikmat Al-Hashimi, Bryan D Smith, Daniel L Flynn
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): C074.
https://doi.org/10.1158/1535-7163.TARG-23-C074
Published: 01 December 2023
View article titled, Abstract C074: VPS34 inhibition delays activation-induced STING degradation to prolong STING signaling and improve anti-tumor efficacy in preclinical models
Journal Articles

Abstract P084: DCC-3116, a first-in-class selective inhibitor of ULK1/2 kinases and autophagy, synergizes with EGFR inhibitors osimertinib and afatinib in NSCLC preclinical models

Free
Madhumita Bogdan, Mary J. Timson, Hikmat Al-Hashimi, Yu Zhan, Bryan D. Smith, Daniel L. Flynn
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P084.
https://doi.org/10.1158/1535-7163.TARG-21-P084
Published: 01 December 2021
View article titled, Abstract P084: DCC-3116, a first-in-class selective inhibitor of ULK1/2 kinases and autophagy, synergizes with EGFR inhibitors osimertinib and afatinib in NSCLC preclinical models
Journal Articles

Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages

Open Access
Bryan D. Smith, Michael D. Kaufman, Scott C. Wise, Yu Mi Ahn, Timothy M. Caldwell, Cynthia B. Leary, Wei-Ping Lu, Gege Tan, Lakshminarayana Vogeti, Subha Vogeti, Breelyn A. Wilky, Lara E. Davis, Maitreyi Sharma, Rodrigo Ruiz-Soto, Daniel L. Flynn
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (11): 2098–2109.
https://doi.org/10.1158/1535-7163.MCT-21-0361
Published: 01 November 2021
View article titled, Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages
Includes: Supplementary data
Journal Articles

Ripretinib and MEK Inhibitors Synergize to Induce Apoptosis in Preclinical Models of GIST and Systemic Mastocytosis

Free
Anu Gupta, Jarnail Singh, Alfonso García-Valverde, César Serrano, Daniel L. Flynn, Bryan D. Smith
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2021) 20 (7): 1234–1245.
https://doi.org/10.1158/1535-7163.MCT-20-0824
Published: 01 July 2021
View article titled, Ripretinib and MEK Inhibitors Synergize to Induce Apoptosis in Preclinical Models of GIST and Systemic Mastocytosis
Open the PDF for Ripretinib and MEK Inhibitors Synergize to Induce Apoptosis in Preclinical Models of GIST and Systemic Mastocytosis in another window
Journal Articles

A Phase I Study of LY3009120, a Pan-RAF Inhibitor, in Patients with Advanced or Metastatic Cancer

Available to Purchase
Ryan J. Sullivan, Antoine Hollebecque, Keith T. Flaherty, Geoffrey I. Shapiro, Jordi Rodon Ahnert, Michael J. Millward, Wei Zhang, Ling Gao, Amanda Sykes, Melinda D. Willard, Danni Yu, Andrew E. Schade, KrisAnne Crowe, Daniel L. Flynn, Michael D. Kaufman, James R. Henry, Sheng-Bin Peng, Karim A. Benhadji, Ilaria Conti, Michael S. Gordon, Ramon V. Tiu, David S. Hong
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2020) 19 (2): 460–467.
https://doi.org/10.1158/1535-7163.MCT-19-0681
Published: 06 February 2020
View article titled, A Phase I Study of LY3009120, a Pan-RAF Inhibitor, in Patients with Advanced or Metastatic Cancer
Open the PDF for A Phase I Study of LY3009120, a Pan-RAF Inhibitor, in Patients with Advanced or Metastatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract B129: Preclinical studies with DCC-3116, an ULK kinase inhibitor designed to inhibit autophagy as a potential strategy to address mutant RAS cancers

Free
Bryan D Smith, Lakshminarayana Vogeti, Anu Gupta, Jarnail Singh, Gada Al-Ani, Stacie L Bulfer, Timothy M Caldwell, Mary J Timson, Subha Vogeti, Yu Mi Ahn, Hikmat Al-Hashimi, Chase K Crawley, Cale L Heiniger, Cynthia B Leary, Justin T Proto, Quanrong Shen, Hanumaiah Telikepalli, Karen Yates, Wei-Ping Lu, Daniel L Flynn
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): B129.
https://doi.org/10.1158/1535-7163.TARG-19-B129
Published: 01 December 2019
View article titled, Abstract B129: Preclinical studies with DCC-3116, an ULK kinase inhibitor designed to inhibit autophagy as a potential strategy to address mutant RAS cancers
Journal Articles

The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors

Free
Allison S. Harney, George S. Karagiannis, Jeanine Pignatelli, Bryan D. Smith, Ece Kadioglu, Scott C. Wise, Molly M. Hood, Michael D. Kaufman, Cynthia B. Leary, Wei-Ping Lu, Gada Al-Ani, Xiaoming Chen, David Entenberg, Maja H. Oktay, Yarong Wang, Lawrence Chun, Michele De Palma, Joan G. Jones, Daniel L. Flynn, John S. Condeelis
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2017) 16 (11): 2486–2501.
https://doi.org/10.1158/1535-7163.MCT-17-0241
Published: 01 November 2017
View article titled, The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors
Open the PDF for The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors in another window
Includes: Supplementary data
Journal Articles

Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2

Free
Bryan D. Smith, Michael D. Kaufman, Cynthia B. Leary, Benjamin A. Turner, Scott C. Wise, Yu Mi Ahn, R. John Booth, Timothy M. Caldwell, Carol L. Ensinger, Molly M. Hood, Wei-Ping Lu, Tristan W. Patt, William C. Patt, Thomas J. Rutkoski, Thiwanka Samarakoon, Hanumaiah Telikepalli, Lakshminarayana Vogeti, Subha Vogeti, Karen M. Yates, Lawrence Chun, Lance J. Stewart, Michael Clare, Daniel L. Flynn
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (9): 2023–2034.
https://doi.org/10.1158/1535-7163.MCT-14-1105
Published: 02 September 2015
View article titled, Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2
Open the PDF for Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2 in another window
Includes: Supplementary data